In-vitro antisickling and sickling-reversal activities of Carica papaya fruit at different stages of ripening
Objective: Sickle cell disease (SCD) is a haemoglobinopathy that causes several clinical complications. Unripe Carica papaya has been shown to possess antisickling activity that could reduce these complications. This study aimed to examine the presence of antisickling and sickling-reversal activitie...
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| Format: | Article |
| Language: | English |
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Babcock Medical Society
2020-12-01
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| Series: | Babcock University Medical Journal |
| Subjects: | |
| Online Access: | http://bumj.babcock.edu.ng/index.php/bumj/article/view/38 |
| _version_ | 1818776601956974592 |
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| author | Modupe Adetayo Oluwatosin Shokunbi Adesola Oyelese Adekunle Adetayo |
| author_facet | Modupe Adetayo Oluwatosin Shokunbi Adesola Oyelese Adekunle Adetayo |
| author_sort | Modupe Adetayo |
| collection | DOAJ |
| description | Objective: Sickle cell disease (SCD) is a haemoglobinopathy that causes several clinical complications. Unripe Carica papaya has been shown to possess antisickling activity that could reduce these complications. This study aimed to examine the presence of antisickling and sickling-reversal activities of aqueous extracts and ethyl acetate fractions of C. papaya fruit at different stages of ripening.
Methods: Unripe, partly ripe, and fully ripe fruits were quantitatively screened for some phytochemicals using standard methods. Blood samples from sickle cell patients were used to investigate antisickling and sickling reversal activities of aqueous extracts and ethyl acetate fractions of the fruits. Data were analysed using one-way ANOVA. The p-value was set at 0.05.
Results: Phytochemicals such as alkaloids, saponins, tannins, flavonoids and polyphenols were found in varying concentrations in C. papaya fruit at the different stages of ripening. All extracts and fractions showed antisickling and sickling-reversal activities with the ethyl acetate fraction of partly ripe C. papaya being most effective.Â
Conclusion: The study showed that C. papaya fruit at different stages of ripening contains antisickling and sickling-reversal activities which may help reduce the associated complications of SCD when consumed by affected individuals. |
| first_indexed | 2024-12-18T11:15:32Z |
| format | Article |
| id | doaj.art-777304b0796b45f69f41e632b52f8f2d |
| institution | Directory Open Access Journal |
| issn | 2465-6666 2756-4657 |
| language | English |
| last_indexed | 2024-12-18T11:15:32Z |
| publishDate | 2020-12-01 |
| publisher | Babcock Medical Society |
| record_format | Article |
| series | Babcock University Medical Journal |
| spelling | doaj.art-777304b0796b45f69f41e632b52f8f2d2022-12-21T21:09:56ZengBabcock Medical SocietyBabcock University Medical Journal2465-66662756-46572020-12-013210.38029/bumj.v3i2.3838In-vitro antisickling and sickling-reversal activities of Carica papaya fruit at different stages of ripeningModupe AdetayoOluwatosin ShokunbiAdesola OyeleseAdekunle Adetayo0NMA, MDCAN, NAOMSObjective: Sickle cell disease (SCD) is a haemoglobinopathy that causes several clinical complications. Unripe Carica papaya has been shown to possess antisickling activity that could reduce these complications. This study aimed to examine the presence of antisickling and sickling-reversal activities of aqueous extracts and ethyl acetate fractions of C. papaya fruit at different stages of ripening. Methods: Unripe, partly ripe, and fully ripe fruits were quantitatively screened for some phytochemicals using standard methods. Blood samples from sickle cell patients were used to investigate antisickling and sickling reversal activities of aqueous extracts and ethyl acetate fractions of the fruits. Data were analysed using one-way ANOVA. The p-value was set at 0.05. Results: Phytochemicals such as alkaloids, saponins, tannins, flavonoids and polyphenols were found in varying concentrations in C. papaya fruit at the different stages of ripening. All extracts and fractions showed antisickling and sickling-reversal activities with the ethyl acetate fraction of partly ripe C. papaya being most effective. Conclusion: The study showed that C. papaya fruit at different stages of ripening contains antisickling and sickling-reversal activities which may help reduce the associated complications of SCD when consumed by affected individuals.http://bumj.babcock.edu.ng/index.php/bumj/article/view/38AntisicklingSickling-ReversalAntioxidantCarica papaya |
| spellingShingle | Modupe Adetayo Oluwatosin Shokunbi Adesola Oyelese Adekunle Adetayo In-vitro antisickling and sickling-reversal activities of Carica papaya fruit at different stages of ripening Babcock University Medical Journal Antisickling Sickling-Reversal Antioxidant Carica papaya |
| title | In-vitro antisickling and sickling-reversal activities of Carica papaya fruit at different stages of ripening |
| title_full | In-vitro antisickling and sickling-reversal activities of Carica papaya fruit at different stages of ripening |
| title_fullStr | In-vitro antisickling and sickling-reversal activities of Carica papaya fruit at different stages of ripening |
| title_full_unstemmed | In-vitro antisickling and sickling-reversal activities of Carica papaya fruit at different stages of ripening |
| title_short | In-vitro antisickling and sickling-reversal activities of Carica papaya fruit at different stages of ripening |
| title_sort | in vitro antisickling and sickling reversal activities of carica papaya fruit at different stages of ripening |
| topic | Antisickling Sickling-Reversal Antioxidant Carica papaya |
| url | http://bumj.babcock.edu.ng/index.php/bumj/article/view/38 |
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