Common neural mechanisms underlying reversal learning by reward and punishment.
Impairments in flexible goal-directed decisions, often examined by reversal learning, are associated with behavioral abnormalities characterized by impulsiveness and disinhibition. Although the lateral orbital frontal cortex (OFC) has been consistently implicated in reversal learning, it is still un...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3859585?pdf=render |
| _version_ | 1818021676501172224 |
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| author | Gui Xue Feng Xue Vita Droutman Zhong-Lin Lu Antoine Bechara Stephen Read |
| author_facet | Gui Xue Feng Xue Vita Droutman Zhong-Lin Lu Antoine Bechara Stephen Read |
| author_sort | Gui Xue |
| collection | DOAJ |
| description | Impairments in flexible goal-directed decisions, often examined by reversal learning, are associated with behavioral abnormalities characterized by impulsiveness and disinhibition. Although the lateral orbital frontal cortex (OFC) has been consistently implicated in reversal learning, it is still unclear whether this region is involved in negative feedback processing, behavioral control, or both, and whether reward and punishment might have different effects on lateral OFC involvement. Using a relatively large sample (N = 47), and a categorical learning task with either monetary reward or moderate electric shock as feedback, we found overlapping activations in the right lateral OFC (and adjacent insula) for reward and punishment reversal learning when comparing correct reversal trials with correct acquisition trials, whereas we found overlapping activations in the right dorsolateral prefrontal cortex (DLPFC) when negative feedback signaled contingency change. The right lateral OFC and DLPFC also showed greater sensitivity to punishment than did their left homologues, indicating an asymmetry in how punishment is processed. We propose that the right lateral OFC and anterior insula are important for transforming affective feedback to behavioral adjustment, whereas the right DLPFC is involved in higher level attention control. These results provide insight into the neural mechanisms of reversal learning and behavioral flexibility, which can be leveraged to understand risky behaviors among vulnerable populations. |
| first_indexed | 2024-04-14T08:21:00Z |
| format | Article |
| id | doaj.art-779763eb626746a98414cdf00d5e4b1b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-14T08:21:00Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-779763eb626746a98414cdf00d5e4b1b2022-12-22T02:04:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01812e8216910.1371/journal.pone.0082169Common neural mechanisms underlying reversal learning by reward and punishment.Gui XueFeng XueVita DroutmanZhong-Lin LuAntoine BecharaStephen ReadImpairments in flexible goal-directed decisions, often examined by reversal learning, are associated with behavioral abnormalities characterized by impulsiveness and disinhibition. Although the lateral orbital frontal cortex (OFC) has been consistently implicated in reversal learning, it is still unclear whether this region is involved in negative feedback processing, behavioral control, or both, and whether reward and punishment might have different effects on lateral OFC involvement. Using a relatively large sample (N = 47), and a categorical learning task with either monetary reward or moderate electric shock as feedback, we found overlapping activations in the right lateral OFC (and adjacent insula) for reward and punishment reversal learning when comparing correct reversal trials with correct acquisition trials, whereas we found overlapping activations in the right dorsolateral prefrontal cortex (DLPFC) when negative feedback signaled contingency change. The right lateral OFC and DLPFC also showed greater sensitivity to punishment than did their left homologues, indicating an asymmetry in how punishment is processed. We propose that the right lateral OFC and anterior insula are important for transforming affective feedback to behavioral adjustment, whereas the right DLPFC is involved in higher level attention control. These results provide insight into the neural mechanisms of reversal learning and behavioral flexibility, which can be leveraged to understand risky behaviors among vulnerable populations.http://europepmc.org/articles/PMC3859585?pdf=render |
| spellingShingle | Gui Xue Feng Xue Vita Droutman Zhong-Lin Lu Antoine Bechara Stephen Read Common neural mechanisms underlying reversal learning by reward and punishment. PLoS ONE |
| title | Common neural mechanisms underlying reversal learning by reward and punishment. |
| title_full | Common neural mechanisms underlying reversal learning by reward and punishment. |
| title_fullStr | Common neural mechanisms underlying reversal learning by reward and punishment. |
| title_full_unstemmed | Common neural mechanisms underlying reversal learning by reward and punishment. |
| title_short | Common neural mechanisms underlying reversal learning by reward and punishment. |
| title_sort | common neural mechanisms underlying reversal learning by reward and punishment |
| url | http://europepmc.org/articles/PMC3859585?pdf=render |
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