Research in child and adolescent anxiety and depression: treatment uncertainties prioritised by youth and professionals [version 2; peer review: 2 approved]

Background: A starting point for evaluating the effectiveness of treatments should be to identify evidence gaps. Furthermore, such evaluations should consider the perspectives of patients, clinicians and carers to ensure relevance and potentially influence future research initiatives. Methods: Our a...

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Main Authors: Brynhildur Axelsdóttir, Ragnhild Thoner, Lise Mette Eidet, Astrid Dahlgren, Ingrid Borren, Sølvi Biedilæ, Kristine Horseng Ludvigsen, Mari Elvsåshagen
Format: Article
Language:English
Published: F1000 Research Ltd 2022-05-01
Series:F1000Research
Subjects:
Online Access:https://f1000research.com/articles/10-1221/v2
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author Brynhildur Axelsdóttir
Ragnhild Thoner
Lise Mette Eidet
Astrid Dahlgren
Ingrid Borren
Sølvi Biedilæ
Kristine Horseng Ludvigsen
Mari Elvsåshagen
author_facet Brynhildur Axelsdóttir
Ragnhild Thoner
Lise Mette Eidet
Astrid Dahlgren
Ingrid Borren
Sølvi Biedilæ
Kristine Horseng Ludvigsen
Mari Elvsåshagen
author_sort Brynhildur Axelsdóttir
collection DOAJ
description Background: A starting point for evaluating the effectiveness of treatments should be to identify evidence gaps. Furthermore, such evaluations should consider the perspectives of patients, clinicians and carers to ensure relevance and potentially influence future research initiatives. Methods: Our approach, inspired by the James Lind Alliance methods, involved three steps. First, we performed a document analysis by identifying interventions and outcomes in two recently published overviews of systematic reviews, which summarised the effects of interventions for anxiety and depression in children and adolescents. Second, we surveyed children and adolescents with personal experiences of depression or anxiety as well as clinicians, and asked them to suggest treatments and outcomes associated with uncertainty. Finally, we facilitated a consensus process where clinicians and youth mental health patient representatives were invited to prioritise research uncertainties in separate consensus processes. Results: The survey included 674 respondents who reported a total of 1267 uncertainties. Independent coding by four investigators revealed 134 suggestions for treatments of anxiety, 90 suggestions for treatments of depression, 84 for outcomes of interventions for anxiety and 71 suggestions for outcomes of interventions for depression. Two separate priority setting workshops with eight clinicians and ten youth resulted in four independent top ten priority lists. Conclusion: Top ten lists of treatments and outcome domains of anxiety and depression in children and adolescents was identified by youth and clinicians. The results may influence the research agenda, and ultimately benefit patients.
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spelling doaj.art-7778480619d14ac1819c66926b996d5a2022-12-22T01:32:54ZengF1000 Research LtdF1000Research2046-14022022-05-0110133634Research in child and adolescent anxiety and depression: treatment uncertainties prioritised by youth and professionals [version 2; peer review: 2 approved]Brynhildur Axelsdóttir0https://orcid.org/0000-0002-4369-4175Ragnhild Thoner1Lise Mette Eidet2Astrid Dahlgren3https://orcid.org/0000-0002-6377-3321Ingrid Borren4https://orcid.org/0000-0002-7514-1743Sølvi Biedilæ5https://orcid.org/0000-0002-3014-0210Kristine Horseng Ludvigsen6Mari Elvsåshagen7Regional Centre for Child and Adolescent Mental Health, Eastern and Southern Norway, Oslo, 0484, NorwayRegional Centre for Child and Adolescent Mental Health, Eastern and Southern Norway, Oslo, 0484, NorwayRegional Centre for Child and Adolescent Mental Health, Eastern and Southern Norway, Oslo, 0484, NorwayRegional Centre for Child and Adolescent Mental Health, Eastern and Southern Norway, Oslo, 0484, NorwayRegional Centre for Child and Adolescent Mental Health, Eastern and Southern Norway, Oslo, 0484, NorwayRegional Centre for Child and Adolescent Mental Health, Eastern and Southern Norway, Oslo, 0484, NorwayRegional Centre for Child and Adolescent Mental Health, Eastern and Southern Norway, Oslo, 0484, NorwayRegional Centre for Child and Adolescent Mental Health, Eastern and Southern Norway, Oslo, 0484, NorwayBackground: A starting point for evaluating the effectiveness of treatments should be to identify evidence gaps. Furthermore, such evaluations should consider the perspectives of patients, clinicians and carers to ensure relevance and potentially influence future research initiatives. Methods: Our approach, inspired by the James Lind Alliance methods, involved three steps. First, we performed a document analysis by identifying interventions and outcomes in two recently published overviews of systematic reviews, which summarised the effects of interventions for anxiety and depression in children and adolescents. Second, we surveyed children and adolescents with personal experiences of depression or anxiety as well as clinicians, and asked them to suggest treatments and outcomes associated with uncertainty. Finally, we facilitated a consensus process where clinicians and youth mental health patient representatives were invited to prioritise research uncertainties in separate consensus processes. Results: The survey included 674 respondents who reported a total of 1267 uncertainties. Independent coding by four investigators revealed 134 suggestions for treatments of anxiety, 90 suggestions for treatments of depression, 84 for outcomes of interventions for anxiety and 71 suggestions for outcomes of interventions for depression. Two separate priority setting workshops with eight clinicians and ten youth resulted in four independent top ten priority lists. Conclusion: Top ten lists of treatments and outcome domains of anxiety and depression in children and adolescents was identified by youth and clinicians. The results may influence the research agenda, and ultimately benefit patients.https://f1000research.com/articles/10-1221/v2Anxiety Depression Children Adolescents Research priorities Consensus.eng
spellingShingle Brynhildur Axelsdóttir
Ragnhild Thoner
Lise Mette Eidet
Astrid Dahlgren
Ingrid Borren
Sølvi Biedilæ
Kristine Horseng Ludvigsen
Mari Elvsåshagen
Research in child and adolescent anxiety and depression: treatment uncertainties prioritised by youth and professionals [version 2; peer review: 2 approved]
F1000Research
Anxiety
Depression
Children
Adolescents
Research priorities
Consensus.
eng
title Research in child and adolescent anxiety and depression: treatment uncertainties prioritised by youth and professionals [version 2; peer review: 2 approved]
title_full Research in child and adolescent anxiety and depression: treatment uncertainties prioritised by youth and professionals [version 2; peer review: 2 approved]
title_fullStr Research in child and adolescent anxiety and depression: treatment uncertainties prioritised by youth and professionals [version 2; peer review: 2 approved]
title_full_unstemmed Research in child and adolescent anxiety and depression: treatment uncertainties prioritised by youth and professionals [version 2; peer review: 2 approved]
title_short Research in child and adolescent anxiety and depression: treatment uncertainties prioritised by youth and professionals [version 2; peer review: 2 approved]
title_sort research in child and adolescent anxiety and depression treatment uncertainties prioritised by youth and professionals version 2 peer review 2 approved
topic Anxiety
Depression
Children
Adolescents
Research priorities
Consensus.
eng
url https://f1000research.com/articles/10-1221/v2
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