A Preliminary Study of Personalized Head CT Scan in Pediatric Patients
Objectives: In the present study, we introduced a practical approach to quantify organ-specific radiation doses and investigated whether low-dose head circumference (HC)-based protocols for non-enhanced head computed tomography (CT) could reduce organs-specific radiation dose in pediatric patients w...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-03-01
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| Series: | Dose-Response |
| Online Access: | https://doi.org/10.1177/1559325820985660 |
| _version_ | 1818827399477854208 |
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| author | Bian Bingyang Wang Gang Shao Zhiqing Nan Li BoXu Zhou ShuJia Xu Dan Li |
| author_facet | Bian Bingyang Wang Gang Shao Zhiqing Nan Li BoXu Zhou ShuJia Xu Dan Li |
| author_sort | Bian Bingyang |
| collection | DOAJ |
| description | Objectives: In the present study, we introduced a practical approach to quantify organ-specific radiation doses and investigated whether low-dose head circumference (HC)-based protocols for non-enhanced head computed tomography (CT) could reduce organs-specific radiation dose in pediatric patients while maintaining high image quality. Methods: A total of 83 pediatric patients were prospectively recruited. Without limits to the HC, 15 patients were selected as a convention group (CON group) and underwent non-enhanced head CT scan with standard-dose protocols (tube current-time products of 250mAs). Low-dose group (LD group), including remaining 68 pediatrics were divided into 3 subgroups based on the HC: 54.1-57.0 cm for LD 200mAs group (HC-based protocols of 200mAs), 51.1-54.0 cm for LD 150mAs group (HC-based protocols of 150mAs), 48.1-51.0 cm for LD 100mAs group (HC-based protocols of 100mAs). Subjective and objective image quality was evaluated and measured by 2 experienced radiologists. Radimetrics was used to calculate organs-specific radiation dose, including the brain, eye lenses, and salivary glands. Results: In CON 250mAs group, radiation doses in the brain and salivary glands were conversely correlated with HC, and pediatric patients with smaller HC received higher organs-specific radiation dose. Reducing tube current-time product from 250 to 100mAs could significantly reduce the organ-specific radiation dose. The subjective image quality score ≥ 3.0 is acceptable for diagnosis purposes. The signal to noise ratio (SNR) and the contrast to noise ratio (CNR) of bilateral thalamus and centrum semiovale in 3 LD subgroups were not statistically different compared with the CON group. Conclusion: Our research indicated that low-dose HC-based protocols of non-enhanced head CT scan can evidently reduce the organ-specific radiation doses, while maintaining high image quality. HC can serve as a vital tool to guide personalized low-dose head CT scan for pediatric patients. |
| first_indexed | 2024-12-19T00:42:56Z |
| format | Article |
| id | doaj.art-779202b68f1c4962bc6411fcfffbad71 |
| institution | Directory Open Access Journal |
| issn | 1559-3258 |
| language | English |
| last_indexed | 2024-12-19T00:42:56Z |
| publishDate | 2021-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Dose-Response |
| spelling | doaj.art-779202b68f1c4962bc6411fcfffbad712022-12-21T20:44:26ZengSAGE PublishingDose-Response1559-32582021-03-011910.1177/1559325820985660A Preliminary Study of Personalized Head CT Scan in Pediatric PatientsBian Bingyang0Wang Gang1Shao Zhiqing2Nan Li3BoXu Zhou4ShuJia Xu5Dan Li6 , Changchun, China , Changchun, China , Changchun, China , Changchun, China , Changchun, China , Changchun, China , Changchun, ChinaObjectives: In the present study, we introduced a practical approach to quantify organ-specific radiation doses and investigated whether low-dose head circumference (HC)-based protocols for non-enhanced head computed tomography (CT) could reduce organs-specific radiation dose in pediatric patients while maintaining high image quality. Methods: A total of 83 pediatric patients were prospectively recruited. Without limits to the HC, 15 patients were selected as a convention group (CON group) and underwent non-enhanced head CT scan with standard-dose protocols (tube current-time products of 250mAs). Low-dose group (LD group), including remaining 68 pediatrics were divided into 3 subgroups based on the HC: 54.1-57.0 cm for LD 200mAs group (HC-based protocols of 200mAs), 51.1-54.0 cm for LD 150mAs group (HC-based protocols of 150mAs), 48.1-51.0 cm for LD 100mAs group (HC-based protocols of 100mAs). Subjective and objective image quality was evaluated and measured by 2 experienced radiologists. Radimetrics was used to calculate organs-specific radiation dose, including the brain, eye lenses, and salivary glands. Results: In CON 250mAs group, radiation doses in the brain and salivary glands were conversely correlated with HC, and pediatric patients with smaller HC received higher organs-specific radiation dose. Reducing tube current-time product from 250 to 100mAs could significantly reduce the organ-specific radiation dose. The subjective image quality score ≥ 3.0 is acceptable for diagnosis purposes. The signal to noise ratio (SNR) and the contrast to noise ratio (CNR) of bilateral thalamus and centrum semiovale in 3 LD subgroups were not statistically different compared with the CON group. Conclusion: Our research indicated that low-dose HC-based protocols of non-enhanced head CT scan can evidently reduce the organ-specific radiation doses, while maintaining high image quality. HC can serve as a vital tool to guide personalized low-dose head CT scan for pediatric patients.https://doi.org/10.1177/1559325820985660 |
| spellingShingle | Bian Bingyang Wang Gang Shao Zhiqing Nan Li BoXu Zhou ShuJia Xu Dan Li A Preliminary Study of Personalized Head CT Scan in Pediatric Patients Dose-Response |
| title | A Preliminary Study of Personalized Head CT Scan in Pediatric Patients |
| title_full | A Preliminary Study of Personalized Head CT Scan in Pediatric Patients |
| title_fullStr | A Preliminary Study of Personalized Head CT Scan in Pediatric Patients |
| title_full_unstemmed | A Preliminary Study of Personalized Head CT Scan in Pediatric Patients |
| title_short | A Preliminary Study of Personalized Head CT Scan in Pediatric Patients |
| title_sort | preliminary study of personalized head ct scan in pediatric patients |
| url | https://doi.org/10.1177/1559325820985660 |
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