Malignant acanthosis nigricans: a case report
Abstract Background To report a case of malignant acanthosis nigricans with two unusual aspects, including the patient’s young age and the development of filiform papillomas on the eyelid margins. Case presentation A 30-year-old woman presented with dry eye symptoms. Examination revealed filiform pa...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-11-01
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| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12886-020-01708-2 |
| _version_ | 1819170131875463168 |
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| author | Xiaoyan Zhang Rongjun Liu Yiyun Liu Shuang Zhang Hong Qi |
| author_facet | Xiaoyan Zhang Rongjun Liu Yiyun Liu Shuang Zhang Hong Qi |
| author_sort | Xiaoyan Zhang |
| collection | DOAJ |
| description | Abstract Background To report a case of malignant acanthosis nigricans with two unusual aspects, including the patient’s young age and the development of filiform papillomas on the eyelid margins. Case presentation A 30-year-old woman presented with dry eye symptoms. Examination revealed filiform papillomas on the eyelid margins, gums, lips, hands, and axillae and excessive pigmentation localized to the neck, axillae, and groin. Biopsies of stomach, pancreatic, and thyroid lesions revealed gastric adenocarcinoma, pancreatic adenocarcinoma, and thyroid cancer, respectively. Systemic investigations showed gastric adenocarcinoma with metastatic spread. The patient was ultimately diagnosed with malignant acanthosis nigricans and died 4 months later. Conclusions Acanthosis nigricans on the eyelid margins with a velvety overgrowth is highly suggestive of an internal malignancy, and full systemic investigations are warranted in these cases. In this patient, early signs were ignored, leading to the loss of a timely diagnosis and treatment. |
| first_indexed | 2024-12-22T19:30:31Z |
| format | Article |
| id | doaj.art-7780a0573765468295eb30a4f01e7ef4 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-22T19:30:31Z |
| publishDate | 2020-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-7780a0573765468295eb30a4f01e7ef42022-12-21T18:15:08ZengBMCBMC Ophthalmology1471-24152020-11-012011410.1186/s12886-020-01708-2Malignant acanthosis nigricans: a case reportXiaoyan Zhang0Rongjun Liu1Yiyun Liu2Shuang Zhang3Hong Qi4Department of Ophthalmology, Peking University Third HospitalDepartment of Ophthalmology, Peking University Third HospitalDepartment of Ophthalmology, Peking University Third HospitalDepartment of Pathology, Peking University First HospitalDepartment of Ophthalmology, Peking University Third HospitalAbstract Background To report a case of malignant acanthosis nigricans with two unusual aspects, including the patient’s young age and the development of filiform papillomas on the eyelid margins. Case presentation A 30-year-old woman presented with dry eye symptoms. Examination revealed filiform papillomas on the eyelid margins, gums, lips, hands, and axillae and excessive pigmentation localized to the neck, axillae, and groin. Biopsies of stomach, pancreatic, and thyroid lesions revealed gastric adenocarcinoma, pancreatic adenocarcinoma, and thyroid cancer, respectively. Systemic investigations showed gastric adenocarcinoma with metastatic spread. The patient was ultimately diagnosed with malignant acanthosis nigricans and died 4 months later. Conclusions Acanthosis nigricans on the eyelid margins with a velvety overgrowth is highly suggestive of an internal malignancy, and full systemic investigations are warranted in these cases. In this patient, early signs were ignored, leading to the loss of a timely diagnosis and treatment.http://link.springer.com/article/10.1186/s12886-020-01708-2Dry eye diseaseGastric adenocarcinomaMalignant acanthosis nigricansCase report |
| spellingShingle | Xiaoyan Zhang Rongjun Liu Yiyun Liu Shuang Zhang Hong Qi Malignant acanthosis nigricans: a case report BMC Ophthalmology Dry eye disease Gastric adenocarcinoma Malignant acanthosis nigricans Case report |
| title | Malignant acanthosis nigricans: a case report |
| title_full | Malignant acanthosis nigricans: a case report |
| title_fullStr | Malignant acanthosis nigricans: a case report |
| title_full_unstemmed | Malignant acanthosis nigricans: a case report |
| title_short | Malignant acanthosis nigricans: a case report |
| title_sort | malignant acanthosis nigricans a case report |
| topic | Dry eye disease Gastric adenocarcinoma Malignant acanthosis nigricans Case report |
| url | http://link.springer.com/article/10.1186/s12886-020-01708-2 |
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