Primordial Drivers of Diabetes Heart Disease: Comprehensive Insights into Insulin Resistance
Insulin resistance has been regarded as a hallmark of diabetes heart disease (DHD). Numerous studies have shown that insulin resistance can affect blood circulation and myocardium, which indirectly cause cardiac hypertrophy and ventricular remodeling, participating in the pathogenesis of DHD. Meanwh...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Diabetes Association
2024-01-01
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| Series: | Diabetes & Metabolism Journal |
| Subjects: | |
| Online Access: | http://e-dmj.org/upload/pdf/dmj-2023-0110.pdf |
| _version_ | 1797321035899469824 |
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| author | Yajie Fan Zhipeng Yan Tingting Li Aolin Li Xinbiao Fan Zhongwen Qi Junping Zhang |
| author_facet | Yajie Fan Zhipeng Yan Tingting Li Aolin Li Xinbiao Fan Zhongwen Qi Junping Zhang |
| author_sort | Yajie Fan |
| collection | DOAJ |
| description | Insulin resistance has been regarded as a hallmark of diabetes heart disease (DHD). Numerous studies have shown that insulin resistance can affect blood circulation and myocardium, which indirectly cause cardiac hypertrophy and ventricular remodeling, participating in the pathogenesis of DHD. Meanwhile, hyperinsulinemia, hyperglycemia, and hyperlipidemia associated with insulin resistance can directly impair the metabolism and function of the heart. Targeting insulin resistance is a potential therapeutic strategy for the prevention of DHD. Currently, the role of insulin resistance in the pathogenic development of DHD is still under active research, as the pathological roles involved are complex and not yet fully understood, and the related therapeutic approaches are not well developed. In this review, we describe insulin resistance and add recent advances in the major pathological and physiological changes and underlying mechanisms by which insulin resistance leads to myocardial remodeling and dysfunction in the diabetic heart, including exosomal dysfunction, ferroptosis, and epigenetic factors. In addition, we discuss potential therapeutic approaches to improve insulin resistance and accelerate the development of cardiovascular protection drugs. |
| first_indexed | 2024-03-08T04:51:42Z |
| format | Article |
| id | doaj.art-776f38c7950b43459b5053e7cf01c834 |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-03-08T04:51:42Z |
| publishDate | 2024-01-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-776f38c7950b43459b5053e7cf01c8342024-02-08T04:09:37ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872024-01-01481193610.4093/dmj.2023.01102788Primordial Drivers of Diabetes Heart Disease: Comprehensive Insights into Insulin ResistanceYajie Fan0Zhipeng Yan1Tingting Li2Aolin Li3Xinbiao Fan4Zhongwen Qi5Junping Zhang6 Department of Cardiovascular, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China Department of Cardiovascular, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China Department of Cardiovascular, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China Department of Cardiovascular, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China Department of Cardiovascular, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China Institute of Gerontology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China Department of Cardiovascular, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaInsulin resistance has been regarded as a hallmark of diabetes heart disease (DHD). Numerous studies have shown that insulin resistance can affect blood circulation and myocardium, which indirectly cause cardiac hypertrophy and ventricular remodeling, participating in the pathogenesis of DHD. Meanwhile, hyperinsulinemia, hyperglycemia, and hyperlipidemia associated with insulin resistance can directly impair the metabolism and function of the heart. Targeting insulin resistance is a potential therapeutic strategy for the prevention of DHD. Currently, the role of insulin resistance in the pathogenic development of DHD is still under active research, as the pathological roles involved are complex and not yet fully understood, and the related therapeutic approaches are not well developed. In this review, we describe insulin resistance and add recent advances in the major pathological and physiological changes and underlying mechanisms by which insulin resistance leads to myocardial remodeling and dysfunction in the diabetic heart, including exosomal dysfunction, ferroptosis, and epigenetic factors. In addition, we discuss potential therapeutic approaches to improve insulin resistance and accelerate the development of cardiovascular protection drugs.http://e-dmj.org/upload/pdf/dmj-2023-0110.pdfautonomic nervous system diseasescell cycle checkpointsdiabetes mellitusdiabetic cardiomyopathiesenergy metabolismexosomesheart failureinsulin resistancemicrornas |
| spellingShingle | Yajie Fan Zhipeng Yan Tingting Li Aolin Li Xinbiao Fan Zhongwen Qi Junping Zhang Primordial Drivers of Diabetes Heart Disease: Comprehensive Insights into Insulin Resistance Diabetes & Metabolism Journal autonomic nervous system diseases cell cycle checkpoints diabetes mellitus diabetic cardiomyopathies energy metabolism exosomes heart failure insulin resistance micrornas |
| title | Primordial Drivers of Diabetes Heart Disease: Comprehensive Insights into Insulin Resistance |
| title_full | Primordial Drivers of Diabetes Heart Disease: Comprehensive Insights into Insulin Resistance |
| title_fullStr | Primordial Drivers of Diabetes Heart Disease: Comprehensive Insights into Insulin Resistance |
| title_full_unstemmed | Primordial Drivers of Diabetes Heart Disease: Comprehensive Insights into Insulin Resistance |
| title_short | Primordial Drivers of Diabetes Heart Disease: Comprehensive Insights into Insulin Resistance |
| title_sort | primordial drivers of diabetes heart disease comprehensive insights into insulin resistance |
| topic | autonomic nervous system diseases cell cycle checkpoints diabetes mellitus diabetic cardiomyopathies energy metabolism exosomes heart failure insulin resistance micrornas |
| url | http://e-dmj.org/upload/pdf/dmj-2023-0110.pdf |
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