Non-homologous end-joining pathway associated with occurrence of myocardial infarction: gene set analysis of genome-wide association study data.

Non-homologous end-joining pathway associated with occurrence of myocardial infarction: gene set analysis of genome-wide association study data.

PURPOSE: DNA repair deficiencies have been postulated to play a role in the development and progression of cardiovascular disease (CVD). The hypothesis is that DNA damage accumulating with age may induce cell death, which promotes formation of unstable plaques. Defects in DNA repair mechanisms may t...

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Main Authors: Jeffrey J W Verschuren, Stella Trompet, Joris Deelen, David J Stott, Naveed Sattar, Brendan M Buckley, Ian Ford, Bastiaan T Heijmans, Henk-Jan Guchelaar, Jeanine J Houwing-Duistermaat, P Eline Slagboom, J Wouter Jukema
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3574159?pdf=render

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