Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems.
PURPOSE:To determine the mechanisms of speech intelligibility impairment due to neurologic impairments, intelligibility decline was modeled as a function of co-occurring changes in the articulatory, resonatory, phonatory, and respiratory subsystems. METHOD:Sixty-six individuals diagnosed with amyotr...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4858181?pdf=render |
| _version_ | 1828849877944107008 |
|---|---|
| author | Panying Rong Yana Yunusova Jun Wang Lorne Zinman Gary L Pattee James D Berry Bridget Perry Jordan R Green |
| author_facet | Panying Rong Yana Yunusova Jun Wang Lorne Zinman Gary L Pattee James D Berry Bridget Perry Jordan R Green |
| author_sort | Panying Rong |
| collection | DOAJ |
| description | PURPOSE:To determine the mechanisms of speech intelligibility impairment due to neurologic impairments, intelligibility decline was modeled as a function of co-occurring changes in the articulatory, resonatory, phonatory, and respiratory subsystems. METHOD:Sixty-six individuals diagnosed with amyotrophic lateral sclerosis (ALS) were studied longitudinally. The disease-related changes in articulatory, resonatory, phonatory, and respiratory subsystems were quantified using multiple instrumental measures, which were subjected to a principal component analysis and mixed effects models to derive a set of speech subsystem predictors. A stepwise approach was used to select the best set of subsystem predictors to model the overall decline in intelligibility. RESULTS:Intelligibility was modeled as a function of five predictors that corresponded to velocities of lip and jaw movements (articulatory), number of syllable repetitions in the alternating motion rate task (articulatory), nasal airflow (resonatory), maximum fundamental frequency (phonatory), and speech pauses (respiratory). The model accounted for 95.6% of the variance in intelligibility, among which the articulatory predictors showed the most substantial independent contribution (57.7%). CONCLUSION:Articulatory impairments characterized by reduced velocities of lip and jaw movements and resonatory impairments characterized by increased nasal airflow served as the subsystem predictors of the longitudinal decline of speech intelligibility in ALS. Declines in maximum performance tasks such as the alternating motion rate preceded declines in intelligibility, thus serving as early predictors of bulbar dysfunction. Following the rapid decline in speech intelligibility, a precipitous decline in maximum performance tasks subsequently occurred. |
| first_indexed | 2024-12-12T23:00:31Z |
| format | Article |
| id | doaj.art-77881a26470a446799749f411901ca5d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T23:00:31Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-77881a26470a446799749f411901ca5d2022-12-22T00:08:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01115e015497110.1371/journal.pone.0154971Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems.Panying RongYana YunusovaJun WangLorne ZinmanGary L PatteeJames D BerryBridget PerryJordan R GreenPURPOSE:To determine the mechanisms of speech intelligibility impairment due to neurologic impairments, intelligibility decline was modeled as a function of co-occurring changes in the articulatory, resonatory, phonatory, and respiratory subsystems. METHOD:Sixty-six individuals diagnosed with amyotrophic lateral sclerosis (ALS) were studied longitudinally. The disease-related changes in articulatory, resonatory, phonatory, and respiratory subsystems were quantified using multiple instrumental measures, which were subjected to a principal component analysis and mixed effects models to derive a set of speech subsystem predictors. A stepwise approach was used to select the best set of subsystem predictors to model the overall decline in intelligibility. RESULTS:Intelligibility was modeled as a function of five predictors that corresponded to velocities of lip and jaw movements (articulatory), number of syllable repetitions in the alternating motion rate task (articulatory), nasal airflow (resonatory), maximum fundamental frequency (phonatory), and speech pauses (respiratory). The model accounted for 95.6% of the variance in intelligibility, among which the articulatory predictors showed the most substantial independent contribution (57.7%). CONCLUSION:Articulatory impairments characterized by reduced velocities of lip and jaw movements and resonatory impairments characterized by increased nasal airflow served as the subsystem predictors of the longitudinal decline of speech intelligibility in ALS. Declines in maximum performance tasks such as the alternating motion rate preceded declines in intelligibility, thus serving as early predictors of bulbar dysfunction. Following the rapid decline in speech intelligibility, a precipitous decline in maximum performance tasks subsequently occurred.http://europepmc.org/articles/PMC4858181?pdf=render |
| spellingShingle | Panying Rong Yana Yunusova Jun Wang Lorne Zinman Gary L Pattee James D Berry Bridget Perry Jordan R Green Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems. PLoS ONE |
| title | Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems. |
| title_full | Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems. |
| title_fullStr | Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems. |
| title_full_unstemmed | Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems. |
| title_short | Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems. |
| title_sort | predicting speech intelligibility decline in amyotrophic lateral sclerosis based on the deterioration of individual speech subsystems |
| url | http://europepmc.org/articles/PMC4858181?pdf=render |
| work_keys_str_mv | AT panyingrong predictingspeechintelligibilitydeclineinamyotrophiclateralsclerosisbasedonthedeteriorationofindividualspeechsubsystems AT yanayunusova predictingspeechintelligibilitydeclineinamyotrophiclateralsclerosisbasedonthedeteriorationofindividualspeechsubsystems AT junwang predictingspeechintelligibilitydeclineinamyotrophiclateralsclerosisbasedonthedeteriorationofindividualspeechsubsystems AT lornezinman predictingspeechintelligibilitydeclineinamyotrophiclateralsclerosisbasedonthedeteriorationofindividualspeechsubsystems AT garylpattee predictingspeechintelligibilitydeclineinamyotrophiclateralsclerosisbasedonthedeteriorationofindividualspeechsubsystems AT jamesdberry predictingspeechintelligibilitydeclineinamyotrophiclateralsclerosisbasedonthedeteriorationofindividualspeechsubsystems AT bridgetperry predictingspeechintelligibilitydeclineinamyotrophiclateralsclerosisbasedonthedeteriorationofindividualspeechsubsystems AT jordanrgreen predictingspeechintelligibilitydeclineinamyotrophiclateralsclerosisbasedonthedeteriorationofindividualspeechsubsystems |