Meta-analysis of TNF 308 G/A polymorphism and type 2 diabetes mellitus.
BACKGROUND AND OBJECTIVES: Many investigations have focused the association between TNF 308 G/A polymorphism and risk for type 2 diabetes mellitus (T2DM). However, the sample sizes of most of the studies were small. The aim of this study is to evaluate the precise association between this variant an...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3072982?pdf=render |
| _version_ | 1818194198844669952 |
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| author | Ren-Nan Feng Chen Zhao Chang-Hao Sun Ying Li |
| author_facet | Ren-Nan Feng Chen Zhao Chang-Hao Sun Ying Li |
| author_sort | Ren-Nan Feng |
| collection | DOAJ |
| description | BACKGROUND AND OBJECTIVES: Many investigations have focused the association between TNF 308 G/A polymorphism and risk for type 2 diabetes mellitus (T2DM). However, the sample sizes of most of the studies were small. The aim of this study is to evaluate the precise association between this variant and risk for T2DM in a large-scale meta-analysis. METHODS: All publications were searched on the association between TNF 308 G/A polymorphism and T2DM. The key words were as follows: diabetes, tumor necrosis factor and polymorphism/variant/genotype. This meta-analysis was assessed by Review manager 5.0. RESULTS: There were 18 studies identified. The odds ratios (ORs) and 95% confidence intervals (CI) for GA+AA versus GG genotype of TNF 308 G/A polymorphism were 1.03 (0.95-1.12), 1.03 (0.94-1.13) and 1.03 (0.78-1.36) in overall, Caucasian and Asian populations, respectively. The sensitivity analysis further strengthened the validity of this association. No publication bias or heterogeneity was observed in this study. CONCLUSION: In summary, there was no significant association detected between the TNF 308 G/A polymorphism and risk for T2DM. |
| first_indexed | 2024-12-12T00:58:29Z |
| format | Article |
| id | doaj.art-77776c01cf4f46928c38a1f80eb82854 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T00:58:29Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-77776c01cf4f46928c38a1f80eb828542022-12-22T00:43:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0164e1848010.1371/journal.pone.0018480Meta-analysis of TNF 308 G/A polymorphism and type 2 diabetes mellitus.Ren-Nan FengChen ZhaoChang-Hao SunYing LiBACKGROUND AND OBJECTIVES: Many investigations have focused the association between TNF 308 G/A polymorphism and risk for type 2 diabetes mellitus (T2DM). However, the sample sizes of most of the studies were small. The aim of this study is to evaluate the precise association between this variant and risk for T2DM in a large-scale meta-analysis. METHODS: All publications were searched on the association between TNF 308 G/A polymorphism and T2DM. The key words were as follows: diabetes, tumor necrosis factor and polymorphism/variant/genotype. This meta-analysis was assessed by Review manager 5.0. RESULTS: There were 18 studies identified. The odds ratios (ORs) and 95% confidence intervals (CI) for GA+AA versus GG genotype of TNF 308 G/A polymorphism were 1.03 (0.95-1.12), 1.03 (0.94-1.13) and 1.03 (0.78-1.36) in overall, Caucasian and Asian populations, respectively. The sensitivity analysis further strengthened the validity of this association. No publication bias or heterogeneity was observed in this study. CONCLUSION: In summary, there was no significant association detected between the TNF 308 G/A polymorphism and risk for T2DM.http://europepmc.org/articles/PMC3072982?pdf=render |
| spellingShingle | Ren-Nan Feng Chen Zhao Chang-Hao Sun Ying Li Meta-analysis of TNF 308 G/A polymorphism and type 2 diabetes mellitus. PLoS ONE |
| title | Meta-analysis of TNF 308 G/A polymorphism and type 2 diabetes mellitus. |
| title_full | Meta-analysis of TNF 308 G/A polymorphism and type 2 diabetes mellitus. |
| title_fullStr | Meta-analysis of TNF 308 G/A polymorphism and type 2 diabetes mellitus. |
| title_full_unstemmed | Meta-analysis of TNF 308 G/A polymorphism and type 2 diabetes mellitus. |
| title_short | Meta-analysis of TNF 308 G/A polymorphism and type 2 diabetes mellitus. |
| title_sort | meta analysis of tnf 308 g a polymorphism and type 2 diabetes mellitus |
| url | http://europepmc.org/articles/PMC3072982?pdf=render |
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