The Hexosamine Biosynthesis Pathway: Regulation and Function

The Hexosamine Biosynthesis Pathway: Regulation and Function

The hexosamine biosynthesis pathway (HBP) produces uridine diphosphate-<i>N</i>-acetyl glucosamine, UDP-GlcNAc, which is a key metabolite that is used for <i>N</i>- or <i>O</i>-linked glycosylation, a co- or post-translational modification, respectively, that modu...

Full description

Bibliographic Details
Main Authors:	Alysta Paneque, Harvey Fortus, Julia Zheng, Guy Werlen, Estela Jacinto
Format:	Article
Language:	English
Published:	MDPI AG 2023-04-01
Series:	Genes
Subjects:	hexosamine biosynthesis pathway GFAT1 GFAT2 Gfpt1 glycosylation metabolism
Online Access:	https://www.mdpi.com/2073-4425/14/4/933

Similar Items

Drosophila GFAT1 and GFAT2 enzymes encode obligate developmental functions
by: Po Chen, et al.
Published: (2020-10-01)

Characterization of <i>Gfat1</i> (<i>zeppelin</i>) and <i>Gfat2</i>, Essential Paralogous Genes Which Encode the Enzymes That Catalyze the Rate-Limiting Step in the Hexosamine Biosynthetic Pathway in <i>Drosophila melanogaster</i>
by: Shawn Cotsworth, et al.
Published: (2022-01-01)

GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway
by: Virginia Kroef, et al.
Published: (2022-03-01)

Current knowledge and potential intervention of hexosamine biosynthesis pathway in lung cancer
by: Yi Zou, et al.
Published: (2023-10-01)

The Nutrient-Sensing Hexosamine Biosynthetic Pathway as the Hub of Cancer Metabolic Rewiring
by: Ferdinando Chiaradonna, et al.
Published: (2018-06-01)

RELA∙8-Oxoguanine DNA Glycosylase1 Is an Epigenetic Regulatory Complex Coordinating the Hexosamine Biosynthetic Pathway in RSV Infection
by: Xiaofang Xu, et al.
Published: (2022-07-01)

Hexosamine biosynthesis and related pathways, protein N-glycosylation and O-GlcNAcylation: their interconnection and role in plants
by: Ya-Huei Chen, et al.
Published: (2024-03-01)

The dual role of the hexosamine biosynthetic pathway in cardiac physiology and pathophysiology
by: Megan Cairns, et al.
Published: (2022-10-01)

Detoxification of Hyperglycemia-induced Glucose Toxicity by the Hexosamine Biosynthetic Pathway
by: Andrew Jun Wang, et al.
Published: (2024-02-01)

Differential hexosamine biosynthetic pathway gene expression with type 2 diabetes
by: Megan Coomer, et al.
Published: (2014-01-01)

A study to assess serum and tissue levels of sialic acid and hexosamine in keloids
by: M Girija Menon, et al.
Published: (2015-01-01)

Contribution of the hexosamine biosynthetic pathway in the hyperglycemia-dependent and -independent breakdown of the retinal neurovascular unit
by: Yixin Wang, et al.
Published: (2023-07-01)

Glutamine deprivation triggers NAGK-dependent hexosamine salvage
by: Sydney Campbell, et al.
Published: (2021-11-01)

Repeated sleep deprivation decreases the flux into hexosamine biosynthetic pathway/O-GlcNAc cycling and aggravates Alzheimer’s disease neuropathology in adult zebrafish
by: Jiwon Park, et al.
Published: (2023-11-01)

A nexus of lipid and O-Glcnac metabolism in physiology and disease
by: Amber Lockridge, et al.
Published: (2022-08-01)

Interference of Arabidopsis N-Acetylglucosamine-1-P Uridylyltransferase Expression Impairs Protein N-Glycosylation and Induces ABA-Mediated Salt Sensitivity During Seed Germination and Early Seedling Development
by: Ya-Huei Chen, et al.
Published: (2022-06-01)

The Hexosamine Biosynthetic Pathway as a Therapeutic Target after Cartilage Trauma: Modification of Chondrocyte Survival and Metabolism by Glucosamine Derivatives and PUGNAc in an Ex Vivo Model
by: Jana Riegger, et al.
Published: (2021-07-01)

