An epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis.
Studies on familial aggregation of cancer may suggest an overall contribution of inherited genes or a shared environment in the development of malignant disease. We performed a meta-analysis on familial clustering of prostate cancer. Out of 74 studies reporting data on familial aggregation of prosta...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22073129/pdf/?tool=EBI |
| _version_ | 1818399660565331968 |
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| author | Michał Kiciński Jaco Vangronsveld Tim S Nawrot |
| author_facet | Michał Kiciński Jaco Vangronsveld Tim S Nawrot |
| author_sort | Michał Kiciński |
| collection | DOAJ |
| description | Studies on familial aggregation of cancer may suggest an overall contribution of inherited genes or a shared environment in the development of malignant disease. We performed a meta-analysis on familial clustering of prostate cancer. Out of 74 studies reporting data on familial aggregation of prostate cancer in unselected populations retrieved by a Pubmed search and browsing references, 33 independent studies meeting the inclusion criteria were used in the analysis performed with the random effects model. The pooled rate ratio (RR) for first-degree family history, i.e. affected father or brother, is 2.48 (95% confidence interval: 2.25-2.74). The incidence rate for men who have a brother who got prostate cancer increases 3.14 times (CI:2.37-4.15), and for those with affected father 2.35 times (CI:2.02-2.72). The pooled estimate of RR for two or more affected first-degree family members relative to no history in father and in brother is 4.39 (CI:2.61-7.39). First-degree family history appears to increase the incidence rate of prostate cancer more in men under 65 (RR:2.87, CI:2.21-3.74), than in men aged 65 and older (RR:1.92, CI:1.49-2.47), p for interaction = 0.002. The attributable fraction among those having an affected first-degree relative equals to 59.7% (CI:55.6-63.5%) for men at all ages, 65.2% (CI:57.7-71.4%) for men younger than 65 and 47.9% (CI:37.1-56.8%) for men aged 65 or older. For those with a family history in 2 or more first-degree family members 77.2% (CI:65.4-85.0%) of prostate cancer incidence can be attributed to the familial clustering. Our combined estimates show strong familial clustering and a significant effect-modification by age meaning that familial aggregation was associated with earlier disease onset (before age 65). |
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| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T07:24:13Z |
| publishDate | 2011-01-01 |
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| spelling | doaj.art-7786b48fea7b4a3e9885e82fcadd23de2022-12-21T23:11:33ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-01610e2713010.1371/journal.pone.0027130An epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis.Michał KicińskiJaco VangronsveldTim S NawrotStudies on familial aggregation of cancer may suggest an overall contribution of inherited genes or a shared environment in the development of malignant disease. We performed a meta-analysis on familial clustering of prostate cancer. Out of 74 studies reporting data on familial aggregation of prostate cancer in unselected populations retrieved by a Pubmed search and browsing references, 33 independent studies meeting the inclusion criteria were used in the analysis performed with the random effects model. The pooled rate ratio (RR) for first-degree family history, i.e. affected father or brother, is 2.48 (95% confidence interval: 2.25-2.74). The incidence rate for men who have a brother who got prostate cancer increases 3.14 times (CI:2.37-4.15), and for those with affected father 2.35 times (CI:2.02-2.72). The pooled estimate of RR for two or more affected first-degree family members relative to no history in father and in brother is 4.39 (CI:2.61-7.39). First-degree family history appears to increase the incidence rate of prostate cancer more in men under 65 (RR:2.87, CI:2.21-3.74), than in men aged 65 and older (RR:1.92, CI:1.49-2.47), p for interaction = 0.002. The attributable fraction among those having an affected first-degree relative equals to 59.7% (CI:55.6-63.5%) for men at all ages, 65.2% (CI:57.7-71.4%) for men younger than 65 and 47.9% (CI:37.1-56.8%) for men aged 65 or older. For those with a family history in 2 or more first-degree family members 77.2% (CI:65.4-85.0%) of prostate cancer incidence can be attributed to the familial clustering. Our combined estimates show strong familial clustering and a significant effect-modification by age meaning that familial aggregation was associated with earlier disease onset (before age 65).https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22073129/pdf/?tool=EBI |
| spellingShingle | Michał Kiciński Jaco Vangronsveld Tim S Nawrot An epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis. PLoS ONE |
| title | An epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis. |
| title_full | An epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis. |
| title_fullStr | An epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis. |
| title_full_unstemmed | An epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis. |
| title_short | An epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis. |
| title_sort | epidemiological reappraisal of the familial aggregation of prostate cancer a meta analysis |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22073129/pdf/?tool=EBI |
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