The impact of ACE2 genetic polymorphisms (rs2106809 and rs2074192) on gender susceptibility to COVID-19 infection and recovery: A systematic review
Background: Epidemiological studies revealed there is a difference in susceptibility to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) because of differences in gender with age and males being more inflicted. There is a clear indication that deaths caused by coronavirus...
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| Format: | Article |
| Language: | English |
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College of Medicine, Al-Nahrain University
2021-09-01
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| Series: | Baghdad Journal of Biochemistry and Applied Biological Sciences |
| Subjects: | |
| Online Access: | https://bjbabs.org/index.php/bjbabs/article/view/53/43 |
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| author | Ahmed A. Suleiman Tamadher A. Rafaa Ali M. Alrawi Mustafa F. Dawood |
| author_facet | Ahmed A. Suleiman Tamadher A. Rafaa Ali M. Alrawi Mustafa F. Dawood |
| author_sort | Ahmed A. Suleiman |
| collection | DOAJ |
| description | Background: Epidemiological studies revealed there is a difference in susceptibility to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) because of differences in gender with age and males being more inflicted. There is a clear indication that deaths caused by coronavirus disease 2019 (COVID-19) in males appeared at a higher rate than females across 35 nations. The implication of associated disease-risk genes, involved in the susceptibility of COVID-19 such as the angiotensin-converting enzyme 2 (ACE2), has recently received considerable attention due to their role in severe injury of lung and mediated SARS-CoV-2 entry as a host receptor.
Objectives: Herein, we aimed to systematically review how two main genetic polymorphisms of ACE2 (rs2106809 and rs2074192) can affect the gender susceptibility to SARS-CoV-2 infection.
Methods: To conduct this systematic review, a literature search in PubMed, Google Scholar, ScienceDirect, and Nature was made for the period 2004 to 2020. We searched for the impact of ACE2 genetic polymorphisms (rs2106809 and rs2074192) on gender susceptibility.
Results: We noticed that there was a differential genotype distribution between males and females in various global populations whereas mutant variants were common in males compared to wild-type variants among females, which may reflect differences in gender susceptibility to infection with SARS-CoV-2. Females are less susceptible to coronavirus as compare to males because of the expression of ACE2 receptor. It has a double role in favour of COVID-19 and against COVID-19.
Conclusions: Male mortality is greater than female mortality, which might be attributed to the ACE2 deficiency in women. Epidemiological studies have shown that the differences in sex and age have different susceptibility to SARS-CoV-2 infection. |
| first_indexed | 2024-12-14T08:31:36Z |
| format | Article |
| id | doaj.art-7797a9a5574c4f329cb144d3736495ad |
| institution | Directory Open Access Journal |
| issn | 2706-9915 |
| language | English |
| last_indexed | 2024-12-14T08:31:36Z |
| publishDate | 2021-09-01 |
| publisher | College of Medicine, Al-Nahrain University |
| record_format | Article |
| series | Baghdad Journal of Biochemistry and Applied Biological Sciences |
| spelling | doaj.art-7797a9a5574c4f329cb144d3736495ad2022-12-21T23:09:31ZengCollege of Medicine, Al-Nahrain UniversityBaghdad Journal of Biochemistry and Applied Biological Sciences2706-99152021-09-0120316718010.47419/bjbabs.v2i03.53The impact of ACE2 genetic polymorphisms (rs2106809 and rs2074192) on gender susceptibility to COVID-19 infection and recovery: A systematic reviewAhmed A. Suleiman0https://orcid.org/0000-0001-7427-4483Tamadher A. Rafaa1https://orcid.org/0000-0003-1851-4555Ali M. Alrawi2Mustafa F. Dawood3Department of Biotechnology, College of Science, University of Anbar, Ramadi, IraqThe Presidency of the University of Anbar, Ramadi, IraqDepartment of Biotechnology, College of Science, University of Anbar, Ramadi, IraqCollege of Education for Pure Science, University of Anbar, Ramadi, IraqBackground: Epidemiological studies revealed there is a difference in susceptibility to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) because of differences in gender with age and males being more inflicted. There is a clear indication that deaths caused by coronavirus disease 2019 (COVID-19) in males appeared at a higher rate than females across 35 nations. The implication of associated disease-risk genes, involved in the susceptibility of COVID-19 such as the angiotensin-converting enzyme 2 (ACE2), has recently received considerable attention due to their role in severe injury of lung and mediated SARS-CoV-2 entry as a host receptor. Objectives: Herein, we aimed to systematically review how two main genetic polymorphisms of ACE2 (rs2106809 and rs2074192) can affect the gender susceptibility to SARS-CoV-2 infection. Methods: To conduct this systematic review, a literature search in PubMed, Google Scholar, ScienceDirect, and Nature was made for the period 2004 to 2020. We searched for the impact of ACE2 genetic polymorphisms (rs2106809 and rs2074192) on gender susceptibility. Results: We noticed that there was a differential genotype distribution between males and females in various global populations whereas mutant variants were common in males compared to wild-type variants among females, which may reflect differences in gender susceptibility to infection with SARS-CoV-2. Females are less susceptible to coronavirus as compare to males because of the expression of ACE2 receptor. It has a double role in favour of COVID-19 and against COVID-19. Conclusions: Male mortality is greater than female mortality, which might be attributed to the ACE2 deficiency in women. Epidemiological studies have shown that the differences in sex and age have different susceptibility to SARS-CoV-2 infection.https://bjbabs.org/index.php/bjbabs/article/view/53/43ace2covid-19gene polymorphismgendersars-cov-2 |
| spellingShingle | Ahmed A. Suleiman Tamadher A. Rafaa Ali M. Alrawi Mustafa F. Dawood The impact of ACE2 genetic polymorphisms (rs2106809 and rs2074192) on gender susceptibility to COVID-19 infection and recovery: A systematic review Baghdad Journal of Biochemistry and Applied Biological Sciences ace2 covid-19 gene polymorphism gender sars-cov-2 |
| title | The impact of ACE2 genetic polymorphisms (rs2106809 and rs2074192) on gender susceptibility to COVID-19 infection and recovery: A systematic review |
| title_full | The impact of ACE2 genetic polymorphisms (rs2106809 and rs2074192) on gender susceptibility to COVID-19 infection and recovery: A systematic review |
| title_fullStr | The impact of ACE2 genetic polymorphisms (rs2106809 and rs2074192) on gender susceptibility to COVID-19 infection and recovery: A systematic review |
| title_full_unstemmed | The impact of ACE2 genetic polymorphisms (rs2106809 and rs2074192) on gender susceptibility to COVID-19 infection and recovery: A systematic review |
| title_short | The impact of ACE2 genetic polymorphisms (rs2106809 and rs2074192) on gender susceptibility to COVID-19 infection and recovery: A systematic review |
| title_sort | impact of ace2 genetic polymorphisms rs2106809 and rs2074192 on gender susceptibility to covid 19 infection and recovery a systematic review |
| topic | ace2 covid-19 gene polymorphism gender sars-cov-2 |
| url | https://bjbabs.org/index.php/bjbabs/article/view/53/43 |
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