Quitting smoking after a cancer diagnosis is associated with high-risk neutrophil-to-lymphocyte ratio among tobacco use-related cancer survivors
Abstract Quitting smoking could potentially minimize the risk of a high neutrophil-to-lymphocyte ratio (NLR) among tobacco use-related (TUR) cancer survivors. A total of 1263 TUR cancer survivors aged 20 to 85 years old were investigated using data from the National Health and Nutritional Examinatio...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-27624-1 |
| _version_ | 1797864698510573568 |
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| author | You Lu Katherine Kwong James Wells Andrea Edwards Zhong Chen Tung-Sung Tseng Kun Zhang |
| author_facet | You Lu Katherine Kwong James Wells Andrea Edwards Zhong Chen Tung-Sung Tseng Kun Zhang |
| author_sort | You Lu |
| collection | DOAJ |
| description | Abstract Quitting smoking could potentially minimize the risk of a high neutrophil-to-lymphocyte ratio (NLR) among tobacco use-related (TUR) cancer survivors. A total of 1263 TUR cancer survivors aged 20 to 85 years old were investigated using data from the National Health and Nutritional Examination Survey 1999–2018. The primary outcome was the NLR, which was defined as having two levels: high-risk (≥ 3) and low-risk (< 3). The association between smoking cessation time and a high-risk NLR level was analyzed using weighted logistic regression models. Overall, the current smoking rate of TUR cancer survivors was found to be 21.7%. Older age (75 years above), gender and respiratory-related cancers are covariables associated with high risk of NLR levels for individual who identified as Non-Hispanic White (NHW). Non-Hispanic Black (NHB) (n = 27) who quit smoking after a cancer diagnosis were associated with the highest risk of a high NLR (OR 4.83, 95% CI 1.40–16.61, p = 0.01) compared to NHB nonsmokers (n = 139). These findings suggest that the risk of a high NLR level is strongly associated with the time of smoking cessation in NHB TUR cancer survivors. As a result, NHB TUR cancer survivors should quit smoking as soon as possible because the benefits of quitting smoking were observed over the 5 year period following smoking cessation. |
| first_indexed | 2024-04-09T22:56:12Z |
| format | Article |
| id | doaj.art-77957bdc612143be87cb77f252456afa |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T22:56:12Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-77957bdc612143be87cb77f252456afa2023-03-22T11:14:07ZengNature PortfolioScientific Reports2045-23222023-02-0113111110.1038/s41598-023-27624-1Quitting smoking after a cancer diagnosis is associated with high-risk neutrophil-to-lymphocyte ratio among tobacco use-related cancer survivorsYou Lu0Katherine Kwong1James Wells2Andrea Edwards3Zhong Chen4Tung-Sung Tseng5Kun Zhang6Department of Physics and Computer Science, Xavier University of LouisianaDepartment of Human Development, Connecticut CollegeDepartment of Physiology, Tulane UniversityDepartment of Physics and Computer Science, Xavier University of LouisianaDepartment of Physics and Computer Science, Xavier University of LouisianaBehavioral and Community Health Science, School of Public Health, Louisiana State University Health Science CenterDepartment of Physics and Computer Science, Xavier University of LouisianaAbstract Quitting smoking could potentially minimize the risk of a high neutrophil-to-lymphocyte ratio (NLR) among tobacco use-related (TUR) cancer survivors. A total of 1263 TUR cancer survivors aged 20 to 85 years old were investigated using data from the National Health and Nutritional Examination Survey 1999–2018. The primary outcome was the NLR, which was defined as having two levels: high-risk (≥ 3) and low-risk (< 3). The association between smoking cessation time and a high-risk NLR level was analyzed using weighted logistic regression models. Overall, the current smoking rate of TUR cancer survivors was found to be 21.7%. Older age (75 years above), gender and respiratory-related cancers are covariables associated with high risk of NLR levels for individual who identified as Non-Hispanic White (NHW). Non-Hispanic Black (NHB) (n = 27) who quit smoking after a cancer diagnosis were associated with the highest risk of a high NLR (OR 4.83, 95% CI 1.40–16.61, p = 0.01) compared to NHB nonsmokers (n = 139). These findings suggest that the risk of a high NLR level is strongly associated with the time of smoking cessation in NHB TUR cancer survivors. As a result, NHB TUR cancer survivors should quit smoking as soon as possible because the benefits of quitting smoking were observed over the 5 year period following smoking cessation.https://doi.org/10.1038/s41598-023-27624-1 |
| spellingShingle | You Lu Katherine Kwong James Wells Andrea Edwards Zhong Chen Tung-Sung Tseng Kun Zhang Quitting smoking after a cancer diagnosis is associated with high-risk neutrophil-to-lymphocyte ratio among tobacco use-related cancer survivors Scientific Reports |
| title | Quitting smoking after a cancer diagnosis is associated with high-risk neutrophil-to-lymphocyte ratio among tobacco use-related cancer survivors |
| title_full | Quitting smoking after a cancer diagnosis is associated with high-risk neutrophil-to-lymphocyte ratio among tobacco use-related cancer survivors |
| title_fullStr | Quitting smoking after a cancer diagnosis is associated with high-risk neutrophil-to-lymphocyte ratio among tobacco use-related cancer survivors |
| title_full_unstemmed | Quitting smoking after a cancer diagnosis is associated with high-risk neutrophil-to-lymphocyte ratio among tobacco use-related cancer survivors |
| title_short | Quitting smoking after a cancer diagnosis is associated with high-risk neutrophil-to-lymphocyte ratio among tobacco use-related cancer survivors |
| title_sort | quitting smoking after a cancer diagnosis is associated with high risk neutrophil to lymphocyte ratio among tobacco use related cancer survivors |
| url | https://doi.org/10.1038/s41598-023-27624-1 |
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