Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole Derivatives

Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole Derivatives

Benzylcyanide and 4-nitrobenzylcyanide condensed with triethyl orthoformate and piperidine or morpholine to yield 2-aryl-2-piperidinyl or 2-morpholinylacrylonitriles. These coupled with aromatic diazonium salts to yield the 2-arylhydrazno-2-arylethane nitriles in good yields. The latter were convert...

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Bibliographic Details
Main Authors: Abdellatif Mohamed Salaheldin, Mariam Abdullah Al-Sheikh, Hanadi Y. Medrasi
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:Molecules
Subjects:
enaminonitriles
4-aminopyrazole
Thorpe-Ziegler cyclization
microwave irradiation
Online Access:http://www.mdpi.com/1420-3049/18/1/535
Description
Summary:Benzylcyanide and 4-nitrobenzylcyanide condensed with triethyl orthoformate and piperidine or morpholine to yield 2-aryl-2-piperidinyl or 2-morpholinylacrylonitriles. These coupled with aromatic diazonium salts to yield the 2-arylhydrazno-2-arylethane nitriles in good yields. The latter were converted into 4-aminopyrazoles in good yields using the Thorpe-Ziegler cyclization.
ISSN:1420-3049

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