Development and Characterization of Polyester and Acrylate-Based Composites with Hydroxyapatite and Halloysite Nanotubes for Medical Applications
We aimed to study the distribution of hydroxyapatite (HA) and halloysite nanotubes (HNTs) as fillers and their influence on the hydrophobic character of conventional polymers used in the biomedical field. The hydrophobic polyester poly (ε-caprolactone) (PCL) was blended with its more hydrophilic cou...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/12/8/1703 |
| _version_ | 1797560925049323520 |
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| author | Elena Torres Ivan Dominguez-Candela Sergio Castello-Palacios Anna Vallés-Lluch Vicent Fombuena |
| author_facet | Elena Torres Ivan Dominguez-Candela Sergio Castello-Palacios Anna Vallés-Lluch Vicent Fombuena |
| author_sort | Elena Torres |
| collection | DOAJ |
| description | We aimed to study the distribution of hydroxyapatite (HA) and halloysite nanotubes (HNTs) as fillers and their influence on the hydrophobic character of conventional polymers used in the biomedical field. The hydrophobic polyester poly (ε-caprolactone) (PCL) was blended with its more hydrophilic counterpart poly (lactic acid) (PLA) and the hydrophilic acrylate poly (2-hydroxyethyl methacrylate) (PHEMA) was analogously compared to poly (ethyl methacrylate) (PEMA) and its copolymer. The addition of HA and HNTs clearly improve surface wettability in neat samples (PCL and PHEMA), but not that of the corresponding binary blends. Energy-dispersive X-ray spectroscopy mapping analyses show a homogenous distribution of HA with appropriate Ca/P ratios between 1.3 and 2, even on samples that were incubated for seven days in simulated body fluid, with the exception of PHEMA, which is excessively hydrophilic to promote the deposition of salts on its surface. HNTs promote large aggregates on more hydrophilic polymers. The degradation process of the biodegradable polyester PCL blended with PLA, and the addition of HA and HNTs, provide hydrophilic units and decrease the overall crystallinity of PCL. Consequently, after 12 weeks of incubation in phosphate buffered saline the mass loss increases up to 48% and mechanical properties decrease above 60% compared with the PCL/PLA blend. |
| first_indexed | 2024-03-10T18:07:00Z |
| format | Article |
| id | doaj.art-77661258afaf43899d29a86c9482ba01 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T18:07:00Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-77661258afaf43899d29a86c9482ba012023-11-20T08:25:21ZengMDPI AGPolymers2073-43602020-07-01128170310.3390/polym12081703Development and Characterization of Polyester and Acrylate-Based Composites with Hydroxyapatite and Halloysite Nanotubes for Medical ApplicationsElena Torres0Ivan Dominguez-Candela1Sergio Castello-Palacios2Anna Vallés-Lluch3Vicent Fombuena4Textile Industry Research Association (AITEX), Plaza Emilio Sala 1, 03801 Alcoy, SpainTechnological Institute of Materials (ITM), Universitat Politècnica de València (UPV), Plaza Ferrándiz y Carbonell 1, 03801 Alcoy, SpainCentre for Biomaterials and Tissue Engineering, Universitat Politècnica de València (UPV), Camí de Vera s/n, 46022 Valencia, SpainCentre for Biomaterials and Tissue Engineering, Universitat Politècnica de València (UPV), Camí de Vera s/n, 46022 Valencia, SpainTechnological Institute of Materials (ITM), Universitat Politècnica de València (UPV), Plaza Ferrándiz y Carbonell 1, 03801 Alcoy, SpainWe aimed to study the distribution of hydroxyapatite (HA) and halloysite nanotubes (HNTs) as fillers and their influence on the hydrophobic character of conventional polymers used in the biomedical field. The hydrophobic polyester poly (ε-caprolactone) (PCL) was blended with its more hydrophilic counterpart poly (lactic acid) (PLA) and the hydrophilic acrylate poly (2-hydroxyethyl methacrylate) (PHEMA) was analogously compared to poly (ethyl methacrylate) (PEMA) and its copolymer. The addition of HA and HNTs clearly improve surface wettability in neat samples (PCL and PHEMA), but not that of the corresponding binary blends. Energy-dispersive X-ray spectroscopy mapping analyses show a homogenous distribution of HA with appropriate Ca/P ratios between 1.3 and 2, even on samples that were incubated for seven days in simulated body fluid, with the exception of PHEMA, which is excessively hydrophilic to promote the deposition of salts on its surface. HNTs promote large aggregates on more hydrophilic polymers. The degradation process of the biodegradable polyester PCL blended with PLA, and the addition of HA and HNTs, provide hydrophilic units and decrease the overall crystallinity of PCL. Consequently, after 12 weeks of incubation in phosphate buffered saline the mass loss increases up to 48% and mechanical properties decrease above 60% compared with the PCL/PLA blend.https://www.mdpi.com/2073-4360/12/8/1703biomedical polymershydroxyapatitehalloysitemechanical properties |
| spellingShingle | Elena Torres Ivan Dominguez-Candela Sergio Castello-Palacios Anna Vallés-Lluch Vicent Fombuena Development and Characterization of Polyester and Acrylate-Based Composites with Hydroxyapatite and Halloysite Nanotubes for Medical Applications Polymers biomedical polymers hydroxyapatite halloysite mechanical properties |
| title | Development and Characterization of Polyester and Acrylate-Based Composites with Hydroxyapatite and Halloysite Nanotubes for Medical Applications |
| title_full | Development and Characterization of Polyester and Acrylate-Based Composites with Hydroxyapatite and Halloysite Nanotubes for Medical Applications |
| title_fullStr | Development and Characterization of Polyester and Acrylate-Based Composites with Hydroxyapatite and Halloysite Nanotubes for Medical Applications |
| title_full_unstemmed | Development and Characterization of Polyester and Acrylate-Based Composites with Hydroxyapatite and Halloysite Nanotubes for Medical Applications |
| title_short | Development and Characterization of Polyester and Acrylate-Based Composites with Hydroxyapatite and Halloysite Nanotubes for Medical Applications |
| title_sort | development and characterization of polyester and acrylate based composites with hydroxyapatite and halloysite nanotubes for medical applications |
| topic | biomedical polymers hydroxyapatite halloysite mechanical properties |
| url | https://www.mdpi.com/2073-4360/12/8/1703 |
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