Regulation of Proteasome Activity by (Post-)transcriptional Mechanisms
Intracellular protein synthesis, folding, and degradation are tightly controlled processes to ensure proper protein homeostasis. The proteasome is responsible for the degradation of the majority of intracellular proteins, which are often targeted for degradation via polyubiquitination. However, the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fmolb.2019.00048/full |
| _version_ | 1819103827074220032 |
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| author | Suzan Kors Karlijne Geijtenbeek Eric Reits Sabine Schipper-Krom |
| author_facet | Suzan Kors Karlijne Geijtenbeek Eric Reits Sabine Schipper-Krom |
| author_sort | Suzan Kors |
| collection | DOAJ |
| description | Intracellular protein synthesis, folding, and degradation are tightly controlled processes to ensure proper protein homeostasis. The proteasome is responsible for the degradation of the majority of intracellular proteins, which are often targeted for degradation via polyubiquitination. However, the degradation rate of proteins is also affected by the capacity of proteasomes to recognize and degrade these substrate proteins. This capacity is regulated by a variety of proteasome modulations including (1) changes in complex composition, (2) post-translational modifications, and (3) altered transcription of proteasomal subunits and activators. Various diseases are linked to proteasome modulation and altered proteasome function. A better understanding of these modulations may offer new perspectives for therapeutic intervention. Here we present an overview of these three proteasome modulating mechanisms to give better insight into the diversity of proteasomes. |
| first_indexed | 2024-12-22T01:56:38Z |
| format | Article |
| id | doaj.art-77913237ee0249d4814cbe12e81158b0 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-22T01:56:38Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-77913237ee0249d4814cbe12e81158b02022-12-21T18:42:47ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2019-07-01610.3389/fmolb.2019.00048452008Regulation of Proteasome Activity by (Post-)transcriptional MechanismsSuzan KorsKarlijne GeijtenbeekEric ReitsSabine Schipper-KromIntracellular protein synthesis, folding, and degradation are tightly controlled processes to ensure proper protein homeostasis. The proteasome is responsible for the degradation of the majority of intracellular proteins, which are often targeted for degradation via polyubiquitination. However, the degradation rate of proteins is also affected by the capacity of proteasomes to recognize and degrade these substrate proteins. This capacity is regulated by a variety of proteasome modulations including (1) changes in complex composition, (2) post-translational modifications, and (3) altered transcription of proteasomal subunits and activators. Various diseases are linked to proteasome modulation and altered proteasome function. A better understanding of these modulations may offer new perspectives for therapeutic intervention. Here we present an overview of these three proteasome modulating mechanisms to give better insight into the diversity of proteasomes.https://www.frontiersin.org/article/10.3389/fmolb.2019.00048/fullproteasomepost translational modifications20S26Sproteasome complexesproteasome activation/inhibition |
| spellingShingle | Suzan Kors Karlijne Geijtenbeek Eric Reits Sabine Schipper-Krom Regulation of Proteasome Activity by (Post-)transcriptional Mechanisms Frontiers in Molecular Biosciences proteasome post translational modifications 20S 26S proteasome complexes proteasome activation/inhibition |
| title | Regulation of Proteasome Activity by (Post-)transcriptional Mechanisms |
| title_full | Regulation of Proteasome Activity by (Post-)transcriptional Mechanisms |
| title_fullStr | Regulation of Proteasome Activity by (Post-)transcriptional Mechanisms |
| title_full_unstemmed | Regulation of Proteasome Activity by (Post-)transcriptional Mechanisms |
| title_short | Regulation of Proteasome Activity by (Post-)transcriptional Mechanisms |
| title_sort | regulation of proteasome activity by post transcriptional mechanisms |
| topic | proteasome post translational modifications 20S 26S proteasome complexes proteasome activation/inhibition |
| url | https://www.frontiersin.org/article/10.3389/fmolb.2019.00048/full |
| work_keys_str_mv | AT suzankors regulationofproteasomeactivitybyposttranscriptionalmechanisms AT karlijnegeijtenbeek regulationofproteasomeactivitybyposttranscriptionalmechanisms AT ericreits regulationofproteasomeactivitybyposttranscriptionalmechanisms AT sabineschipperkrom regulationofproteasomeactivitybyposttranscriptionalmechanisms |