Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?
Abstract Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and multipotent differentiation. There is compelling evidence that the therapeutic effect of MSCs mainly depends on their...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2022-07-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-022-05034-x |
| _version_ | 1811224078495776768 |
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| author | Meng Kou Li Huang Jinjuan Yang Zhixin Chiang Shaoxiang Chen Jie Liu Liyan Guo Xiaoxian Zhang Xiaoya Zhou Xiang Xu Xiaomei Yan Yan Wang Jinqiu Zhang Aimin Xu Hung-fat Tse Qizhou Lian |
| author_facet | Meng Kou Li Huang Jinjuan Yang Zhixin Chiang Shaoxiang Chen Jie Liu Liyan Guo Xiaoxian Zhang Xiaoya Zhou Xiang Xu Xiaomei Yan Yan Wang Jinqiu Zhang Aimin Xu Hung-fat Tse Qizhou Lian |
| author_sort | Meng Kou |
| collection | DOAJ |
| description | Abstract Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and multipotent differentiation. There is compelling evidence that the therapeutic effect of MSCs mainly depends on their paracrine action. Extracellular vesicles (EVs) are fundamental paracrine effectors of MSCs and play a crucial role in intercellular communication, existing in various body fluids and cell supernatants. Since MSC-derived EVs retain the function of protocells and have lower immunogenicity, they have a wide range of prospective therapeutic applications with advantages over cell therapy. We describe some characteristics of MSC-EVs, and discuss their role in immune regulation and regeneration, with emphasis on the molecular mechanism and application of MSC-EVs in the treatment of fibrosis and support tissue repair. We also highlight current challenges in the clinical application of MSC-EVs and potential ways to overcome the problem of quality heterogeneity. |
| first_indexed | 2024-04-12T08:43:57Z |
| format | Article |
| id | doaj.art-776e7e18b2fe47399c776727f41e3f96 |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-04-12T08:43:57Z |
| publishDate | 2022-07-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-776e7e18b2fe47399c776727f41e3f962022-12-22T03:39:47ZengNature Publishing GroupCell Death and Disease2041-48892022-07-0113711610.1038/s41419-022-05034-xMesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?Meng Kou0Li Huang1Jinjuan Yang2Zhixin Chiang3Shaoxiang Chen4Jie Liu5Liyan Guo6Xiaoxian Zhang7Xiaoya Zhou8Xiang Xu9Xiaomei Yan10Yan Wang11Jinqiu Zhang12Aimin Xu13Hung-fat Tse14Qizhou Lian15Cord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical UniversityCord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical UniversityCord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical UniversityDepartment of Allied Health Sciences Faculty of Science, Tunku Abdul Rahman UniversityCord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical UniversityState Key Laboratory of Pharmaceutical Biotechnology, the University of Hong KongCord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical UniversityCord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical UniversityCord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical UniversityDepartment of Stem Cell & Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical UniversityDepartment of Chemical Biology, The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, Xiamen UniversityXiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen UniversityCord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical UniversityState Key Laboratory of Pharmaceutical Biotechnology, the University of Hong KongDepartment of Medicine, the University of Hong KongCord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical UniversityAbstract Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and multipotent differentiation. There is compelling evidence that the therapeutic effect of MSCs mainly depends on their paracrine action. Extracellular vesicles (EVs) are fundamental paracrine effectors of MSCs and play a crucial role in intercellular communication, existing in various body fluids and cell supernatants. Since MSC-derived EVs retain the function of protocells and have lower immunogenicity, they have a wide range of prospective therapeutic applications with advantages over cell therapy. We describe some characteristics of MSC-EVs, and discuss their role in immune regulation and regeneration, with emphasis on the molecular mechanism and application of MSC-EVs in the treatment of fibrosis and support tissue repair. We also highlight current challenges in the clinical application of MSC-EVs and potential ways to overcome the problem of quality heterogeneity.https://doi.org/10.1038/s41419-022-05034-x |
| spellingShingle | Meng Kou Li Huang Jinjuan Yang Zhixin Chiang Shaoxiang Chen Jie Liu Liyan Guo Xiaoxian Zhang Xiaoya Zhou Xiang Xu Xiaomei Yan Yan Wang Jinqiu Zhang Aimin Xu Hung-fat Tse Qizhou Lian Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool? Cell Death and Disease |
| title | Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool? |
| title_full | Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool? |
| title_fullStr | Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool? |
| title_full_unstemmed | Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool? |
| title_short | Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool? |
| title_sort | mesenchymal stem cell derived extracellular vesicles for immunomodulation and regeneration a next generation therapeutic tool |
| url | https://doi.org/10.1038/s41419-022-05034-x |
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