Cell Division Cycle Associated Genes as Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma
With high mortality and poor prognosis, hepatocellular carcinoma (LIHC) has become the fourth leading cause of cancer-related deaths worldwide. Most of the LIHC patients missed the best treatment period because of the untimely diagnosis. For others, even if they are temporarily cured, they have to f...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.657161/full |
| _version_ | 1819139985490575360 |
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| author | Shan-Shan Jiang Sheng-Jie Ke Zun-Li Ke Juan Li Xiang Li Xing-Wei Xie |
| author_facet | Shan-Shan Jiang Sheng-Jie Ke Zun-Li Ke Juan Li Xiang Li Xing-Wei Xie |
| author_sort | Shan-Shan Jiang |
| collection | DOAJ |
| description | With high mortality and poor prognosis, hepatocellular carcinoma (LIHC) has become the fourth leading cause of cancer-related deaths worldwide. Most of the LIHC patients missed the best treatment period because of the untimely diagnosis. For others, even if they are temporarily cured, they have to face a very low prognostic survival rate and a very high risk of recurrence. Based on the characteristics of abnormal proliferation and uncontrolled growth of tumor cells. Cell Division Cycle Associated (CDCA) family genes, which are responsible for regulating the cell cycle and proliferation, were selected as our research object to explore the mechanism of hepatocarcinogenesis. To this end, we investigated the expression profiles of CDCA family genes in LIHC and corresponding normal tissues, and the effect of CDCAs expression on the survival of prognosis and immune cell infiltration through bioinformatics analysis methods and the publicly accessible online databases. In addition, we also analyzed the expression correlation of CDCAs and screened the neighboring genes related to functional CDCAs. The results revealed that the expression levels of CDCA1/3/5/8 were significantly increased in LIHC, regardless of stage, sex, race, drinking behavior, and other clinical factors. CDCAs expression was significantly correlated with poor prognosis and was positively correlated with the infiltration of dendritic cells, B cells, and macrophages. We also found that the most relevant neighboring genes to CDCAs in LIHC were SGO2, NDC80, BIRC5, INCENP, and PLOD1. In general, our work suggests that CDCA1/3/5/8 has the potential to be a diagnostic gene in hepatocarcinogenesis and prognostic biomarkers for LIHC patients. |
| first_indexed | 2024-12-22T11:31:22Z |
| format | Article |
| id | doaj.art-7792c46d516a469586086bb24bcef3f0 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-22T11:31:22Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-7792c46d516a469586086bb24bcef3f02022-12-21T18:27:35ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-03-01810.3389/fmolb.2021.657161657161Cell Division Cycle Associated Genes as Diagnostic and Prognostic Biomarkers in Hepatocellular CarcinomaShan-Shan Jiang0Sheng-Jie Ke1Zun-Li Ke2Juan Li3Xiang Li4Xing-Wei Xie5Key Laboratory of Forensic Toxicology of Herbal Medicines, Guizhou Education Department, School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, ChinaFaculty of Basic Medicine, Zhengzhou Shuqing Medical College, Henan, ChinaKey Laboratory of Forensic Toxicology of Herbal Medicines, Guizhou Education Department, School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, ChinaKey Laboratory of Forensic Toxicology of Herbal Medicines, Guizhou Education Department, School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, ChinaCollege of Plant Protection, Henan Agricultural University, Zhengzhou, ChinaKey Laboratory of Forensic Toxicology of Herbal Medicines, Guizhou Education Department, School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, ChinaWith high mortality and poor prognosis, hepatocellular carcinoma (LIHC) has become the fourth leading cause of cancer-related deaths worldwide. Most of the LIHC patients missed the best treatment period because of the untimely diagnosis. For others, even if they are temporarily cured, they have to face a very low prognostic survival rate and a very high risk of recurrence. Based on the characteristics of abnormal proliferation and uncontrolled growth of tumor cells. Cell Division Cycle Associated (CDCA) family genes, which are responsible for regulating the cell cycle and proliferation, were selected as our research object to explore the mechanism of hepatocarcinogenesis. To this end, we investigated the expression profiles of CDCA family genes in LIHC and corresponding normal tissues, and the effect of CDCAs expression on the survival of prognosis and immune cell infiltration through bioinformatics analysis methods and the publicly accessible online databases. In addition, we also analyzed the expression correlation of CDCAs and screened the neighboring genes related to functional CDCAs. The results revealed that the expression levels of CDCA1/3/5/8 were significantly increased in LIHC, regardless of stage, sex, race, drinking behavior, and other clinical factors. CDCAs expression was significantly correlated with poor prognosis and was positively correlated with the infiltration of dendritic cells, B cells, and macrophages. We also found that the most relevant neighboring genes to CDCAs in LIHC were SGO2, NDC80, BIRC5, INCENP, and PLOD1. In general, our work suggests that CDCA1/3/5/8 has the potential to be a diagnostic gene in hepatocarcinogenesis and prognostic biomarkers for LIHC patients.https://www.frontiersin.org/articles/10.3389/fmolb.2021.657161/fullCDCAhepatocellular carcinomabiomarkersprognosistumor immunity |
| spellingShingle | Shan-Shan Jiang Sheng-Jie Ke Zun-Li Ke Juan Li Xiang Li Xing-Wei Xie Cell Division Cycle Associated Genes as Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma Frontiers in Molecular Biosciences CDCA hepatocellular carcinoma biomarkers prognosis tumor immunity |
| title | Cell Division Cycle Associated Genes as Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma |
| title_full | Cell Division Cycle Associated Genes as Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma |
| title_fullStr | Cell Division Cycle Associated Genes as Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma |
| title_full_unstemmed | Cell Division Cycle Associated Genes as Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma |
| title_short | Cell Division Cycle Associated Genes as Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma |
| title_sort | cell division cycle associated genes as diagnostic and prognostic biomarkers in hepatocellular carcinoma |
| topic | CDCA hepatocellular carcinoma biomarkers prognosis tumor immunity |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.657161/full |
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