Role of Granulosa Cells in the Aging Ovarian Landscape: A Focus on Mitochondrial and Metabolic Function
Mitochondria are at the intersection of aging and fertility, with research efforts centered largely on the role that these specialized organelles play in the relatively rapid decline in oocyte quality that occurs as females approach reproductive senescence. In addition to various roles in oocyte mat...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.800739/full |
| _version_ | 1818332454065274880 |
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| author | Hannah C. Alberico Dori C. Woods |
| author_facet | Hannah C. Alberico Dori C. Woods |
| author_sort | Hannah C. Alberico |
| collection | DOAJ |
| description | Mitochondria are at the intersection of aging and fertility, with research efforts centered largely on the role that these specialized organelles play in the relatively rapid decline in oocyte quality that occurs as females approach reproductive senescence. In addition to various roles in oocyte maturation, fertilization, and embryogenesis, mitochondria are critical to granulosa cell function. Herein, we provide a review of the literature pertaining to the role of mitochondria in granulosa cell function, with emphasis on how mitochondrial aging in granulosa cells may impact reproduction in female mammals. |
| first_indexed | 2024-12-13T13:36:00Z |
| format | Article |
| id | doaj.art-778039415a944849824caecb88e56214 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-13T13:36:00Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-778039415a944849824caecb88e562142022-12-21T23:43:48ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-01-011210.3389/fphys.2021.800739800739Role of Granulosa Cells in the Aging Ovarian Landscape: A Focus on Mitochondrial and Metabolic FunctionHannah C. AlbericoDori C. WoodsMitochondria are at the intersection of aging and fertility, with research efforts centered largely on the role that these specialized organelles play in the relatively rapid decline in oocyte quality that occurs as females approach reproductive senescence. In addition to various roles in oocyte maturation, fertilization, and embryogenesis, mitochondria are critical to granulosa cell function. Herein, we provide a review of the literature pertaining to the role of mitochondria in granulosa cell function, with emphasis on how mitochondrial aging in granulosa cells may impact reproduction in female mammals.https://www.frontiersin.org/articles/10.3389/fphys.2021.800739/fullgranulosa cellsovarian agingmitochondriareproductionoocytes |
| spellingShingle | Hannah C. Alberico Dori C. Woods Role of Granulosa Cells in the Aging Ovarian Landscape: A Focus on Mitochondrial and Metabolic Function Frontiers in Physiology granulosa cells ovarian aging mitochondria reproduction oocytes |
| title | Role of Granulosa Cells in the Aging Ovarian Landscape: A Focus on Mitochondrial and Metabolic Function |
| title_full | Role of Granulosa Cells in the Aging Ovarian Landscape: A Focus on Mitochondrial and Metabolic Function |
| title_fullStr | Role of Granulosa Cells in the Aging Ovarian Landscape: A Focus on Mitochondrial and Metabolic Function |
| title_full_unstemmed | Role of Granulosa Cells in the Aging Ovarian Landscape: A Focus on Mitochondrial and Metabolic Function |
| title_short | Role of Granulosa Cells in the Aging Ovarian Landscape: A Focus on Mitochondrial and Metabolic Function |
| title_sort | role of granulosa cells in the aging ovarian landscape a focus on mitochondrial and metabolic function |
| topic | granulosa cells ovarian aging mitochondria reproduction oocytes |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.800739/full |
| work_keys_str_mv | AT hannahcalberico roleofgranulosacellsintheagingovarianlandscapeafocusonmitochondrialandmetabolicfunction AT doricwoods roleofgranulosacellsintheagingovarianlandscapeafocusonmitochondrialandmetabolicfunction |