Hepatitis C Virus Micro-Elimination Plan in Southern Italy: The “HCV ICEberg” Project
This study evaluates the feasibility of a local action program for HCV micro-elimination in highly endemic areas. Retrospective analysis: administrative and laboratory data (Local Health Unit, southern Italy) were integrated to quantize the anti-HCV-positive subjects not RNA tested and untreated HCV...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/12/2/195 |
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| author | Carmine Coppola Loreta A. Kondili Laura Staiano Simona Cammarota Anna Citarella Mirko Pio Aloisio Angelo Annunziata Francesca Futura Bernardi Aldo D’Avino Michele D’Orazio Marianna Fogliasecca Mario Fusco Federica Pisano Adriano Vercellone Elvira Bianco Ugo Trama |
| author_facet | Carmine Coppola Loreta A. Kondili Laura Staiano Simona Cammarota Anna Citarella Mirko Pio Aloisio Angelo Annunziata Francesca Futura Bernardi Aldo D’Avino Michele D’Orazio Marianna Fogliasecca Mario Fusco Federica Pisano Adriano Vercellone Elvira Bianco Ugo Trama |
| author_sort | Carmine Coppola |
| collection | DOAJ |
| description | This study evaluates the feasibility of a local action program for HCV micro-elimination in highly endemic areas. Retrospective analysis: administrative and laboratory data (Local Health Unit, southern Italy) were integrated to quantize the anti-HCV-positive subjects not RNA tested and untreated HCV-infected subjects (2018–2022). Prospective analysis: all subjects admitted to a division of the LHU largest hospital (2021–2022) were tested for HCV, with linkage of active-infected patients to care. Overall, 49287 subjects were HCV-Ab tested: 1071 (2.2%) resulted positive without information for an HCV RNA test and 230 (0.5%) had an active infection not yet cured. Among 856 admitted subjects, 54 (6.3%) were HCV-Ab+ and 27 (3.0%) HCV RNA+. Of HCV-infected patients, 22.2% had advanced liver disease, highlighting the need for earlier diagnosis; 27.7% were unaware of HCV infection; and 20.4% were previously aware but never referred to a clinical center. Of these, 26% died and 74% received treatment. Our study emphasizes the value of an active HCV hospital case-finding program to enhance diagnosis in patients with several comorbidities and to easily link them to care. Our data strongly suggest extending this program to all hospital wards/access as a standard of care, particularly in highly endemic areas, to help HCV disease control and take steps in achieving the elimination goals. |
| first_indexed | 2024-03-11T08:18:59Z |
| format | Article |
| id | doaj.art-77824082374341c38499ea0ba877a539 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-11T08:18:59Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-77824082374341c38499ea0ba877a5392023-11-16T22:33:25ZengMDPI AGPathogens2076-08172023-01-0112219510.3390/pathogens12020195Hepatitis C Virus Micro-Elimination Plan in Southern Italy: The “HCV ICEberg” ProjectCarmine Coppola0Loreta A. Kondili1Laura Staiano2Simona Cammarota3Anna Citarella4Mirko Pio Aloisio5Angelo Annunziata6Francesca Futura Bernardi7Aldo D’Avino8Michele D’Orazio9Marianna Fogliasecca10Mario Fusco11Federica Pisano12Adriano Vercellone13Elvira Bianco14Ugo Trama15Department of Internal Medicine, Unit of Hepatology and Interventional Ultrasonography, OORR Area Stabiese, 80054 Gragnano, ItalyCenter for Global Health, Istituto Superiore di Sanità, 00161 Rome, ItalyDepartment of Internal Medicine, Unit of Hepatology and Interventional Ultrasonography, OORR Area Stabiese, 80054 Gragnano, ItalyLinkHealth Health Economics, Outcomes & Epidemiology S.R.L., 80143 Naples, ItalyLinkHealth Health Economics, Outcomes & Epidemiology S.R.L., 80143 Naples, ItalyLocal Health Unit Naples 3 South, 80059 Castellammare di