Insight into the fundamental trade-offs of diffusion MRI from polarization-sensitive optical coherence tomography in ex vivo human brain
In the first study comparing high angular resolution diffusion MRI (dMRI) in the human brain to axonal orientation measurements from polarization-sensitive optical coherence tomography (PSOCT), we compare the accuracy of orientation estimates from various dMRI sampling schemes and reconstruction met...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-07-01
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| Series: | NeuroImage |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811920301919 |
| _version_ | 1828956012788318208 |
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| author | Robert Jones Giorgia Grisot Jean Augustinack Caroline Magnain David A. Boas Bruce Fischl Hui Wang Anastasia Yendiki |
| author_facet | Robert Jones Giorgia Grisot Jean Augustinack Caroline Magnain David A. Boas Bruce Fischl Hui Wang Anastasia Yendiki |
| author_sort | Robert Jones |
| collection | DOAJ |
| description | In the first study comparing high angular resolution diffusion MRI (dMRI) in the human brain to axonal orientation measurements from polarization-sensitive optical coherence tomography (PSOCT), we compare the accuracy of orientation estimates from various dMRI sampling schemes and reconstruction methods. We find that, if the reconstruction approach is chosen carefully, single-shell dMRI data can yield the same accuracy as multi-shell data, and only moderately lower accuracy than a full Cartesian-grid sampling scheme. Our results suggest that current dMRI reconstruction approaches do not benefit substantially from ultra-high b-values or from very large numbers of diffusion-encoding directions. We also show that accuracy remains stable across dMRI voxel sizes of 1 mm or smaller but degrades at 2 mm, particularly in areas of complex white-matter architecture. We also show that, as the spatial resolution is reduced, axonal configurations in a dMRI voxel can no longer be modeled as a small set of distinct axon populations, violating an assumption that is sometimes made by dMRI reconstruction techniques. Our findings have implications for in vivo studies and illustrate the value of PSOCT as a source of ground-truth measurements of white-matter organization that does not suffer from the distortions typical of histological techniques. |
| first_indexed | 2024-12-14T08:03:25Z |
| format | Article |
| id | doaj.art-779e25f8ca124a50bd3cbe7523c0eb4a |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-14T08:03:25Z |
| publishDate | 2020-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-779e25f8ca124a50bd3cbe7523c0eb4a2022-12-21T23:10:17ZengElsevierNeuroImage1095-95722020-07-01214116704Insight into the fundamental trade-offs of diffusion MRI from polarization-sensitive optical coherence tomography in ex vivo human brainRobert Jones0Giorgia Grisot1Jean Augustinack2Caroline Magnain3David A. Boas4Bruce Fischl5Hui Wang6Anastasia Yendiki7Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital & Harvard Medical School, Charlestown, MA, USADeepHealth, Inc., Belmont, MA, USAAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital & Harvard Medical School, Charlestown, MA, USAAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital & Harvard Medical School, Charlestown, MA, USANeurophotonics Center, Department of Biomedical Engineering, Boston University, Boston, MA, USAAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital & Harvard Medical School, Charlestown, MA, USAAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital & Harvard Medical School, Charlestown, MA, USAAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital & Harvard Medical School, Charlestown, MA, USA; Corresponding author.In the first study comparing high angular resolution diffusion MRI (dMRI) in the human brain to axonal orientation measurements from polarization-sensitive optical coherence tomography (PSOCT), we compare the accuracy of orientation estimates from various dMRI sampling schemes and reconstruction methods. We find that, if the reconstruction approach is chosen carefully, single-shell dMRI data can yield the same accuracy as multi-shell data, and only moderately lower accuracy than a full Cartesian-grid sampling scheme. Our results suggest that current dMRI reconstruction approaches do not benefit substantially from ultra-high b-values or from very large numbers of diffusion-encoding directions. We also show that accuracy remains stable across dMRI voxel sizes of 1 mm or smaller but degrades at 2 mm, particularly in areas of complex white-matter architecture. We also show that, as the spatial resolution is reduced, axonal configurations in a dMRI voxel can no longer be modeled as a small set of distinct axon populations, violating an assumption that is sometimes made by dMRI reconstruction techniques. Our findings have implications for in vivo studies and illustrate the value of PSOCT as a source of ground-truth measurements of white-matter organization that does not suffer from the distortions typical of histological techniques.http://www.sciencedirect.com/science/article/pii/S1053811920301919 |
| spellingShingle | Robert Jones Giorgia Grisot Jean Augustinack Caroline Magnain David A. Boas Bruce Fischl Hui Wang Anastasia Yendiki Insight into the fundamental trade-offs of diffusion MRI from polarization-sensitive optical coherence tomography in ex vivo human brain NeuroImage |
| title | Insight into the fundamental trade-offs of diffusion MRI from polarization-sensitive optical coherence tomography in ex vivo human brain |
| title_full | Insight into the fundamental trade-offs of diffusion MRI from polarization-sensitive optical coherence tomography in ex vivo human brain |
| title_fullStr | Insight into the fundamental trade-offs of diffusion MRI from polarization-sensitive optical coherence tomography in ex vivo human brain |
| title_full_unstemmed | Insight into the fundamental trade-offs of diffusion MRI from polarization-sensitive optical coherence tomography in ex vivo human brain |
| title_short | Insight into the fundamental trade-offs of diffusion MRI from polarization-sensitive optical coherence tomography in ex vivo human brain |
| title_sort | insight into the fundamental trade offs of diffusion mri from polarization sensitive optical coherence tomography in ex vivo human brain |
| url | http://www.sciencedirect.com/science/article/pii/S1053811920301919 |
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