COMPARATIVE ANTIHYPERLIPIDAEMIC EFFICACY OF TRACHYSPERMUM AMMI EXTRACTS IN ALBINO RABBITS
Comparative antihyperlipidaemic efficacy of Trachyspermum ammi (L) Sprague (Ajowain) extracts in chloroform, methanol, petroleum ether and water was investigated in albino rabbits. Hyperlipidaemia was induced with butter fed ad libitum and oral intubation of cholesterol 400 mg/kg body weight. Simvas...
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| Format: | Article |
| Language: | English |
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University of Agriculture, Faisalabad
2006-01-01
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| Series: | Pakistan Veterinary Journal |
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| Online Access: | http://pvj.com.pk/pdf-files/26_1/23-29.pdf |
| _version_ | 1830410789045927936 |
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| author | I. JAVED, Z. IQBAL, Z. U. RAHMAN, F. H. KHAN, F. MUHAMMAD, B. ASLAM AND L. ALI1 |
| author_facet | I. JAVED, Z. IQBAL, Z. U. RAHMAN, F. H. KHAN, F. MUHAMMAD, B. ASLAM AND L. ALI1 |
| author_sort | I. JAVED, Z. IQBAL, Z. U. RAHMAN, F. H. KHAN, F. MUHAMMAD, B. ASLAM AND L. ALI1 |
| collection | DOAJ |
| description | Comparative antihyperlipidaemic efficacy of Trachyspermum ammi (L) Sprague (Ajowain) extracts in chloroform, methanol, petroleum ether and water was investigated in albino rabbits. Hyperlipidaemia was induced with butter fed ad libitum and oral intubation of cholesterol 400 mg/kg body weight. Simvastatin was used as a synthetic cholesterol lowering drug. The results suggested that chloroform and water extracts of T. ammi seed had no hypolipidaemic activity. However, methanol and petroleum ether extracts equivalent to its 2 g/kg body weight powder and Simvastatin (0.6 mg/kg body weight) were equally effective in treating hyperlipidaemia in albino rabbits. Moreover, petroleum ether extract appeared to be more potent than methanol extract on the basis of increasing the level of HDL-cholesterol and lowering the LDL-cholesterol more effectively than methanol extract. Petroleum ether extract reduced atherogenic index (total cholesterol/HDL-cholesterol) more effectively than methanol extract. |
| first_indexed | 2024-12-20T19:36:20Z |
| format | Article |
| id | doaj.art-776fa96ed7884500a83407c9d3e2d13d |
| institution | Directory Open Access Journal |
| issn | 0253-8318 |
| language | English |
| last_indexed | 2024-12-20T19:36:20Z |
| publishDate | 2006-01-01 |
| publisher | University of Agriculture, Faisalabad |
| record_format | Article |
| series | Pakistan Veterinary Journal |
| spelling | doaj.art-776fa96ed7884500a83407c9d3e2d13d2022-12-21T19:28:38ZengUniversity of Agriculture, FaisalabadPakistan Veterinary Journal0253-83182006-01-012612329COMPARATIVE ANTIHYPERLIPIDAEMIC EFFICACY OF TRACHYSPERMUM AMMI EXTRACTS IN ALBINO RABBITSI. JAVED, Z. IQBAL, Z. U. RAHMAN, F. H. KHAN, F. MUHAMMAD, B. ASLAM AND L. ALI1Comparative antihyperlipidaemic efficacy of Trachyspermum ammi (L) Sprague (Ajowain) extracts in chloroform, methanol, petroleum ether and water was investigated in albino rabbits. Hyperlipidaemia was induced with butter fed ad libitum and oral intubation of cholesterol 400 mg/kg body weight. Simvastatin was used as a synthetic cholesterol lowering drug. The results suggested that chloroform and water extracts of T. ammi seed had no hypolipidaemic activity. However, methanol and petroleum ether extracts equivalent to its 2 g/kg body weight powder and Simvastatin (0.6 mg/kg body weight) were equally effective in treating hyperlipidaemia in albino rabbits. Moreover, petroleum ether extract appeared to be more potent than methanol extract on the basis of increasing the level of HDL-cholesterol and lowering the LDL-cholesterol more effectively than methanol extract. Petroleum ether extract reduced atherogenic index (total cholesterol/HDL-cholesterol) more effectively than methanol extract.http://pvj.com.pk/pdf-files/26_1/23-29.pdfLipid profileantihyperlipidaemiaTrachyspermum ammiSimvastatin |
| spellingShingle | I. JAVED, Z. IQBAL, Z. U. RAHMAN, F. H. KHAN, F. MUHAMMAD, B. ASLAM AND L. ALI1 COMPARATIVE ANTIHYPERLIPIDAEMIC EFFICACY OF TRACHYSPERMUM AMMI EXTRACTS IN ALBINO RABBITS Pakistan Veterinary Journal Lipid profile antihyperlipidaemia Trachyspermum ammi Simvastatin |
| title | COMPARATIVE ANTIHYPERLIPIDAEMIC EFFICACY OF TRACHYSPERMUM AMMI EXTRACTS IN ALBINO RABBITS |
| title_full | COMPARATIVE ANTIHYPERLIPIDAEMIC EFFICACY OF TRACHYSPERMUM AMMI EXTRACTS IN ALBINO RABBITS |
| title_fullStr | COMPARATIVE ANTIHYPERLIPIDAEMIC EFFICACY OF TRACHYSPERMUM AMMI EXTRACTS IN ALBINO RABBITS |
| title_full_unstemmed | COMPARATIVE ANTIHYPERLIPIDAEMIC EFFICACY OF TRACHYSPERMUM AMMI EXTRACTS IN ALBINO RABBITS |
| title_short | COMPARATIVE ANTIHYPERLIPIDAEMIC EFFICACY OF TRACHYSPERMUM AMMI EXTRACTS IN ALBINO RABBITS |
| title_sort | comparative antihyperlipidaemic efficacy of trachyspermum ammi extracts in albino rabbits |
| topic | Lipid profile antihyperlipidaemia Trachyspermum ammi Simvastatin |
| url | http://pvj.com.pk/pdf-files/26_1/23-29.pdf |
| work_keys_str_mv | AT ijavedziqbalzurahmanfhkhanfmuhammadbaslamandlali1 comparativeantihyperlipidaemicefficacyoftrachyspermumammiextractsinalbinorabbits |