Optical monitoring of hemodialysis using noninvasive measurement of uric acid in the dialysate
Abstract The aim of this study was to present a methodology for predicting changes in uric acid concentrations in the blood of chronically hemodialyzed patients based on an optical measurement of the intensity of selected wavelengths in the dialysate. Blood samples were taken from the arterial line...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-08-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-40335-x |
| _version_ | 1797576705853882368 |
|---|---|
| author | Wojciech Żyłka Krystyna Tęcza Krzysztof Szemela Piotr Prach Marta Żyłka Dorota Jakubczyk Maciej Błądziński Agnieszka Gala-Błądzińska Paweł Jakubczyk |
| author_facet | Wojciech Żyłka Krystyna Tęcza Krzysztof Szemela Piotr Prach Marta Żyłka Dorota Jakubczyk Maciej Błądziński Agnieszka Gala-Błądzińska Paweł Jakubczyk |
| author_sort | Wojciech Żyłka |
| collection | DOAJ |
| description | Abstract The aim of this study was to present a methodology for predicting changes in uric acid concentrations in the blood of chronically hemodialyzed patients based on an optical measurement of the intensity of selected wavelengths in the dialysate. Blood samples were taken from the arterial line every 30 min throughout the hemodialysis period, to measure uric acid levels. Simultaneously, optical measurements were made on dialysate flowing from the dialyzer. Uric acid concentration can be measured either directly from the blood or from dialyzer outflow with acceptable error. In addition, both methods reveal any increased dynamics in uric acid concentration in the initial phase of hemodialysis. The wavelength of the light was adjusted for optimal uric acid particle detection. Comparing the uric acid concentration measured in the blood of patients with the intensity of wave absorption in the dialysate, the functional relationship between the uric acid concentration levels was determined. Using the optical method for measuring uric acid concentration in the dialysate, the concentration of uric acid in the blood during hemodialysis can be non-invasively and accurately estimated. This method can be used to assess the adequacy of hemodialysis by computer acquisition of uric acid concentrations determined in on-line dialysate. |
| first_indexed | 2024-03-10T21:55:35Z |
| format | Article |
| id | doaj.art-778735e59dfc4d879dcf37f3ccfd641d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T21:55:35Z |
| publishDate | 2023-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-778735e59dfc4d879dcf37f3ccfd641d2023-11-19T13:07:29ZengNature PortfolioScientific Reports2045-23222023-08-0113111010.1038/s41598-023-40335-xOptical monitoring of hemodialysis using noninvasive measurement of uric acid in the dialysateWojciech Żyłka0Krystyna Tęcza1Krzysztof Szemela2Piotr Prach3Marta Żyłka4Dorota Jakubczyk5Maciej Błądziński6Agnieszka Gala-Błądzińska7Paweł Jakubczyk8Institute of Materials Engineering, College of Natural Sciences, University of RzeszowInstitute of Medical Sciences, Medical College of Rzeszow UniversityInstitute of Physics, College of Natural Sciences, University of RzeszowUniversity of Information Technology and Management in RzeszowThe Faculty of Mechanical Engineering and Aeronautics, Department of Aerospace Engineering, Rzeszow University of TechnologyFaculty of Mathematics and Applied Physics, Rzeszow University of TechnologyInstitute of Medical Sciences, Medical College of Rzeszow UniversityInstitute of Medical Sciences, Medical College of Rzeszow UniversityInstitute of Physics, College of Natural Sciences, University of RzeszowAbstract The aim of this study was to present a methodology for predicting changes in uric acid concentrations in the blood of chronically hemodialyzed patients based on an optical measurement of the intensity of selected wavelengths in the dialysate. Blood samples were taken from the arterial line every 30 min throughout the hemodialysis period, to measure uric acid levels. Simultaneously, optical measurements were made on dialysate flowing from the dialyzer. Uric acid concentration can be measured either directly from the blood or from dialyzer outflow with acceptable error. In addition, both methods reveal any increased dynamics in uric acid concentration in the initial phase of hemodialysis. The wavelength of the light was adjusted for optimal uric acid particle detection. Comparing the uric acid concentration measured in the blood of patients with the intensity of wave absorption in the dialysate, the functional relationship between the uric acid concentration levels was determined. Using the optical method for measuring uric acid concentration in the dialysate, the concentration of uric acid in the blood during hemodialysis can be non-invasively and accurately estimated. This method can be used to assess the adequacy of hemodialysis by computer acquisition of uric acid concentrations determined in on-line dialysate.https://doi.org/10.1038/s41598-023-40335-x |
| spellingShingle | Wojciech Żyłka Krystyna Tęcza Krzysztof Szemela Piotr Prach Marta Żyłka Dorota Jakubczyk Maciej Błądziński Agnieszka Gala-Błądzińska Paweł Jakubczyk Optical monitoring of hemodialysis using noninvasive measurement of uric acid in the dialysate Scientific Reports |
| title | Optical monitoring of hemodialysis using noninvasive measurement of uric acid in the dialysate |
| title_full | Optical monitoring of hemodialysis using noninvasive measurement of uric acid in the dialysate |
| title_fullStr | Optical monitoring of hemodialysis using noninvasive measurement of uric acid in the dialysate |
| title_full_unstemmed | Optical monitoring of hemodialysis using noninvasive measurement of uric acid in the dialysate |
| title_short | Optical monitoring of hemodialysis using noninvasive measurement of uric acid in the dialysate |
| title_sort | optical monitoring of hemodialysis using noninvasive measurement of uric acid in the dialysate |
| url | https://doi.org/10.1038/s41598-023-40335-x |
| work_keys_str_mv | AT wojciechzyłka opticalmonitoringofhemodialysisusingnoninvasivemeasurementofuricacidinthedialysate AT krystynatecza opticalmonitoringofhemodialysisusingnoninvasivemeasurementofuricacidinthedialysate AT krzysztofszemela opticalmonitoringofhemodialysisusingnoninvasivemeasurementofuricacidinthedialysate AT piotrprach opticalmonitoringofhemodialysisusingnoninvasivemeasurementofuricacidinthedialysate AT martazyłka opticalmonitoringofhemodialysisusingnoninvasivemeasurementofuricacidinthedialysate AT dorotajakubczyk opticalmonitoringofhemodialysisusingnoninvasivemeasurementofuricacidinthedialysate AT maciejbładzinski opticalmonitoringofhemodialysisusingnoninvasivemeasurementofuricacidinthedialysate AT agnieszkagalabładzinska opticalmonitoringofhemodialysisusingnoninvasivemeasurementofuricacidinthedialysate AT pawełjakubczyk opticalmonitoringofhemodialysisusingnoninvasivemeasurementofuricacidinthedialysate |