The Developmental Transcriptome of Aedes albopictus, a Major Worldwide Human Disease Vector
Aedes albopictus mosquitoes are important vectors for a number of human pathogens including the Zika, dengue, and chikungunya viruses. Capable of displacing Aedes aegypti populations, this mosquito adapts to cooler environments which increases its geographical range and transmission potential. There...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Oxford University Press
2020-03-01
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| Series: | G3: Genes, Genomes, Genetics |
| Subjects: | |
| Online Access: | http://g3journal.org/lookup/doi/10.1534/g3.119.401006 |
| _version_ | 1819099979800641536 |
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| author | Stephanie Gamez Igor Antoshechkin Stelia C. Mendez-Sanchez Omar S. Akbari |
| author_facet | Stephanie Gamez Igor Antoshechkin Stelia C. Mendez-Sanchez Omar S. Akbari |
| author_sort | Stephanie Gamez |
| collection | DOAJ |
| description | Aedes albopictus mosquitoes are important vectors for a number of human pathogens including the Zika, dengue, and chikungunya viruses. Capable of displacing Aedes aegypti populations, this mosquito adapts to cooler environments which increases its geographical range and transmission potential. There are limited control strategies for Aedes albopictus mosquitoes which is likely attributed to the lack of comprehensive biological studies on this emerging vector. To fill this void, here using RNAseq we characterized Aedes albopictus mRNA expression profiles at 34 distinct time points throughout development providing the first high-resolution comprehensive view of the developmental transcriptome of this worldwide human disease vector. This enabled us to identify several patterns of shared gene expression among tissues as well as sex-specific expression patterns. To illuminate the similarities and differences with Aedes aegypti, a related human disease vector, we also performed a comparative analysis between the two developmental transcriptomes, identifying life stages where the two species exhibit similar and distinct gene expression patterns. These findings provide insights into the similarities and differences between Aedes albopictus and Aedes aegypti mosquito biology. In summary, the results generated from this study should form the basis for future investigations on the biology of Aedes albopictus and provide a gold mine resource for the development of transgene-based vector control strategies. |
| first_indexed | 2024-12-22T00:55:29Z |
| format | Article |
| id | doaj.art-77725008d2154b2388aef4aaa99be4e4 |
| institution | Directory Open Access Journal |
| issn | 2160-1836 |
| language | English |
| last_indexed | 2024-12-22T00:55:29Z |
| publishDate | 2020-03-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | G3: Genes, Genomes, Genetics |
| spelling | doaj.art-77725008d2154b2388aef4aaa99be4e42022-12-21T18:44:19ZengOxford University PressG3: Genes, Genomes, Genetics2160-18362020-03-011031051106210.1534/g3.119.40100618The Developmental Transcriptome of Aedes albopictus, a Major Worldwide Human Disease VectorStephanie GamezIgor AntoshechkinStelia C. Mendez-SanchezOmar S. AkbariAedes albopictus mosquitoes are important vectors for a number of human pathogens including the Zika, dengue, and chikungunya viruses. Capable of displacing Aedes aegypti populations, this mosquito adapts to cooler environments which increases its geographical range and transmission potential. There are limited control strategies for Aedes albopictus mosquitoes which is likely attributed to the lack of comprehensive biological studies on this emerging vector. To fill this void, here using RNAseq we characterized Aedes albopictus mRNA expression profiles at 34 distinct time points throughout development providing the first high-resolution comprehensive view of the developmental transcriptome of this worldwide human disease vector. This enabled us to identify several patterns of shared gene expression among tissues as well as sex-specific expression patterns. To illuminate the similarities and differences with Aedes aegypti, a related human disease vector, we also performed a comparative analysis between the two developmental transcriptomes, identifying life stages where the two species exhibit similar and distinct gene expression patterns. These findings provide insights into the similarities and differences between Aedes albopictus and Aedes aegypti mosquito biology. In summary, the results generated from this study should form the basis for future investigations on the biology of Aedes albopictus and provide a gold mine resource for the development of transgene-based vector control strategies.http://g3journal.org/lookup/doi/10.1534/g3.119.401006aedes albopictustranscriptomedevelopmentzikadengueaedes aegyptirna-seq |
| spellingShingle | Stephanie Gamez Igor Antoshechkin Stelia C. Mendez-Sanchez Omar S. Akbari The Developmental Transcriptome of Aedes albopictus, a Major Worldwide Human Disease Vector G3: Genes, Genomes, Genetics aedes albopictus transcriptome development zika dengue aedes aegypti rna-seq |
| title | The Developmental Transcriptome of Aedes albopictus, a Major Worldwide Human Disease Vector |
| title_full | The Developmental Transcriptome of Aedes albopictus, a Major Worldwide Human Disease Vector |
| title_fullStr | The Developmental Transcriptome of Aedes albopictus, a Major Worldwide Human Disease Vector |
| title_full_unstemmed | The Developmental Transcriptome of Aedes albopictus, a Major Worldwide Human Disease Vector |
| title_short | The Developmental Transcriptome of Aedes albopictus, a Major Worldwide Human Disease Vector |
| title_sort | developmental transcriptome of aedes albopictus a major worldwide human disease vector |
| topic | aedes albopictus transcriptome development zika dengue aedes aegypti rna-seq |
| url | http://g3journal.org/lookup/doi/10.1534/g3.119.401006 |
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