Natural products targeting Nrf2/ARE signaling pathway in the treatment of inflammatory bowel disease
Inflammatory bowel disease (IBD) is a special chronic intestinal inflammatory disease, which is mainly divided into Crohn's disease (CD) and ulcerative colitis (UC). Its occurrence is a complex process that regulated by multiple signaling pathways, including nuclear factor erythroid 2-related f...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223007400 |
| _version_ | 1797801847421927424 |
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| author | Botong Li Yixuan Wang Xiaolin Jiang Hongwei Du Yan Shi Minghui Xiu Yongqi Liu Jianzheng He |
| author_facet | Botong Li Yixuan Wang Xiaolin Jiang Hongwei Du Yan Shi Minghui Xiu Yongqi Liu Jianzheng He |
| author_sort | Botong Li |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a special chronic intestinal inflammatory disease, which is mainly divided into Crohn's disease (CD) and ulcerative colitis (UC). Its occurrence is a complex process that regulated by multiple signaling pathways, including nuclear factor erythroid 2-related factor (Nrf2)/ antioxidant response element (ARE) signaling pathway. Nrf2/ARE pathway as the central defense mechanism against oxidative stress controls the expression of many antioxidant and anti-inflammatory genes in the nucleus, and plays a crucial role in the treatment of IBD. Various studies have proved that many natural compounds target Nrf2/ARE signaling pathway to treat IBD. Here, we introduced the regulatory mechanism of the Nrf2/ARE pathway, and its role in IBD and IBD complications (intestinal fibrosis and colorectal cancer (CRC)); summarized the research progress of Nrf2 targeted natural compounds and extracts in the treatment of IBD; and finally described the intestinal microbiota that alleviate or treat IBD via activating Nrf2/ARE signaling pathway. This review highlights the potential for targeting Nrf2/ARE pathway to treat IBD. |
| first_indexed | 2024-03-13T04:56:46Z |
| format | Article |
| id | doaj.art-7774723a76664b058d96608cb7615bb9 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-13T04:56:46Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-7774723a76664b058d96608cb7615bb92023-06-18T05:00:48ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-08-01164114950Natural products targeting Nrf2/ARE signaling pathway in the treatment of inflammatory bowel diseaseBotong Li0Yixuan Wang1Xiaolin Jiang2Hongwei Du3Yan Shi4Minghui Xiu5Yongqi Liu6Jianzheng He7Provincial-level Key Laboratory for Molecular Medicine of Major Diseases and The Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and University, Gansu University of Chinese Medicine, Lanzhou 730000, China; College of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, ChinaCollege of Public Health, Gansu University of Chinese Medicine, Lanzhou 730000, China; Key Laboratory for Transfer of Dunhuang Medicine at the Provincial and Ministerial Level, Gansu University of Chinese Medicine, Lanzhou 730000, ChinaProvincial-level Key Laboratory for Molecular Medicine of Major Diseases and The Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and University, Gansu University of Chinese Medicine, Lanzhou 730000, China; College of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, ChinaGansu University of Political Science and Law, Lanzhou 730000, ChinaProvincial-level Key Laboratory for Molecular Medicine of Major Diseases and The Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and University, Gansu University of Chinese Medicine, Lanzhou 730000, China; College of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, ChinaCollege of Public Health, Gansu University of Chinese Medicine, Lanzhou 730000, China; Key Laboratory for Transfer of Dunhuang Medicine at the Provincial and Ministerial Level, Gansu University of Chinese Medicine, Lanzhou 730000, China; Corresponding author at: College of Public Health, Gansu University of Chinese Medicine, Lanzhou 730000, China.Provincial-level Key Laboratory for Molecular Medicine of Major Diseases and The Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and University, Gansu University of Chinese Medicine, Lanzhou 730000, China; Key Laboratory for Transfer of Dunhuang Medicine at the Provincial and Ministerial Level, Gansu University of Chinese Medicine, Lanzhou 730000, China; Corresponding authors at: Provincial-level Key Laboratory for Molecular Medicine of Major Diseases and The Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and University, Gansu University of Chinese Medicine, Lanzhou 730000, China.Provincial-level Key Laboratory for Molecular Medicine of Major Diseases and The Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and University, Gansu University of Chinese Medicine, Lanzhou 730000, China; College of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China; Key Laboratory for Transfer of Dunhuang Medicine at the Provincial and Ministerial Level, Gansu University of Chinese Medicine, Lanzhou 730000, China; Corresponding authors at: Provincial-level Key Laboratory for Molecular Medicine of Major Diseases and The Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and University, Gansu University of Chinese Medicine, Lanzhou 730000, China.Inflammatory bowel disease (IBD) is a special chronic intestinal inflammatory disease, which is mainly divided into Crohn's disease (CD) and ulcerative colitis (UC). Its occurrence is a complex process that regulated by multiple signaling pathways, including nuclear factor erythroid 2-related factor (Nrf2)/ antioxidant response element (ARE) signaling pathway. Nrf2/ARE pathway as the central defense mechanism against oxidative stress controls the expression of many antioxidant and anti-inflammatory genes in the nucleus, and plays a crucial role in the treatment of IBD. Various studies have proved that many natural compounds target Nrf2/ARE signaling pathway to treat IBD. Here, we introduced the regulatory mechanism of the Nrf2/ARE pathway, and its role in IBD and IBD complications (intestinal fibrosis and colorectal cancer (CRC)); summarized the research progress of Nrf2 targeted natural compounds and extracts in the treatment of IBD; and finally described the intestinal microbiota that alleviate or treat IBD via activating Nrf2/ARE signaling pathway. This review highlights the potential for targeting Nrf2/ARE pathway to treat IBD.http://www.sciencedirect.com/science/article/pii/S0753332223007400Nrf2/ARE signaling pathwayInflammatory bowel diseaseNature compoundsNatural extractCompound recipeGut microbe |
| spellingShingle | Botong Li Yixuan Wang Xiaolin Jiang Hongwei Du Yan Shi Minghui Xiu Yongqi Liu Jianzheng He Natural products targeting Nrf2/ARE signaling pathway in the treatment of inflammatory bowel disease Biomedicine & Pharmacotherapy Nrf2/ARE signaling pathway Inflammatory bowel disease Nature compounds Natural extract Compound recipe Gut microbe |
| title | Natural products targeting Nrf2/ARE signaling pathway in the treatment of inflammatory bowel disease |
| title_full | Natural products targeting Nrf2/ARE signaling pathway in the treatment of inflammatory bowel disease |
| title_fullStr | Natural products targeting Nrf2/ARE signaling pathway in the treatment of inflammatory bowel disease |
| title_full_unstemmed | Natural products targeting Nrf2/ARE signaling pathway in the treatment of inflammatory bowel disease |
| title_short | Natural products targeting Nrf2/ARE signaling pathway in the treatment of inflammatory bowel disease |
| title_sort | natural products targeting nrf2 are signaling pathway in the treatment of inflammatory bowel disease |
| topic | Nrf2/ARE signaling pathway Inflammatory bowel disease Nature compounds Natural extract Compound recipe Gut microbe |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223007400 |
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