PHOTOCHEMICAL REACTIONS OF FORMYLMETHYLFLAVIN AND RIBOFLAVIN
Formylmethylflavin (FMF) is a major intermediate product in the aerobic and anaerobic photolysis of riboflavin (RF) and is highly sensitive to light and hydrolysis. It is more sensitive to light as compared to RF. FMF is further degraded into lumichrome (LC), carboxymethylflavin (CMF) in acidic medi...
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Baqai University Press
2015-12-01
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| Series: | Baqai Journal of Health Sciences |
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| Online Access: | http://www.baqaiassets.com/bjhs/admin/articlefiles/1467271798upl6.pdf |
| _version_ | 1811204576470106112 |
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| author | Tania Mirza Zubair Anwar Samina Shiekh Iqbal Ahmad |
| author_facet | Tania Mirza Zubair Anwar Samina Shiekh Iqbal Ahmad |
| author_sort | Tania Mirza |
| collection | DOAJ |
| description | Formylmethylflavin (FMF) is a major intermediate product in the aerobic and anaerobic photolysis of riboflavin (RF) and is highly sensitive to light and hydrolysis. It is more sensitive to light as compared to RF. FMF is further degraded into lumichrome (LC), carboxymethylflavin (CMF) in acidic medium, and LC, CMF and lumiflavin (LF) in alkaline medium. When FMF is exposed to light it is degraded in to LC and LF via a photoreduction and CMF through photooxidation pathways. In aerobic and anaerobic conditions, RF when exposed to light is excited to singlet state (1RF) and from singlet to triplet state (3RF). This is followed by the conversion of 3RF into a semiquinone radical (RFH) and this radical further disproportionate to form an oxidized RF and a cyclic intermediate, which is further oxidized to FMF and degradation products (LC, LF, CMF). |
| first_indexed | 2024-04-12T03:16:27Z |
| format | Article |
| id | doaj.art-77816fa42ddc418e8959b08feb0b02a6 |
| institution | Directory Open Access Journal |
| issn | 2312-4423 2312-6884 |
| language | English |
| last_indexed | 2024-04-12T03:16:27Z |
| publishDate | 2015-12-01 |
| publisher | Baqai University Press |
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| series | Baqai Journal of Health Sciences |
| spelling | doaj.art-77816fa42ddc418e8959b08feb0b02a62022-12-22T03:50:07ZengBaqai University PressBaqai Journal of Health Sciences2312-44232312-68842015-12-011823034PHOTOCHEMICAL REACTIONS OF FORMYLMETHYLFLAVIN AND RIBOFLAVINTania Mirza0Zubair Anwar1Samina Shiekh2Iqbal Ahmad3Department of Pharmaceutical Chemistry, Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan & Corresponding Author Email: dr.tania_mirza12@hotmail.comDepartment of Pharmaceutical Chemistry, Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, PakistanDepartment of Pharmaceutics, Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, PakistanDepartment of Pharmaceutical Chemistry, Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, PakistanFormylmethylflavin (FMF) is a major intermediate product in the aerobic and anaerobic photolysis of riboflavin (RF) and is highly sensitive to light and hydrolysis. It is more sensitive to light as compared to RF. FMF is further degraded into lumichrome (LC), carboxymethylflavin (CMF) in acidic medium, and LC, CMF and lumiflavin (LF) in alkaline medium. When FMF is exposed to light it is degraded in to LC and LF via a photoreduction and CMF through photooxidation pathways. In aerobic and anaerobic conditions, RF when exposed to light is excited to singlet state (1RF) and from singlet to triplet state (3RF). This is followed by the conversion of 3RF into a semiquinone radical (RFH) and this radical further disproportionate to form an oxidized RF and a cyclic intermediate, which is further oxidized to FMF and degradation products (LC, LF, CMF).http://www.baqaiassets.com/bjhs/admin/articlefiles/1467271798upl6.pdfFormylmethylflavinriboflavinaerobic and anaerobicphotolysis. |
| spellingShingle | Tania Mirza Zubair Anwar Samina Shiekh Iqbal Ahmad PHOTOCHEMICAL REACTIONS OF FORMYLMETHYLFLAVIN AND RIBOFLAVIN Baqai Journal of Health Sciences Formylmethylflavin riboflavin aerobic and anaerobicphotolysis. |
| title | PHOTOCHEMICAL REACTIONS OF FORMYLMETHYLFLAVIN AND RIBOFLAVIN |
| title_full | PHOTOCHEMICAL REACTIONS OF FORMYLMETHYLFLAVIN AND RIBOFLAVIN |
| title_fullStr | PHOTOCHEMICAL REACTIONS OF FORMYLMETHYLFLAVIN AND RIBOFLAVIN |
| title_full_unstemmed | PHOTOCHEMICAL REACTIONS OF FORMYLMETHYLFLAVIN AND RIBOFLAVIN |
| title_short | PHOTOCHEMICAL REACTIONS OF FORMYLMETHYLFLAVIN AND RIBOFLAVIN |
| title_sort | photochemical reactions of formylmethylflavin and riboflavin |
| topic | Formylmethylflavin riboflavin aerobic and anaerobicphotolysis. |
| url | http://www.baqaiassets.com/bjhs/admin/articlefiles/1467271798upl6.pdf |
| work_keys_str_mv | AT taniamirza photochemicalreactionsofformylmethylflavinandriboflavin AT zubairanwar photochemicalreactionsofformylmethylflavinandriboflavin AT saminashiekh photochemicalreactionsofformylmethylflavinandriboflavin AT iqbalahmad photochemicalreactionsofformylmethylflavinandriboflavin |