Cellular Release of Infectious Hepatitis C Virus Particles via Endosomal Pathways
Hepatitis C virus (HCV) is a positive-sense, single-stranded RNA virus that causes chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. The release of infectious HCV particles from infected hepatocytes is a crucial step in viral dissemination and disease progression. While the exact mech...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/12/2430 |
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| author | Lin Deng Muchamad Ridotu Solichin Dewa Nyoman Murti Adyaksa Maria Alethea Septianastiti Rhamadianti Aulia Fitri Gede Ngurah Rsi Suwardan Chieko Matsui Takayuki Abe Ikuo Shoji |
| author_facet | Lin Deng Muchamad Ridotu Solichin Dewa Nyoman Murti Adyaksa Maria Alethea Septianastiti Rhamadianti Aulia Fitri Gede Ngurah Rsi Suwardan Chieko Matsui Takayuki Abe Ikuo Shoji |
| author_sort | Lin Deng |
| collection | DOAJ |
| description | Hepatitis C virus (HCV) is a positive-sense, single-stranded RNA virus that causes chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. The release of infectious HCV particles from infected hepatocytes is a crucial step in viral dissemination and disease progression. While the exact mechanisms of HCV particle release remain poorly understood, emerging evidence suggests that HCV utilizes intracellular membrane trafficking and secretory pathways. These pathways include the Golgi secretory pathway and the endosomal trafficking pathways, such as the recycling endosome pathway and the endosomal sorting complex required for transport (ESCRT)-dependent multivesicular bodies (MVBs) pathway. This review provides an overview of recent advances in understanding the release of infectious HCV particles, with a particular focus on the involvement of the host cell factors that participate in HCV particle release. By summarizing the current knowledge in this area, this review aims to contribute to a better understanding of endosomal pathways involved in the extracellular release of HCV particles and the development of novel antiviral strategies. |
| first_indexed | 2024-03-08T20:17:14Z |
| format | Article |
| id | doaj.art-779b24b2ec9940b1888e157619e4f321 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-08T20:17:14Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-779b24b2ec9940b1888e157619e4f3212023-12-22T14:49:25ZengMDPI AGViruses1999-49152023-12-011512243010.3390/v15122430Cellular Release of Infectious Hepatitis C Virus Particles via Endosomal PathwaysLin Deng0Muchamad Ridotu Solichin1Dewa Nyoman Murti Adyaksa2Maria Alethea Septianastiti3Rhamadianti Aulia Fitri4Gede Ngurah Rsi Suwardan5Chieko Matsui6Takayuki Abe7Ikuo Shoji8Division of Infectious Disease Control, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe 650-0017, JapanDivision of Infectious Disease Control, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe 650-0017, JapanDivision of Infectious Disease Control, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe 650-0017, JapanDivision of Infectious Disease Control, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe 650-0017, JapanDivision of Infectious Disease Control, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe 650-0017, JapanDivision of Infectious Disease Control, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe 650-0017, JapanDivision of Infectious Disease Control, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe 650-0017, JapanDivision of Infectious Disease Control, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe 650-0017, JapanDivision of Infectious Disease Control, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe 650-0017, JapanHepatitis C virus (HCV) is a positive-sense, single-stranded RNA virus that causes chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. The release of infectious HCV particles from infected hepatocytes is a crucial step in viral dissemination and disease progression. While the exact mechanisms of HCV particle release remain poorly understood, emerging evidence suggests that HCV utilizes intracellular membrane trafficking and secretory pathways. These pathways include the Golgi secretory pathway and the endosomal trafficking pathways, such as the recycling endosome pathway and the endosomal sorting complex required for transport (ESCRT)-dependent multivesicular bodies (MVBs) pathway. This review provides an overview of recent advances in understanding the release of infectious HCV particles, with a particular focus on the involvement of the host cell factors that participate in HCV particle release. By summarizing the current knowledge in this area, this review aims to contribute to a better understanding of endosomal pathways involved in the extracellular release of HCV particles and the development of novel antiviral strategies.https://www.mdpi.com/1999-4915/15/12/2430hepatitis C virusreleaseGolgirecycling endosomemultivesicular bodiesendosomal sorting complex required for transport machinery |
| spellingShingle | Lin Deng Muchamad Ridotu Solichin Dewa Nyoman Murti Adyaksa Maria Alethea Septianastiti Rhamadianti Aulia Fitri Gede Ngurah Rsi Suwardan Chieko Matsui Takayuki Abe Ikuo Shoji Cellular Release of Infectious Hepatitis C Virus Particles via Endosomal Pathways Viruses hepatitis C virus release Golgi recycling endosome multivesicular bodies endosomal sorting complex required for transport machinery |
| title | Cellular Release of Infectious Hepatitis C Virus Particles via Endosomal Pathways |
| title_full | Cellular Release of Infectious Hepatitis C Virus Particles via Endosomal Pathways |
| title_fullStr | Cellular Release of Infectious Hepatitis C Virus Particles via Endosomal Pathways |
| title_full_unstemmed | Cellular Release of Infectious Hepatitis C Virus Particles via Endosomal Pathways |
| title_short | Cellular Release of Infectious Hepatitis C Virus Particles via Endosomal Pathways |
| title_sort | cellular release of infectious hepatitis c virus particles via endosomal pathways |
| topic | hepatitis C virus release Golgi recycling endosome multivesicular bodies endosomal sorting complex required for transport machinery |
| url | https://www.mdpi.com/1999-4915/15/12/2430 |
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