Cellular Reprogramming—A Model for Melanoma Cellular Plasticity
Cellular plasticity of cancer cells is often associated with phenotypic heterogeneity and drug resistance and thus remains a major challenge for the treatment of melanoma and other types of cancer. Melanoma cells have the capacity to switch their phenotype during tumor progression, from a proliferat...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-11-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/21/8274 |
| _version_ | 1797548814468382720 |
|---|---|
| author | Karol Granados Juliane Poelchen Daniel Novak Jochen Utikal |
| author_facet | Karol Granados Juliane Poelchen Daniel Novak Jochen Utikal |
| author_sort | Karol Granados |
| collection | DOAJ |
| description | Cellular plasticity of cancer cells is often associated with phenotypic heterogeneity and drug resistance and thus remains a major challenge for the treatment of melanoma and other types of cancer. Melanoma cells have the capacity to switch their phenotype during tumor progression, from a proliferative and differentiated phenotype to a more invasive and dedifferentiated phenotype. However, the molecular mechanisms driving this phenotype switch are not yet fully understood. Considering that cellular heterogeneity within the tumor contributes to the high plasticity typically observed in melanoma, it is crucial to generate suitable models to investigate this phenomenon in detail. Here, we discuss the use of complete and partial reprogramming into induced pluripotent cancer (iPC) cells as a tool to obtain new insights into melanoma cellular plasticity. We consider this a relevant topic due to the high plasticity of melanoma cells and its association with a strong resistance to standard anticancer treatments. |
| first_indexed | 2024-03-10T15:05:07Z |
| format | Article |
| id | doaj.art-77a04b1921eb4a359aa4e418fa85eebc |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:05:07Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-77a04b1921eb4a359aa4e418fa85eebc2023-11-20T19:50:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-012121827410.3390/ijms21218274Cellular Reprogramming—A Model for Melanoma Cellular PlasticityKarol Granados0Juliane Poelchen1Daniel Novak2Jochen Utikal3Skin Cancer Unit, German Cancer Research Center (DKFZ), D-69120 Heidelberg, GermanySkin Cancer Unit, German Cancer Research Center (DKFZ), D-69120 Heidelberg, GermanySkin Cancer Unit, German Cancer Research Center (DKFZ), D-69120 Heidelberg, GermanySkin Cancer Unit, German Cancer Research Center (DKFZ), D-69120 Heidelberg, GermanyCellular plasticity of cancer cells is often associated with phenotypic heterogeneity and drug resistance and thus remains a major challenge for the treatment of melanoma and other types of cancer. Melanoma cells have the capacity to switch their phenotype during tumor progression, from a proliferative and differentiated phenotype to a more invasive and dedifferentiated phenotype. However, the molecular mechanisms driving this phenotype switch are not yet fully understood. Considering that cellular heterogeneity within the tumor contributes to the high plasticity typically observed in melanoma, it is crucial to generate suitable models to investigate this phenomenon in detail. Here, we discuss the use of complete and partial reprogramming into induced pluripotent cancer (iPC) cells as a tool to obtain new insights into melanoma cellular plasticity. We consider this a relevant topic due to the high plasticity of melanoma cells and its association with a strong resistance to standard anticancer treatments.https://www.mdpi.com/1422-0067/21/21/8274melanomacellular plasticityheterogeneitypartial reprogrammingphenotype switch |
| spellingShingle | Karol Granados Juliane Poelchen Daniel Novak Jochen Utikal Cellular Reprogramming—A Model for Melanoma Cellular Plasticity International Journal of Molecular Sciences melanoma cellular plasticity heterogeneity partial reprogramming phenotype switch |
| title | Cellular Reprogramming—A Model for Melanoma Cellular Plasticity |
| title_full | Cellular Reprogramming—A Model for Melanoma Cellular Plasticity |
| title_fullStr | Cellular Reprogramming—A Model for Melanoma Cellular Plasticity |
| title_full_unstemmed | Cellular Reprogramming—A Model for Melanoma Cellular Plasticity |
| title_short | Cellular Reprogramming—A Model for Melanoma Cellular Plasticity |
| title_sort | cellular reprogramming a model for melanoma cellular plasticity |
| topic | melanoma cellular plasticity heterogeneity partial reprogramming phenotype switch |
| url | https://www.mdpi.com/1422-0067/21/21/8274 |
| work_keys_str_mv | AT karolgranados cellularreprogrammingamodelformelanomacellularplasticity AT julianepoelchen cellularreprogrammingamodelformelanomacellularplasticity AT danielnovak cellularreprogrammingamodelformelanomacellularplasticity AT jochenutikal cellularreprogrammingamodelformelanomacellularplasticity |