Immune Evasion of SARS-CoV-2 Omicron Subvariants
Since the SARS-CoV-2 Omicron variant (B.1.1.529) was declared a variant of concern (VOC) by the WHO on 24 November 2021, it has caused another global surge of cases. With extensive mutations in its spike glycoprotein, Omicron gained substantial capabilities to evade the antiviral immunity provided b...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/10/9/1545 |
| _version_ | 1797481557313716224 |
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| author | Hanzhong Ke Matthew R. Chang Wayne A. Marasco |
| author_facet | Hanzhong Ke Matthew R. Chang Wayne A. Marasco |
| author_sort | Hanzhong Ke |
| collection | DOAJ |
| description | Since the SARS-CoV-2 Omicron variant (B.1.1.529) was declared a variant of concern (VOC) by the WHO on 24 November 2021, it has caused another global surge of cases. With extensive mutations in its spike glycoprotein, Omicron gained substantial capabilities to evade the antiviral immunity provided by vaccination, hybrid immunity, or monoclonal antibodies. The Omicron subvariants BA.1, BA.2, BA.2.12.1, BA.4 and BA.5 extended this immune evasion capability by having additional unique mutations in their respective spike proteins. The ongoing Omicron wave and emergence of new Omicron subvariants leads to additional concerns regarding the efficacy of the current antiviral measurements. To have a better understanding of the Omicron subvariants, this review summarizes reports of the immune evasion of subvariants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5 as well as the molecular basis of immune evasion. |
| first_indexed | 2024-03-09T22:16:19Z |
| format | Article |
| id | doaj.art-776eeb3474cd44be9377d6dec27ca1d4 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T22:16:19Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-776eeb3474cd44be9377d6dec27ca1d42023-11-23T19:22:58ZengMDPI AGVaccines2076-393X2022-09-01109154510.3390/vaccines10091545Immune Evasion of SARS-CoV-2 Omicron SubvariantsHanzhong Ke0Matthew R. Chang1Wayne A. Marasco2Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USADepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USADepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USASince the SARS-CoV-2 Omicron variant (B.1.1.529) was declared a variant of concern (VOC) by the WHO on 24 November 2021, it has caused another global surge of cases. With extensive mutations in its spike glycoprotein, Omicron gained substantial capabilities to evade the antiviral immunity provided by vaccination, hybrid immunity, or monoclonal antibodies. The Omicron subvariants BA.1, BA.2, BA.2.12.1, BA.4 and BA.5 extended this immune evasion capability by having additional unique mutations in their respective spike proteins. The ongoing Omicron wave and emergence of new Omicron subvariants leads to additional concerns regarding the efficacy of the current antiviral measurements. To have a better understanding of the Omicron subvariants, this review summarizes reports of the immune evasion of subvariants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5 as well as the molecular basis of immune evasion.https://www.mdpi.com/2076-393X/10/9/1545SARS-CoV-2OmicronOmicron subvariantsimmune evasionspike mutationmolecular basis |
| spellingShingle | Hanzhong Ke Matthew R. Chang Wayne A. Marasco Immune Evasion of SARS-CoV-2 Omicron Subvariants Vaccines SARS-CoV-2 Omicron Omicron subvariants immune evasion spike mutation molecular basis |
| title | Immune Evasion of SARS-CoV-2 Omicron Subvariants |
| title_full | Immune Evasion of SARS-CoV-2 Omicron Subvariants |
| title_fullStr | Immune Evasion of SARS-CoV-2 Omicron Subvariants |
| title_full_unstemmed | Immune Evasion of SARS-CoV-2 Omicron Subvariants |
| title_short | Immune Evasion of SARS-CoV-2 Omicron Subvariants |
| title_sort | immune evasion of sars cov 2 omicron subvariants |
| topic | SARS-CoV-2 Omicron Omicron subvariants immune evasion spike mutation molecular basis |
| url | https://www.mdpi.com/2076-393X/10/9/1545 |
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