The Role of Ceramides in Diabetes and Cardiovascular Disease Regulation of Ceramides by Adipokines
Metabolic dysfunction is intertwined with the pathophysiology of both diabetes and cardiovascular disease. Recently, one particular lipid class has been shown to influence the development and sustainment of these diseases: ceramides. As a subtype of sphingolipids, these species are particularly cent...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2020.569250/full |
| _version_ | 1828832617760292864 |
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| author | Bianca C. Field Ruth Gordillo Philipp E. Scherer Philipp E. Scherer |
| author_facet | Bianca C. Field Ruth Gordillo Philipp E. Scherer Philipp E. Scherer |
| author_sort | Bianca C. Field |
| collection | DOAJ |
| description | Metabolic dysfunction is intertwined with the pathophysiology of both diabetes and cardiovascular disease. Recently, one particular lipid class has been shown to influence the development and sustainment of these diseases: ceramides. As a subtype of sphingolipids, these species are particularly central to many sphingolipid pathways. Increased levels of ceramides are known to correlate with impaired cardiovascular and metabolic health. Furthermore, the interaction between ceramides and adipokines, most notably adiponectin and leptin, appears to play a role in the pathophysiology of these conditions. Adiponectin appears to counteract the detrimental effects of elevated ceramides, largely through activation of the ceramidase activity of its receptors. Elevated ceramides appear to worsen leptin resistance, which is an important phenomenon in the pathophysiology of obesity and metabolic syndrome. |
| first_indexed | 2024-12-12T16:57:31Z |
| format | Article |
| id | doaj.art-7772447eb63d4aab8afe4be39a8470db |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-12T16:57:31Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-7772447eb63d4aab8afe4be39a8470db2022-12-22T00:18:11ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-10-011110.3389/fendo.2020.569250569250The Role of Ceramides in Diabetes and Cardiovascular Disease Regulation of Ceramides by AdipokinesBianca C. Field0Ruth Gordillo1Philipp E. Scherer2Philipp E. Scherer3Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United StatesTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United StatesTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United StatesDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, United StatesMetabolic dysfunction is intertwined with the pathophysiology of both diabetes and cardiovascular disease. Recently, one particular lipid class has been shown to influence the development and sustainment of these diseases: ceramides. As a subtype of sphingolipids, these species are particularly central to many sphingolipid pathways. Increased levels of ceramides are known to correlate with impaired cardiovascular and metabolic health. Furthermore, the interaction between ceramides and adipokines, most notably adiponectin and leptin, appears to play a role in the pathophysiology of these conditions. Adiponectin appears to counteract the detrimental effects of elevated ceramides, largely through activation of the ceramidase activity of its receptors. Elevated ceramides appear to worsen leptin resistance, which is an important phenomenon in the pathophysiology of obesity and metabolic syndrome.https://www.frontiersin.org/article/10.3389/fendo.2020.569250/fullleptinadiponectinadiponectin receptorssphingolipidsceramidaseadipokine |
| spellingShingle | Bianca C. Field Ruth Gordillo Philipp E. Scherer Philipp E. Scherer The Role of Ceramides in Diabetes and Cardiovascular Disease Regulation of Ceramides by Adipokines Frontiers in Endocrinology leptin adiponectin adiponectin receptors sphingolipids ceramidase adipokine |
| title | The Role of Ceramides in Diabetes and Cardiovascular Disease Regulation of Ceramides by Adipokines |
| title_full | The Role of Ceramides in Diabetes and Cardiovascular Disease Regulation of Ceramides by Adipokines |
| title_fullStr | The Role of Ceramides in Diabetes and Cardiovascular Disease Regulation of Ceramides by Adipokines |
| title_full_unstemmed | The Role of Ceramides in Diabetes and Cardiovascular Disease Regulation of Ceramides by Adipokines |
| title_short | The Role of Ceramides in Diabetes and Cardiovascular Disease Regulation of Ceramides by Adipokines |
| title_sort | role of ceramides in diabetes and cardiovascular disease regulation of ceramides by adipokines |
| topic | leptin adiponectin adiponectin receptors sphingolipids ceramidase adipokine |
| url | https://www.frontiersin.org/article/10.3389/fendo.2020.569250/full |
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