Association between the Polymorphisms rs2070744, 4b/a and rs1799983 of the <i>NOS3</i> Gene with Chronic Kidney Disease of Uncertain or Non-Traditional Etiology in Mexican Patients
<i>Background and Objectives</i>: Chronic Kidney Disease of uncertain or non-traditional etiology (CKDnT) is a form of chronic kidney disease of undetermined etiology (CKDu) and is not associated with traditional risk factors. The aim of this study was to investigate the association of p...
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MDPI AG
2023-04-01
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| Online Access: | https://www.mdpi.com/1648-9144/59/5/829 |
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| author | Alejandro Marín-Medina José Juan Gómez-Ramos Norberto Mendoza-Morales Luis Eduardo Figuera-Villanueva |
| author_facet | Alejandro Marín-Medina José Juan Gómez-Ramos Norberto Mendoza-Morales Luis Eduardo Figuera-Villanueva |
| author_sort | Alejandro Marín-Medina |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Chronic Kidney Disease of uncertain or non-traditional etiology (CKDnT) is a form of chronic kidney disease of undetermined etiology (CKDu) and is not associated with traditional risk factors. The aim of this study was to investigate the association of polymorphisms rs2070744, 4b/a and rs1799983 of the <i>NOS3</i> gene with CKDnT in Mexican patients. <i>Materials and Methods</i>: We included 105 patients with CKDnT and 90 controls. Genotyping was performed by PCR-RFLP’s, genotypic and allelic frequencies were determined and compared between the two groups using <i>χ</i><sup>2</sup> analysis, and differences were expressed as odd ratios with 95% confidence intervals (CI). Values of <i>p</i> < 0.05 were considered statistically significant. <i>Results:</i> Overall, 80% of patients were male. The rs1799983 polymorphism in NOS3 was found to be associated with CKDnT in the Mexican population (<i>p</i> = 0.006) (OR = 0.397; 95% CI, 0.192–0.817) under a dominant model. The genotype frequency was significantly different between the CKDnT and control groups (<i>χ</i><sup>2</sup> = 8.298, <i>p</i> = 0.016). <i>Conclusions</i>: The results of this study indicate that there is an association between the rs2070744 polymorphism and CKDnT in the Mexican population. This polymorphism can play an important role in the pathophysiology of CKDnT whenever there is previous endothelial dysfunction. |
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| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T03:31:21Z |
| publishDate | 2023-04-01 |
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| series | Medicina |
| spelling | doaj.art-77754eafa4504be19b302e284d9b3ad32023-11-18T02:20:46ZengMDPI AGMedicina1010-660X1648-91442023-04-0159582910.3390/medicina59050829Association between the Polymorphisms rs2070744, 4b/a and rs1799983 of the <i>NOS3</i> Gene with Chronic Kidney Disease of Uncertain or Non-Traditional Etiology in Mexican PatientsAlejandro Marín-Medina0José Juan Gómez-Ramos1Norberto Mendoza-Morales2Luis Eduardo Figuera-Villanueva3Departamento de Biología Molecular y Genómicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44100, Jalisco, MexicoDepartamento de Urgencias, Hospital General de Zona No. 89, Instituto Mexicano del Seguro Social, Guadalajara 44100, Jalisco, MexicoDepartamento de Urgencias, Hospital General de Zona No. 89, Instituto Mexicano del Seguro Social, Guadalajara 44100, Jalisco, MexicoDepartamento de Biología Molecular y Genómicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44100, Jalisco, Mexico<i>Background and Objectives</i>: Chronic Kidney Disease of uncertain or non-traditional etiology (CKDnT) is a form of chronic kidney disease of undetermined etiology (CKDu) and is not associated with traditional risk factors. The aim of this study was to investigate the association of polymorphisms rs2070744, 4b/a and rs1799983 of the <i>NOS3</i> gene with CKDnT in Mexican patients. <i>Materials and Methods</i>: We included 105 patients with CKDnT and 90 controls. Genotyping was performed by PCR-RFLP’s, genotypic and allelic frequencies were determined and compared between the two groups using <i>χ</i><sup>2</sup> analysis, and differences were expressed as odd ratios with 95% confidence intervals (CI). Values of <i>p</i> < 0.05 were considered statistically significant. <i>Results:</i> Overall, 80% of patients were male. The rs1799983 polymorphism in NOS3 was found to be associated with CKDnT in the Mexican population (<i>p</i> = 0.006) (OR = 0.397; 95% CI, 0.192–0.817) under a dominant model. The genotype frequency was significantly different between the CKDnT and control groups (<i>χ</i><sup>2</sup> = 8.298, <i>p</i> = 0.016). <i>Conclusions</i>: The results of this study indicate that there is an association between the rs2070744 polymorphism and CKDnT in the Mexican population. This polymorphism can play an important role in the pathophysiology of CKDnT whenever there is previous endothelial dysfunction.https://www.mdpi.com/1648-9144/59/5/829renal insufficiencychronicpolymorphismgeneticnitric oxide synthase type III |
| spellingShingle | Alejandro Marín-Medina José Juan Gómez-Ramos Norberto Mendoza-Morales Luis Eduardo Figuera-Villanueva Association between the Polymorphisms rs2070744, 4b/a and rs1799983 of the <i>NOS3</i> Gene with Chronic Kidney Disease of Uncertain or Non-Traditional Etiology in Mexican Patients Medicina renal insufficiency chronic polymorphism genetic nitric oxide synthase type III |
| title | Association between the Polymorphisms rs2070744, 4b/a and rs1799983 of the <i>NOS3</i> Gene with Chronic Kidney Disease of Uncertain or Non-Traditional Etiology in Mexican Patients |
| title_full | Association between the Polymorphisms rs2070744, 4b/a and rs1799983 of the <i>NOS3</i> Gene with Chronic Kidney Disease of Uncertain or Non-Traditional Etiology in Mexican Patients |
| title_fullStr | Association between the Polymorphisms rs2070744, 4b/a and rs1799983 of the <i>NOS3</i> Gene with Chronic Kidney Disease of Uncertain or Non-Traditional Etiology in Mexican Patients |
| title_full_unstemmed | Association between the Polymorphisms rs2070744, 4b/a and rs1799983 of the <i>NOS3</i> Gene with Chronic Kidney Disease of Uncertain or Non-Traditional Etiology in Mexican Patients |
| title_short | Association between the Polymorphisms rs2070744, 4b/a and rs1799983 of the <i>NOS3</i> Gene with Chronic Kidney Disease of Uncertain or Non-Traditional Etiology in Mexican Patients |
| title_sort | association between the polymorphisms rs2070744 4b a and rs1799983 of the i nos3 i gene with chronic kidney disease of uncertain or non traditional etiology in mexican patients |
| topic | renal insufficiency chronic polymorphism genetic nitric oxide synthase type III |
| url | https://www.mdpi.com/1648-9144/59/5/829 |
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