Increased membrane cholesterol in lymphocytes diverts T-cells toward an inflammatory response.

Cell signaling for T-cell growth, differentiation, and apoptosis is initiated in the cholesterol-rich microdomains of the plasma membrane known as lipid rafts. Herein, we investigated whether enrichment of membrane cholesterol in lipid rafts affects antigen-specific CD4 T-helper cell functions. Enri...

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Bibliographic Details
Main Authors: Jacqueline Surls, Cristina Nazarov-Stoica, Margaret Kehl, Cara Olsen, Sofia Casares, Teodor-D Brumeanu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3378591?pdf=render

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