Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole Derivatives
Benzylcyanide and 4-nitrobenzylcyanide condensed with triethyl orthoformate and piperidine or morpholine to yield 2-aryl-2-piperidinyl or 2-morpholinylacrylonitriles. These coupled with aromatic diazonium salts to yield the 2-arylhydrazno-2-arylethane nitriles in good yields. The latter were convert...
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-01-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/18/1/535 |
| _version_ | 1818591453284139008 |
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| author | Abdellatif Mohamed Salaheldin Mariam Abdullah Al-Sheikh Hanadi Y. Medrasi |
| author_facet | Abdellatif Mohamed Salaheldin Mariam Abdullah Al-Sheikh Hanadi Y. Medrasi |
| author_sort | Abdellatif Mohamed Salaheldin |
| collection | DOAJ |
| description | Benzylcyanide and 4-nitrobenzylcyanide condensed with triethyl orthoformate and piperidine or morpholine to yield 2-aryl-2-piperidinyl or 2-morpholinylacrylonitriles. These coupled with aromatic diazonium salts to yield the 2-arylhydrazno-2-arylethane nitriles in good yields. The latter were converted into 4-aminopyrazoles in good yields using the Thorpe-Ziegler cyclization. |
| first_indexed | 2024-12-16T10:12:41Z |
| format | Article |
| id | doaj.art-777cc1af921a4e7db8e42689c4460436 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-16T10:12:41Z |
| publishDate | 2013-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-777cc1af921a4e7db8e42689c44604362022-12-21T22:35:32ZengMDPI AGMolecules1420-30492013-01-0118153554410.3390/molecules18010535Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole DerivativesAbdellatif Mohamed SalaheldinMariam Abdullah Al-SheikhHanadi Y. MedrasiBenzylcyanide and 4-nitrobenzylcyanide condensed with triethyl orthoformate and piperidine or morpholine to yield 2-aryl-2-piperidinyl or 2-morpholinylacrylonitriles. These coupled with aromatic diazonium salts to yield the 2-arylhydrazno-2-arylethane nitriles in good yields. The latter were converted into 4-aminopyrazoles in good yields using the Thorpe-Ziegler cyclization.http://www.mdpi.com/1420-3049/18/1/535enaminonitriles4-aminopyrazoleThorpe-Ziegler cyclizationmicrowave irradiation |
| spellingShingle | Abdellatif Mohamed Salaheldin Mariam Abdullah Al-Sheikh Hanadi Y. Medrasi Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole Derivatives Molecules enaminonitriles 4-aminopyrazole Thorpe-Ziegler cyclization microwave irradiation |
| title | Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole Derivatives |
| title_full | Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole Derivatives |
| title_fullStr | Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole Derivatives |
| title_full_unstemmed | Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole Derivatives |
| title_short | Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole Derivatives |
| title_sort | enaminonitriles in heterocyclic synthesis a route to 1 3 diaryl 4 aminopyrazole derivatives |
| topic | enaminonitriles 4-aminopyrazole Thorpe-Ziegler cyclization microwave irradiation |
| url | http://www.mdpi.com/1420-3049/18/1/535 |
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