Effects of smoking cessation on HDL functionality
Objective Cigarette smoking is positively correlated with the morbidity of cardiovascular diseases (CVD). It was reported that reduced high density lipoprotein (HDL) functionality is one of the causes of CVD. In this study, we hypothesized that smoking cessation could lead to improved HDL functions,...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
European Publishing
2019-10-01
|
| Series: | Tobacco Induced Diseases |
| Subjects: | |
| Online Access: | http://www.journalssystem.com/tid/,111387,0,2.html |
| _version_ | 1818567387065090048 |
|---|---|
| author | Emi Kawachi Kohei Takata Satoshi Imaizumi Shin-ichiro Miura Keijiro Saku |
| author_facet | Emi Kawachi Kohei Takata Satoshi Imaizumi Shin-ichiro Miura Keijiro Saku |
| author_sort | Emi Kawachi |
| collection | DOAJ |
| description | Objective
Cigarette smoking is positively correlated with the morbidity
of cardiovascular diseases (CVD). It was reported that
reduced high density lipoprotein (HDL) functionality is one
of the causes of CVD. In this study, we hypothesized that
smoking cessation could lead to improved HDL functions,
and evaluated the cholesterol efflux capacity, antioxidative
capacity of HDL in participants before and after smoking
cessation.
Methods
Thirty-two Japanese adult smokers aged were enrolled
for treatment at the Smoking Cessation Clinic of Fukuoka
University Hospital. Participants either received varenicline
for 12 weeks or wore a transdermal nicotine patch on
their chest for 8 weeks. Successful smoking cessation
was identified by both a self-assessment report and
the end-expiratory carbon monoxide (CO) concentration
(under 8ppm). Plasma lipid profiles, plasma and HDL
malondialdehyde (MDA) levels, HDL subfractions as
analyzed by capillary isotachophoresis, cholesterol efflux
capacity and antioxidative capacity of HDL were measured
before and after this intervention.
Results
After smoking cessation, HDL-C, apoA-I levels and HDL
subfractions did not significantly change. Nevertheless,
cholesterol efflux capacity and the antioxidative capacity of
HDL were significantly improved in the successful smoking
cessation group. The extent of the changes in cholesterol
efflux capacity and antioxidative capacity of HDL correlated
with those in the end-expiratory CO concentration and
MDA in HDL, respectively.
Conclusions
Our findings indicate that cigarette smoking impairs HDL
function and smoking cessation restores it. This may be
one of the mechanisms by which smoking cessation has
beneficial effects against CVD. |
| first_indexed | 2024-12-14T06:22:44Z |
| format | Article |
| id | doaj.art-778552c803894c81a95409550f30590d |
| institution | Directory Open Access Journal |
| issn | 1617-9625 |
| language | English |
| last_indexed | 2024-12-14T06:22:44Z |
| publishDate | 2019-10-01 |
| publisher | European Publishing |
| record_format | Article |
| series | Tobacco Induced Diseases |
| spelling | doaj.art-778552c803894c81a95409550f30590d2022-12-21T23:13:46ZengEuropean PublishingTobacco Induced Diseases1617-96252019-10-0117110.18332/tid/111387111387Effects of smoking cessation on HDL functionalityEmi Kawachi0Kohei Takata1Satoshi Imaizumi2Shin-ichiro Miura3Keijiro Saku4Department of Cardiology, School of Medicine, Fukuoka University, Fukuoka, JapanDepartment of Cardiology, School of Medicine, Fukuoka University, Fukuoka, JapanDepartment of Cardiology, School of Medicine, Fukuoka University, Fukuoka, JapanDepartment of Cardiology, School of Medicine, Fukuoka University, Fukuoka, JapanDepartment of Cardiology, School of Medicine, Fukuoka University, Fukuoka, JapanObjective Cigarette smoking is positively correlated with the morbidity of cardiovascular diseases (CVD). It was reported that reduced high density lipoprotein (HDL) functionality is one of the causes of CVD. In this study, we hypothesized that smoking cessation could lead to improved HDL functions, and evaluated the cholesterol efflux capacity, antioxidative capacity of HDL in participants before and after smoking cessation. Methods Thirty-two Japanese adult smokers aged were enrolled for treatment at the Smoking Cessation Clinic of Fukuoka University Hospital. Participants either received varenicline for 12 weeks or wore a transdermal nicotine patch on their chest for 8 weeks. Successful smoking cessation was identified by both a self-assessment report and the end-expiratory carbon monoxide (CO) concentration (under 8ppm). Plasma lipid profiles, plasma and HDL malondialdehyde (MDA) levels, HDL subfractions as analyzed by capillary isotachophoresis, cholesterol efflux capacity and antioxidative capacity of HDL were measured before and after this intervention. Results After smoking cessation, HDL-C, apoA-I levels and HDL subfractions did not significantly change. Nevertheless, cholesterol efflux capacity and the antioxidative capacity of HDL were significantly improved in the successful smoking cessation group. The extent of the changes in cholesterol efflux capacity and antioxidative capacity of HDL correlated with those in the end-expiratory CO concentration and MDA in HDL, respectively. Conclusions Our findings indicate that cigarette smoking impairs HDL function and smoking cessation restores it. This may be one of the mechanisms by which smoking cessation has beneficial effects against CVD.http://www.journalssystem.com/tid/,111387,0,2.htmlsmoking cessationHDL function |
| spellingShingle | Emi Kawachi Kohei Takata Satoshi Imaizumi Shin-ichiro Miura Keijiro Saku Effects of smoking cessation on HDL functionality Tobacco Induced Diseases smoking cessation HDL function |
| title | Effects of smoking cessation on HDL
functionality |
| title_full | Effects of smoking cessation on HDL
functionality |
| title_fullStr | Effects of smoking cessation on HDL
functionality |
| title_full_unstemmed | Effects of smoking cessation on HDL
functionality |
| title_short | Effects of smoking cessation on HDL
functionality |
| title_sort | effects of smoking cessation on hdl functionality |
| topic | smoking cessation HDL function |
| url | http://www.journalssystem.com/tid/,111387,0,2.html |
| work_keys_str_mv | AT emikawachi effectsofsmokingcessationonhdlfunctionality AT koheitakata effectsofsmokingcessationonhdlfunctionality AT satoshiimaizumi effectsofsmokingcessationonhdlfunctionality AT shinichiromiura effectsofsmokingcessationonhdlfunctionality AT keijirosaku effectsofsmokingcessationonhdlfunctionality |