Stabia, ItalyLocal Health Unit Naples 3 South, 80059 Castellammare di Stabia, ItalyGeneral Direction of Health Care & Regional Health System Coordination, Drug & Device Politics, Campania Region, 80143 Naples, ItalyLocal Health Unit Naples 3 South, 80059 Castellammare di Stabia, ItalyLocal Health Unit Naples 3 South, 80059 Castellammare di Stabia, ItalyLinkHealth Health Economics, Outcomes & Epidemiology S.R.L., 80143 Naples, ItalyCancer Registry, Local Health Unit Naples 3 South, 80100 Naples, ItalyDepartment of Internal Medicine, Unit of Hepatology and Interventional Ultrasonography, OORR Area Stabiese, 80054 Gragnano, ItalyPharmacy Unit, Local Health Unit Naples 3 South, 80059 Castellammare di Stabia, ItalyHealthcare Direction, Local Health Unit Naples 3 South, 80059 Castellammare di Stabia, ItalyGeneral Direction of Health Care & Regional Health System Coordination, Drug & Device Politics, Campania Region, 80143 Naples, ItalyThis study evaluates the feasibility of a local action program for HCV micro-elimination in highly endemic areas. Retrospective analysis: administrative and laboratory data (Local Health Unit, southern Italy) were integrated to quantize the anti-HCV-positive subjects not RNA tested and untreated HCV-infected subjects (2018–2022). Prospective analysis: all subjects admitted to a division of the LHU largest hospital (2021–2022) were tested for HCV, with linkage of active-infected patients to care. Overall, 49287 subjects were HCV-Ab tested: 1071 (2.2%) resulted positive without information for an HCV RNA test and 230 (0.5%) had an active infection not yet cured. Among 856 admitted subjects, 54 (6.3%) were HCV-Ab+ and 27 (3.0%) HCV RNA+. Of HCV-infected patients, 22.2% had advanced liver disease, highlighting the need for earlier diagnosis; 27.7% were unaware of HCV infection; and 20.4% were previously aware but never referred to a clinical center. Of these, 26% died and 74% received treatment. Our study emphasizes the value of an active HCV hospital case-finding program to enhance diagnosis in patients with several comorbidities and to easily link them to care. Our data strongly suggest extending this program to all hospital wards/access as a standard of care, particularly in highly endemic areas, to help HCV disease control and take steps in achieving the elimination goals.https://www.mdpi.com/2076-0817/12/2/195administrative datacascade of careopportunistic screeninglinkage to careHCV micro-elimination |
| spellingShingle | Carmine Coppola Loreta A. Kondili Laura Staiano Simona Cammarota Anna Citarella Mirko Pio Aloisio Angelo Annunziata Francesca Futura Bernardi Aldo D’Avino Michele D’Orazio Marianna Fogliasecca Mario Fusco Federica Pisano Adriano Vercellone Elvira Bianco Ugo Trama Hepatitis C Virus Micro-Elimination Plan in Southern Italy: The “HCV ICEberg” Project Pathogens administrative data cascade of care opportunistic screening linkage to care HCV micro-elimination |
| title | Hepatitis C Virus Micro-Elimination Plan in Southern Italy: The “HCV ICEberg” Project |
| title_full | Hepatitis C Virus Micro-Elimination Plan in Southern Italy: The “HCV ICEberg” Project |
| title_fullStr | Hepatitis C Virus Micro-Elimination Plan in Southern Italy: The “HCV ICEberg” Project |
| title_full_unstemmed | Hepatitis C Virus Micro-Elimination Plan in Southern Italy: The “HCV ICEberg” Project |
| title_short | Hepatitis C Virus Micro-Elimination Plan in Southern Italy: The “HCV ICEberg” Project |
| title_sort | hepatitis c virus micro elimination plan in southern italy the hcv iceberg project |
| topic | administrative data cascade of care opportunistic screening linkage to care HCV micro-elimination |
| url | https://www.mdpi.com/2076-0817/12/2/195 |
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