Starch/PCL composite nanofibers by co-axial electrospinning technique for biomedical applications
Abstract Background In this study, starch and polycaprolactone (PCL), composite nanofibers were fabricated by co-axial needle electrospinning technique. Processing parameters such as polymer concentration, flow rate and voltage had a marked influence on the composite fiber diameter. Fourier transfor...
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| Format: | Article |
| Language: | English |
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BMC
2017-03-01
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| Series: | BioMedical Engineering OnLine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12938-017-0334-y |
| _version_ | 1818537061741756416 |
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| author | B. Komur F. Bayrak N. Ekren M. S. Eroglu F. N. Oktar Z. A. Sinirlioglu S. Yucel O. Guler O. Gunduz |
| author_facet | B. Komur F. Bayrak N. Ekren M. S. Eroglu F. N. Oktar Z. A. Sinirlioglu S. Yucel O. Guler O. Gunduz |
| author_sort | B. Komur |
| collection | DOAJ |
| description | Abstract Background In this study, starch and polycaprolactone (PCL), composite nanofibers were fabricated by co-axial needle electrospinning technique. Processing parameters such as polymer concentration, flow rate and voltage had a marked influence on the composite fiber diameter. Fourier transform infrared spectroscopy, scanning electron microscopy (SEM), mechanical and physical properties (such as density, viscosity and electrical conductivity) of the composite fibres were evaluated. Moreover, a cell culture test was performed in order to determine their cytotoxicity for wound dressing application. Results The effect of starch ratio in the solution on the properties and morphological structure of the fibers produced was presented. With lower starch concentration values, the fibers have greater ultimate tensile strength characteristic (mostly 4 and 5 wt%). According to SEM results, it can be figured out that the nanofibers fabricated have good spinnability and morphology. The mean diameter of the fibers is about 150 nm. According to results of cell culture study, the finding can be determined that the increase of starch in the fiber also increases the cell viability. Conclusions Composite nanofibers of starch/PCL have been prepared using a co-axial needle electrospinning technique. PCL was successfully encapsulated within starch. Fiber formation was observed for different ratio of starch. With several test, analysis and measurement performed, some important parameters such as quality and effectuality of each fiber obtained for wound dressing applications were discussed in detail. |
| first_indexed | 2024-12-11T18:45:54Z |
| format | Article |
| id | doaj.art-779320a327354625ad02cf02a3c088a3 |
| institution | Directory Open Access Journal |
| issn | 1475-925X |
| language | English |
| last_indexed | 2024-12-11T18:45:54Z |
| publishDate | 2017-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BioMedical Engineering OnLine |
| spelling | doaj.art-779320a327354625ad02cf02a3c088a32022-12-22T00:54:27ZengBMCBioMedical Engineering OnLine1475-925X2017-03-0116111310.1186/s12938-017-0334-yStarch/PCL composite nanofibers by co-axial electrospinning technique for biomedical applicationsB. Komur0F. Bayrak1N. Ekren2M. S. Eroglu3F. N. Oktar4Z. A. Sinirlioglu5S. Yucel6O. Guler7O. Gunduz8Kanuni Sultan Suleyman Training and Research HospitalAdvanced Nanomaterials Research Laboratory, Department of Metallurgical and Materials Engineering, Marmara UniversityAdvanced Nanomaterials Research Laboratory, Department of Metallurgical and Materials Engineering, Marmara UniversityDepartment of Chemical Engineering, Faculty of Engineering, Marmara UniversityAdvanced Nanomaterials Research Laboratory, Department of Metallurgical and Materials Engineering, Marmara UniversityAysin Biotechnology Limited CompanyDepartment of Bioengineering, Faculty of Chemical and Metallurgical Engineering, Yıldız Technical University, Davutpasa CampusDepartment of Orthopedics and Traumatology, Faculty of Medicine, Istanbul Medipol UniversityAdvanced Nanomaterials Research Laboratory, Department of Metallurgical and Materials Engineering, Marmara UniversityAbstract Background In this study, starch and polycaprolactone (PCL), composite nanofibers were fabricated by co-axial needle electrospinning technique. Processing parameters such as polymer concentration, flow rate and voltage had a marked influence on the composite fiber diameter. Fourier transform infrared spectroscopy, scanning electron microscopy (SEM), mechanical and physical properties (such as density, viscosity and electrical conductivity) of the composite fibres were evaluated. Moreover, a cell culture test was performed in order to determine their cytotoxicity for wound dressing application. Results The effect of starch ratio in the solution on the properties and morphological structure of the fibers produced was presented. With lower starch concentration values, the fibers have greater ultimate tensile strength characteristic (mostly 4 and 5 wt%). According to SEM results, it can be figured out that the nanofibers fabricated have good spinnability and morphology. The mean diameter of the fibers is about 150 nm. According to results of cell culture study, the finding can be determined that the increase of starch in the fiber also increases the cell viability. Conclusions Composite nanofibers of starch/PCL have been prepared using a co-axial needle electrospinning technique. PCL was successfully encapsulated within starch. Fiber formation was observed for different ratio of starch. With several test, analysis and measurement performed, some important parameters such as quality and effectuality of each fiber obtained for wound dressing applications were discussed in detail.http://link.springer.com/article/10.1186/s12938-017-0334-yNanofiberElectrospinningStarchPCLWound dressing |
| spellingShingle | B. Komur F. Bayrak N. Ekren M. S. Eroglu F. N. Oktar Z. A. Sinirlioglu S. Yucel O. Guler O. Gunduz Starch/PCL composite nanofibers by co-axial electrospinning technique for biomedical applications BioMedical Engineering OnLine Nanofiber Electrospinning Starch PCL Wound dressing |
| title | Starch/PCL composite nanofibers by co-axial electrospinning technique for biomedical applications |
| title_full | Starch/PCL composite nanofibers by co-axial electrospinning technique for biomedical applications |
| title_fullStr | Starch/PCL composite nanofibers by co-axial electrospinning technique for biomedical applications |
| title_full_unstemmed | Starch/PCL composite nanofibers by co-axial electrospinning technique for biomedical applications |
| title_short | Starch/PCL composite nanofibers by co-axial electrospinning technique for biomedical applications |
| title_sort | starch pcl composite nanofibers by co axial electrospinning technique for biomedical applications |
| topic | Nanofiber Electrospinning Starch PCL Wound dressing |
| url | http://link.springer.com/article/10.1186/s12938-017-0334-y |
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