Estimation of Effectiveness of Local Reactive Oxygen Species for Stimulation of Regenerative Processes in Experimental Burn Wound
The aim of this work was the comparative estimation of the efficiency of different variants of local ozone therapy in experimental burn wound. We conducted the experiments on 45 white Wistar rats being randomized for three groups. Every rat got contact thermal trauma (III degree; 20 bsp) of dorsal b...
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MDPI AG
2022-07-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/12/15/7638 |
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| author | Andrew K. Martusevich Andrey A. Struchkov Vladimir V. Nazarov Alexandra S. Fedotova Mikhail Yu. Artamonov Sergey P. Peretyagin |
| author_facet | Andrew K. Martusevich Andrey A. Struchkov Vladimir V. Nazarov Alexandra S. Fedotova Mikhail Yu. Artamonov Sergey P. Peretyagin |
| author_sort | Andrew K. Martusevich |
| collection | DOAJ |
| description | The aim of this work was the comparative estimation of the efficiency of different variants of local ozone therapy in experimental burn wound. We conducted the experiments on 45 white Wistar rats being randomized for three groups. Every rat got contact thermal trauma (III degree; 20 bsp) of dorsal body surface on the area 20%. Rats of the first group received a Levomecol treatment of wound, animals of the second group were locally treated by ozonized oil, and the third group rats received a combination of ozone and oxygen gas mixture intracutaneously, and the wounds were treated with Levomecol locally. The character and particularities of post-traumatic regeneration were studied by histological investigation. Local treatment with reactive oxygen species at an early period after burning is revealed to lead to more pronounced manifestation of reparative processes in burn wounds (production of granulation tissue, epidermis regeneration) than when applying Levomecolointment, and that is accompanied by more pronounced initial manifestation of scab rejection. Applying reactive oxygen species in ointment compositions at these stages of treatment with the conjuncture of infected wounds does not contribute marked initiation of reparative processes and can even force the inflammation processes. |
| first_indexed | 2024-03-09T05:36:46Z |
| format | Article |
| id | doaj.art-77a05d05259f4084953e66d51fd67ce3 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-09T05:36:46Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-77a05d05259f4084953e66d51fd67ce32023-12-03T12:28:29ZengMDPI AGApplied Sciences2076-34172022-07-011215763810.3390/app12157638Estimation of Effectiveness of Local Reactive Oxygen Species for Stimulation of Regenerative Processes in Experimental Burn WoundAndrew K. Martusevich0Andrey A. Struchkov1Vladimir V. Nazarov2Alexandra S. Fedotova3Mikhail Yu. Artamonov4Sergey P. Peretyagin5Laboratory of Translational Free Radical Biomedicine, Sechenov University, 119991 Moscow, RussiaAssociation of Russian Ozone Therapeutists, 603107 Nizhny Novgorod, RussiaLaboratory of Translational Free Radical Biomedicine, Sechenov University, 119991 Moscow, RussiaLaboratory of Medical Biophysics, Privolzhsky Research Medical University, 603005 Nizhny Novgorod, RussiaLaboratory of Translational Free Radical Biomedicine, Sechenov University, 119991 Moscow, RussiaLaboratory of Translational Free Radical Biomedicine, Sechenov University, 119991 Moscow, RussiaThe aim of this work was the comparative estimation of the efficiency of different variants of local ozone therapy in experimental burn wound. We conducted the experiments on 45 white Wistar rats being randomized for three groups. Every rat got contact thermal trauma (III degree; 20 bsp) of dorsal body surface on the area 20%. Rats of the first group received a Levomecol treatment of wound, animals of the second group were locally treated by ozonized oil, and the third group rats received a combination of ozone and oxygen gas mixture intracutaneously, and the wounds were treated with Levomecol locally. The character and particularities of post-traumatic regeneration were studied by histological investigation. Local treatment with reactive oxygen species at an early period after burning is revealed to lead to more pronounced manifestation of reparative processes in burn wounds (production of granulation tissue, epidermis regeneration) than when applying Levomecolointment, and that is accompanied by more pronounced initial manifestation of scab rejection. Applying reactive oxygen species in ointment compositions at these stages of treatment with the conjuncture of infected wounds does not contribute marked initiation of reparative processes and can even force the inflammation processes.https://www.mdpi.com/2076-3417/12/15/7638reactive oxygen speciesozone therapyburn woundregenerationLevomecol |
| spellingShingle | Andrew K. Martusevich Andrey A. Struchkov Vladimir V. Nazarov Alexandra S. Fedotova Mikhail Yu. Artamonov Sergey P. Peretyagin Estimation of Effectiveness of Local Reactive Oxygen Species for Stimulation of Regenerative Processes in Experimental Burn Wound Applied Sciences reactive oxygen species ozone therapy burn wound regeneration Levomecol |
| title | Estimation of Effectiveness of Local Reactive Oxygen Species for Stimulation of Regenerative Processes in Experimental Burn Wound |
| title_full | Estimation of Effectiveness of Local Reactive Oxygen Species for Stimulation of Regenerative Processes in Experimental Burn Wound |
| title_fullStr | Estimation of Effectiveness of Local Reactive Oxygen Species for Stimulation of Regenerative Processes in Experimental Burn Wound |
| title_full_unstemmed | Estimation of Effectiveness of Local Reactive Oxygen Species for Stimulation of Regenerative Processes in Experimental Burn Wound |
| title_short | Estimation of Effectiveness of Local Reactive Oxygen Species for Stimulation of Regenerative Processes in Experimental Burn Wound |
| title_sort | estimation of effectiveness of local reactive oxygen species for stimulation of regenerative processes in experimental burn wound |
| topic | reactive oxygen species ozone therapy burn wound regeneration Levomecol |
| url | https://www.mdpi.com/2076-3417/12/15/7638 |
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