A Novel and Easy-to-Promote Prognostic Model for Patients With Uveal Melanoma
PurposeTo establish an easy and widely applicable prognostic prediction model for uveal melanoma (UM) based on a Chinese population.Patients and MethodsA total of 295 consecutive cases treated at the Eye & ENT Hospital of Fudan University were included as the primary cohort, and 256 cases we...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.879394/full |
| _version_ | 1811340424887926784 |
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| author | Han Yue Han Yue Binbin Xu Binbin Xu Jian Gao Yingwen Bi Kang Xue Kang Xue Jie Guo Jie Guo Rui Zhang Rui Zhang Hui Ren Hui Ren Yifei Yuan Yifei Yuan Jiang Qian Jiang Qian |
| author_facet | Han Yue Han Yue Binbin Xu Binbin Xu Jian Gao Yingwen Bi Kang Xue Kang Xue Jie Guo Jie Guo Rui Zhang Rui Zhang Hui Ren Hui Ren Yifei Yuan Yifei Yuan Jiang Qian Jiang Qian |
| author_sort | Han Yue |
| collection | DOAJ |
| description | PurposeTo establish an easy and widely applicable prognostic prediction model for uveal melanoma (UM) based on a Chinese population.Patients and MethodsA total of 295 consecutive cases treated at the Eye & ENT Hospital of Fudan University were included as the primary cohort, and 256 cases were included in the validation cohorts from two external Caucasian databases. Clinicopathological data were collected retrospectively, and nomogram models were formulated based on multivariable analysis. The concordance index (C-index), AUC (area under the Receiver Operating Characteristic, ROC curve), and Brier score were calculated and compared.ResultsBased on the training cohort, a nomogram model was established with five relevant variables: age, tumor size, ciliary body involvement, non-spindle cell type and extra-scleral extension. The C-index was 0.737, the 3- and 5-year AUCs were 0.767 and 0.742, and the Brier scores for 3- and 5-year survival were 0.082 and 0.129, respectively, which showed superior prediction compared to that of the Tumor, Node and Metastasis staging system. The model also displayed good discrimination and calibration in the external validation cohorts. By risk stratification, patients could be divided into low- and high-risk groups, and the overall survival curves displayed significant differences in the training and validation cohorts.ConclusionOur nomogram model was simple and accurate at predicting the overall survival of patients with UM. It was established based on Asian patients and proved suitable for Caucasian patients; thus, it has a wide range of potential applications, especially for patients living in less medically developed countries and regions. |
| first_indexed | 2024-04-13T18:41:43Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T18:41:43Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-779751549f6b4739933cabb5f4e7882e2022-12-22T02:34:42ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-06-011210.3389/fonc.2022.879394879394A Novel and Easy-to-Promote Prognostic Model for Patients With Uveal MelanomaHan Yue0Han Yue1Binbin Xu2Binbin Xu3Jian Gao4Yingwen Bi5Kang Xue6Kang Xue7Jie Guo8Jie Guo9Rui Zhang10Rui Zhang11Hui Ren12Hui Ren13Yifei Yuan14Yifei Yuan15Jiang Qian16Jiang Qian17Department of Ophthalmology, Eye & Ear, Nose, and Throat (ENT) Hospital of Fudan University, Shanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Eye & Ear, Nose, and Throat (ENT) Hospital of Fudan University, Shanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, ChinaCenter of Clinical Epidemiology and Evidence-based Medicine, Fudan University, Shanghai, ChinaDepartment of Pathology, Eye & Ear, Nose, and Throat (ENT) Hospital of Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Eye & Ear, Nose, and Throat (ENT) Hospital of Fudan University, Shanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Eye & Ear, Nose, and Throat (ENT) Hospital of Fudan University, Shanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Eye & Ear, Nose, and Throat (ENT) Hospital of Fudan University, Shanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Eye & Ear, Nose, and Throat (ENT) Hospital of Fudan University, Shanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Eye & Ear, Nose, and Throat (ENT) Hospital of Fudan University, Shanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Eye & Ear, Nose, and Throat (ENT) Hospital of Fudan University, Shanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, ChinaPurposeTo establish an easy and widely applicable prognostic prediction model for uveal melanoma (UM) based on a Chinese population.Patients and MethodsA total of 295 consecutive cases treated at the Eye & ENT Hospital of Fudan University were included as the primary cohort, and 256 cases were included in the validation cohorts from two external Caucasian databases. Clinicopathological data were collected retrospectively, and nomogram models were formulated based on multivariable analysis. The concordance index (C-index), AUC (area under the Receiver Operating Characteristic, ROC curve), and Brier score were calculated and compared.ResultsBased on the training cohort, a nomogram model was established with five relevant variables: age, tumor size, ciliary body involvement, non-spindle cell type and extra-scleral extension. The C-index was 0.737, the 3- and 5-year AUCs were 0.767 and 0.742, and the Brier scores for 3- and 5-year survival were 0.082 and 0.129, respectively, which showed superior prediction compared to that of the Tumor, Node and Metastasis staging system. The model also displayed good discrimination and calibration in the external validation cohorts. By risk stratification, patients could be divided into low- and high-risk groups, and the overall survival curves displayed significant differences in the training and validation cohorts.ConclusionOur nomogram model was simple and accurate at predicting the overall survival of patients with UM. It was established based on Asian patients and proved suitable for Caucasian patients; thus, it has a wide range of potential applications, especially for patients living in less medically developed countries and regions.https://www.frontiersin.org/articles/10.3389/fonc.2022.879394/fulluveal melanoma (UM)prognostic modelnomogramsurvival probabilitiesexternal validation |
| spellingShingle | Han Yue Han Yue Binbin Xu Binbin Xu Jian Gao Yingwen Bi Kang Xue Kang Xue Jie Guo Jie Guo Rui Zhang Rui Zhang Hui Ren Hui Ren Yifei Yuan Yifei Yuan Jiang Qian Jiang Qian A Novel and Easy-to-Promote Prognostic Model for Patients With Uveal Melanoma Frontiers in Oncology uveal melanoma (UM) prognostic model nomogram survival probabilities external validation |
| title | A Novel and Easy-to-Promote Prognostic Model for Patients With Uveal Melanoma |
| title_full | A Novel and Easy-to-Promote Prognostic Model for Patients With Uveal Melanoma |
| title_fullStr | A Novel and Easy-to-Promote Prognostic Model for Patients With Uveal Melanoma |
| title_full_unstemmed | A Novel and Easy-to-Promote Prognostic Model for Patients With Uveal Melanoma |
| title_short | A Novel and Easy-to-Promote Prognostic Model for Patients With Uveal Melanoma |
| title_sort | novel and easy to promote prognostic model for patients with uveal melanoma |
| topic | uveal melanoma (UM) prognostic model nomogram survival probabilities external validation |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.879394/full |
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