From Prebiotic Chemistry to Supramolecular Biomedical Materials: Exploring the Properties of Self-Assembling Nucleobase-Containing Peptides
Peptides and their synthetic analogs are a class of molecules with enormous relevance as therapeutics for their ability to interact with biomacromolecules like nucleic acids and proteins, potentially interfering with biological pathways often involved in the onset and progression of pathologies of h...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/12/3558 |
| _version_ | 1797530603218796544 |
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| author | Pasqualina Liana Scognamiglio Chiara Platella Ettore Napolitano Domenica Musumeci Giovanni Nicola Roviello |
| author_facet | Pasqualina Liana Scognamiglio Chiara Platella Ettore Napolitano Domenica Musumeci Giovanni Nicola Roviello |
| author_sort | Pasqualina Liana Scognamiglio |
| collection | DOAJ |
| description | Peptides and their synthetic analogs are a class of molecules with enormous relevance as therapeutics for their ability to interact with biomacromolecules like nucleic acids and proteins, potentially interfering with biological pathways often involved in the onset and progression of pathologies of high social impact. Nucleobase-bearing peptides (nucleopeptides) and pseudopeptides (PNAs) offer further interesting possibilities related to their nucleobase-decorated nature for diagnostic and therapeutic applications, thanks to their reported ability to target complementary DNA and RNA strands. In addition, these chimeric compounds are endowed with intriguing self-assembling properties, which are at the heart of their investigation as self-replicating materials in prebiotic chemistry, as well as their application as constituents of innovative drug delivery systems and, more generally, as novel nanomaterials to be employed in biomedicine. Herein we describe the properties of nucleopeptides, PNAs and related supramolecular systems, and summarize some of the most relevant applications of these systems. |
| first_indexed | 2024-03-10T10:31:19Z |
| format | Article |
| id | doaj.art-777b280f684b48549278643b0687b35b |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T10:31:19Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-777b280f684b48549278643b0687b35b2023-11-21T23:38:50ZengMDPI AGMolecules1420-30492021-06-012612355810.3390/molecules26123558From Prebiotic Chemistry to Supramolecular Biomedical Materials: Exploring the Properties of Self-Assembling Nucleobase-Containing PeptidesPasqualina Liana Scognamiglio0Chiara Platella1Ettore Napolitano2Domenica Musumeci3Giovanni Nicola Roviello4Center for Advanced Biomaterial for Health Care (CABHC), Istituto Italiano di Tecnologia, I-80125 Naples, ItalyDepartment of Chemical Sciences, University of Naples Federico II, via Cintia 21, I-80126 Naples, ItalyDepartment of Chemical Sciences, University of Naples Federico II, via Cintia 21, I-80126 Naples, ItalyDepartment of Chemical Sciences, University of Naples Federico II, via Cintia 21, I-80126 Naples, ItalyIstituto di Biostrutture e Bioimmagini IBB-CNR, via Tommaso De Amicis 95, I-80145 Naples, ItalyPeptides and their synthetic analogs are a class of molecules with enormous relevance as therapeutics for their ability to interact with biomacromolecules like nucleic acids and proteins, potentially interfering with biological pathways often involved in the onset and progression of pathologies of high social impact. Nucleobase-bearing peptides (nucleopeptides) and pseudopeptides (PNAs) offer further interesting possibilities related to their nucleobase-decorated nature for diagnostic and therapeutic applications, thanks to their reported ability to target complementary DNA and RNA strands. In addition, these chimeric compounds are endowed with intriguing self-assembling properties, which are at the heart of their investigation as self-replicating materials in prebiotic chemistry, as well as their application as constituents of innovative drug delivery systems and, more generally, as novel nanomaterials to be employed in biomedicine. Herein we describe the properties of nucleopeptides, PNAs and related supramolecular systems, and summarize some of the most relevant applications of these systems.https://www.mdpi.com/1420-3049/26/12/3558peptidesnucleobasesbioactivitynucleopeptidesPNAsnucleic acids |
| spellingShingle | Pasqualina Liana Scognamiglio Chiara Platella Ettore Napolitano Domenica Musumeci Giovanni Nicola Roviello From Prebiotic Chemistry to Supramolecular Biomedical Materials: Exploring the Properties of Self-Assembling Nucleobase-Containing Peptides Molecules peptides nucleobases bioactivity nucleopeptides PNAs nucleic acids |
| title | From Prebiotic Chemistry to Supramolecular Biomedical Materials: Exploring the Properties of Self-Assembling Nucleobase-Containing Peptides |
| title_full | From Prebiotic Chemistry to Supramolecular Biomedical Materials: Exploring the Properties of Self-Assembling Nucleobase-Containing Peptides |
| title_fullStr | From Prebiotic Chemistry to Supramolecular Biomedical Materials: Exploring the Properties of Self-Assembling Nucleobase-Containing Peptides |
| title_full_unstemmed | From Prebiotic Chemistry to Supramolecular Biomedical Materials: Exploring the Properties of Self-Assembling Nucleobase-Containing Peptides |
| title_short | From Prebiotic Chemistry to Supramolecular Biomedical Materials: Exploring the Properties of Self-Assembling Nucleobase-Containing Peptides |
| title_sort | from prebiotic chemistry to supramolecular biomedical materials exploring the properties of self assembling nucleobase containing peptides |
| topic | peptides nucleobases bioactivity nucleopeptides PNAs nucleic acids |
| url | https://www.mdpi.com/1420-3049/26/12/3558 |
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