High Density Lipoproteins and Diabetes
Epidemiological studies have established that a high plasma high density lipoprotein cholesterol (HDL-C) level is associated with reduced cardiovascular risk. However, recent randomised clinical trials of interventions that increase HDL-C levels have failed to establish a causal basis for this relat...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/4/850 |
| _version_ | 1797538331098087424 |
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| author | Blake J. Cochran Kwok-Leung Ong Bikash Manandhar Kerry-Anne Rye |
| author_facet | Blake J. Cochran Kwok-Leung Ong Bikash Manandhar Kerry-Anne Rye |
| author_sort | Blake J. Cochran |
| collection | DOAJ |
| description | Epidemiological studies have established that a high plasma high density lipoprotein cholesterol (HDL-C) level is associated with reduced cardiovascular risk. However, recent randomised clinical trials of interventions that increase HDL-C levels have failed to establish a causal basis for this relationship. This has led to a shift in HDL research efforts towards developing strategies that improve the cardioprotective functions of HDLs, rather than simply increasing HDL-C levels. These efforts are also leading to the discovery of novel HDL functions that are unrelated to cardiovascular disease. One of the most recently identified functions of HDLs is their potent antidiabetic properties. The antidiabetic functions of HDLs, and recent key advances in this area are the subject of this review. Given that all forms of diabetes are increasing at an alarming rate globally, there is a clear unmet need to identify and develop new approaches that will complement existing therapies and reduce disease progression as well as reverse established disease. Exploration of a potential role for HDLs and their constituent lipids and apolipoproteins in this area is clearly warranted. This review highlights focus areas that have yet to be investigated and potential strategies for exploiting the antidiabetic functions of HDLs. |
| first_indexed | 2024-03-10T12:29:02Z |
| format | Article |
| id | doaj.art-776a5c09716849fabb48216eb743e118 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T12:29:02Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-776a5c09716849fabb48216eb743e1182023-11-21T14:47:25ZengMDPI AGCells2073-44092021-04-0110485010.3390/cells10040850High Density Lipoproteins and DiabetesBlake J. Cochran0Kwok-Leung Ong1Bikash Manandhar2Kerry-Anne Rye3Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Sydney, Sydney, NSW 2052, AustraliaLipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Sydney, Sydney, NSW 2052, AustraliaLipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Sydney, Sydney, NSW 2052, AustraliaLipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Sydney, Sydney, NSW 2052, AustraliaEpidemiological studies have established that a high plasma high density lipoprotein cholesterol (HDL-C) level is associated with reduced cardiovascular risk. However, recent randomised clinical trials of interventions that increase HDL-C levels have failed to establish a causal basis for this relationship. This has led to a shift in HDL research efforts towards developing strategies that improve the cardioprotective functions of HDLs, rather than simply increasing HDL-C levels. These efforts are also leading to the discovery of novel HDL functions that are unrelated to cardiovascular disease. One of the most recently identified functions of HDLs is their potent antidiabetic properties. The antidiabetic functions of HDLs, and recent key advances in this area are the subject of this review. Given that all forms of diabetes are increasing at an alarming rate globally, there is a clear unmet need to identify and develop new approaches that will complement existing therapies and reduce disease progression as well as reverse established disease. Exploration of a potential role for HDLs and their constituent lipids and apolipoproteins in this area is clearly warranted. This review highlights focus areas that have yet to be investigated and potential strategies for exploiting the antidiabetic functions of HDLs.https://www.mdpi.com/2073-4409/10/4/850HDLapoA-Idiabetesβ-cellsskeletal muscle |
| spellingShingle | Blake J. Cochran Kwok-Leung Ong Bikash Manandhar Kerry-Anne Rye High Density Lipoproteins and Diabetes Cells HDL apoA-I diabetes β-cells skeletal muscle |
| title | High Density Lipoproteins and Diabetes |
| title_full | High Density Lipoproteins and Diabetes |
| title_fullStr | High Density Lipoproteins and Diabetes |
| title_full_unstemmed | High Density Lipoproteins and Diabetes |
| title_short | High Density Lipoproteins and Diabetes |
| title_sort | high density lipoproteins and diabetes |
| topic | HDL apoA-I diabetes β-cells skeletal muscle |
| url | https://www.mdpi.com/2073-4409/10/4/850 |
| work_keys_str_mv | AT blakejcochran highdensitylipoproteinsanddiabetes AT kwokleungong highdensitylipoproteinsanddiabetes AT bikashmanandhar highdensitylipoproteinsanddiabetes AT kerryannerye highdensitylipoproteinsanddiabetes |