ASSOCIATION BETWEEN INSERTION/DELETION POLYMORPHISM OF THE ANGIOTENSIN-CONVERTING ENZYME GENE AND CORONARY ARTERY DISEASE IN BOSNIAN POPULATION
One of the genes considered as a risk factor for coronary artery disease (CAD) is the angiotensin-converting enzyme (ACE) gene. Many studies have been published regarding the relation between the ACE gene insertion/deletion (I/D) polymorphism and CAD. However, studies have provided controversial res...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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University of Sarajevo, Institute for Genetic Engineering and Biotechnology
2018-03-01
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| Series: | Genetics & Applications |
| Online Access: | http://www.genapp.ba/index.php/genapp/article/view/21 |
| _version_ | 1811246955898077184 |
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| author | Dražena Hadžibeganović Rifet Terzić Amela Jusić Aldijana Avdić |
| author_facet | Dražena Hadžibeganović Rifet Terzić Amela Jusić Aldijana Avdić |
| author_sort | Dražena Hadžibeganović |
| collection | DOAJ |
| description | One of the genes considered as a risk factor for coronary artery disease (CAD) is the angiotensin-converting enzyme (ACE) gene. Many studies have been published regarding the relation between the ACE gene insertion/deletion (I/D) polymorphism and CAD. However, studies have provided controversial results. To explore this further in the population of Bosnia and Herzegovina, we compared the ACE I/D genotypes and alleles distribution between two groups: 100 CAD patients and 100 healthy control subjects. The higher distribution of DD genotype (47.0%) and D allele (65.5%) were found in CAD patients compared to controls (DD 34.0%; D allele 51.0%). Genotype odds ratio, (DD + ID) on the II, was 2.471 (1.252 – 4.876; 95% CI; p < 0.05). This leads to the conclusion that the DD genotype of the ACE I/D polymorphism affects the risk for development of coronary artery disease in Bosnian population. |
| first_indexed | 2024-04-12T15:01:02Z |
| format | Article |
| id | doaj.art-778af2cbb4d648da929ce3110b0e690a |
| institution | Directory Open Access Journal |
| issn | 2566-2937 2566-431X |
| language | English |
| last_indexed | 2024-04-12T15:01:02Z |
| publishDate | 2018-03-01 |
| publisher | University of Sarajevo, Institute for Genetic Engineering and Biotechnology |
| record_format | Article |
| series | Genetics & Applications |
| spelling | doaj.art-778af2cbb4d648da929ce3110b0e690a2022-12-22T03:28:04ZengUniversity of Sarajevo, Institute for Genetic Engineering and BiotechnologyGenetics & Applications2566-29372566-431X2018-03-0112444910.31383/ga.vol1iss2pp44-4921ASSOCIATION BETWEEN INSERTION/DELETION POLYMORPHISM OF THE ANGIOTENSIN-CONVERTING ENZYME GENE AND CORONARY ARTERY DISEASE IN BOSNIAN POPULATIONDražena Hadžibeganović0Rifet Terzić1Amela Jusić2Aldijana Avdić3University of Tuzla, Faculty of Science, Department of Biology, Tuzla, Bosnia and HerzegovinaUniversity of Tuzla, Faculty of Science, Department of Biology, Tuzla, Bosnia and HerzegovinaUniversity of Tuzla, Faculty of Science, Department of Biology, Tuzla, Bosnia and HerzegovinaUniversity of Tuzla, Faculty of Science, Department of Biology, Tuzla, Bosnia and HerzegovinaOne of the genes considered as a risk factor for coronary artery disease (CAD) is the angiotensin-converting enzyme (ACE) gene. Many studies have been published regarding the relation between the ACE gene insertion/deletion (I/D) polymorphism and CAD. However, studies have provided controversial results. To explore this further in the population of Bosnia and Herzegovina, we compared the ACE I/D genotypes and alleles distribution between two groups: 100 CAD patients and 100 healthy control subjects. The higher distribution of DD genotype (47.0%) and D allele (65.5%) were found in CAD patients compared to controls (DD 34.0%; D allele 51.0%). Genotype odds ratio, (DD + ID) on the II, was 2.471 (1.252 – 4.876; 95% CI; p < 0.05). This leads to the conclusion that the DD genotype of the ACE I/D polymorphism affects the risk for development of coronary artery disease in Bosnian population.http://www.genapp.ba/index.php/genapp/article/view/21 |
| spellingShingle | Dražena Hadžibeganović Rifet Terzić Amela Jusić Aldijana Avdić ASSOCIATION BETWEEN INSERTION/DELETION POLYMORPHISM OF THE ANGIOTENSIN-CONVERTING ENZYME GENE AND CORONARY ARTERY DISEASE IN BOSNIAN POPULATION Genetics & Applications |
| title | ASSOCIATION BETWEEN INSERTION/DELETION POLYMORPHISM OF THE ANGIOTENSIN-CONVERTING ENZYME GENE AND CORONARY ARTERY DISEASE IN BOSNIAN POPULATION |
| title_full | ASSOCIATION BETWEEN INSERTION/DELETION POLYMORPHISM OF THE ANGIOTENSIN-CONVERTING ENZYME GENE AND CORONARY ARTERY DISEASE IN BOSNIAN POPULATION |
| title_fullStr | ASSOCIATION BETWEEN INSERTION/DELETION POLYMORPHISM OF THE ANGIOTENSIN-CONVERTING ENZYME GENE AND CORONARY ARTERY DISEASE IN BOSNIAN POPULATION |
| title_full_unstemmed | ASSOCIATION BETWEEN INSERTION/DELETION POLYMORPHISM OF THE ANGIOTENSIN-CONVERTING ENZYME GENE AND CORONARY ARTERY DISEASE IN BOSNIAN POPULATION |
| title_short | ASSOCIATION BETWEEN INSERTION/DELETION POLYMORPHISM OF THE ANGIOTENSIN-CONVERTING ENZYME GENE AND CORONARY ARTERY DISEASE IN BOSNIAN POPULATION |
| title_sort | association between insertion deletion polymorphism of the angiotensin converting enzyme gene and coronary artery disease in bosnian population |
| url | http://www.genapp.ba/index.php/genapp/article/view/21 |
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