Targeting PGM3 as a Novel Therapeutic Strategy in <i>KRAS/LKB1</i> Co-Mutant Lung Cancer
by: Hyunmin Lee, et al.
Published: (2022-01-01)

Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression
by: Muhammad Tariq Saeed, et al.
Published: (2016-09-01)

Diabetic Embryopathy Susceptibility in Mice Is Associated with Differential Dependence on Glucosamine and Modulation of High Glucose-Induced Oxidative Stress
by: Jin Hyuk Jung, et al.
Published: (2021-07-01)

Single cell and bulk RNA expression analyses identify enhanced hexosamine biosynthetic pathway and O-GlcNAcylation in acute myeloid leukemia blasts and stem cells
by: Robert Schauner, et al.
Published: (2024-03-01)

Suppression of the HBP Function Increases Pancreatic Cancer Cell Sensitivity to a Pan-RAS Inhibitor
by: Francesca Ricciardiello, et al.
Published: (2021-02-01)

The IRE1α–XBP1s Arm of the Unfolded Protein Response Activates N-Glycosylation to Remodel the Subepithelial Basement Membrane in Paramyxovirus Infection
by: Yingxin Zhao, et al.
Published: (2022-08-01)

Mitochondrial Functions, Energy Metabolism and Protein Glycosylation are Interconnected Processes Mediating Resistance to Bortezomib in Multiple Myeloma Cells
by: Daniele Tibullo, et al.
Published: (2020-04-01)

Glycosylation and methylation in the biosynthesis of isoflavonoids in Pueraria lobata
by: Changfu Li, et al.
Published: (2023-12-01)

Dietary glucosamine overcomes the defects in αβ-T cell ontogeny caused by the loss of de novo hexosamine biosynthesis
by: Guy Werlen, et al.
Published: (2022-12-01)

Slt2 Is Required to Activate ER-Stress-Protective Mechanisms through TORC1 Inhibition and Hexosamine Pathway Activation
by: Isabel E. Sánchez-Adriá, et al.
Published: (2022-01-01)

Abnormal decrement on high-frequency repetitive nerve stimulation in congenital myasthenic syndrome with GFPT1 mutations and review of literature
by: Ran An, et al.
Published: (2022-09-01)

Genetic and biochemical strategies for regulation of L-ascorbic acid biosynthesis in plants through the L-galactose pathway
by: Juan C. Castro, et al.
Published: (2023-03-01)

Genomic reconstruction and features of glycosylation pathways in the apicomplexan Cryptosporidium parasites
by: Dongqiang Wang, et al.
Published: (2022-11-01)

Insulin Resistance Does Not Impair Mechanical Overload-Stimulated Glucose Uptake, but Does Alter the Metabolic Fate of Glucose in Mouse Muscle
by: Luke A. Weyrauch, et al.
Published: (2020-07-01)

Insight into the Molecular Mechanism of Diabetic Kidney Disease and the Role of Metformin in Its Pathogenesis
by: Marcin Kleibert, et al.
Published: (2023-08-01)

Serine Biosynthesis Pathway Supports MYC–miR-494–EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells
by: Emilia Białopiotrowicz, et al.
Published: (2020-03-01)

Protein <i>O</i>-GlcNAcylation in Metabolic Modulation of Skeletal Muscle: A Bright but Long Way to Go
by: Yang Liu, et al.
Published: (2022-09-01)

Nutlin-3a induces KRAS mutant/p53 wild type lung cancer specific methuosis-like cell death that is dependent on GFPT2
by: Dasom Kim, et al.
Published: (2023-12-01)

Cancer‐associated fibroblast expression of glutamine fructose‐6‐phosphate aminotransferase 2 (GFPT2) is a prognostic marker in gastric cancer
by: Shuo Yang, et al.
Published: (2023-09-01)

Heparan Sulfate Proteoglycans Biosynthesis and Post Synthesis Mechanisms Combine Few Enzymes and Few Core Proteins to Generate Extensive Structural and Functional Diversity
by: Thibault Annaval, et al.
Published: (2020-09-01)

Carrageenan biosynthesis in red algae: A review
by: Antonin Chevenier, et al.
Published: (2023-12-01)

Tools and tactics to define specificity of metabolic chemical reporters
by: Mana Mohan Mukherjee, et al.
Published: (2023-12-01)

Hyaluronic acid fuels pancreatic cancer cell growth
by: Peter K Kim, et al.
Published: (2021-12-01)