RISC in Development; A Review on RNA Induced Silencing Complex and its Contribution to Cellular Differentiation
Messenger RNAs may be targeted by short 19-27 nt RNAs generally called Small none-coding RNAs (snRNAs), the role of miRNAs among other snRNAs has been more studied and is well known. Many researches show that all compartments of RISC, Proteins and miRNAs take part in this wide range of regulatory im...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2011-04-01
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| Series: | International Journal of Hematology-Oncology and Stem Cell Research |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/19544.pdf&manuscript_id=19544 |
| _version_ | 1797714974051663872 |
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| author | Amirali Davoudpour |
| author_facet | Amirali Davoudpour |
| author_sort | Amirali Davoudpour |
| collection | DOAJ |
| description | Messenger RNAs may be targeted by short 19-27 nt RNAs generally called Small none-coding RNAs (snRNAs), the role of miRNAs among other snRNAs has been more studied and is well known. Many researches show that all compartments of RISC, Proteins and miRNAs take part in this wide range of regulatory impacts. Ago protein homologs plus miRNAs and target mRNAs form a silencing complex in P-bodies which lead to either cleavage, conservation or surprisingly amplification of target mRNA or gene product. This article reviews conceptions which contribute directly or implicate this important post transcriptional mechanism’s function to differentiation or fate of pluripotent cells. |
| first_indexed | 2024-03-12T07:59:55Z |
| format | Article |
| id | doaj.art-77abef078a0046ba84450f6af7f1467c |
| institution | Directory Open Access Journal |
| issn | 2008-3009 2008-2207 |
| language | English |
| last_indexed | 2024-03-12T07:59:55Z |
| publishDate | 2011-04-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | International Journal of Hematology-Oncology and Stem Cell Research |
| spelling | doaj.art-77abef078a0046ba84450f6af7f1467c2023-09-02T19:56:49ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-30092008-22072011-04-0152918RISC in Development; A Review on RNA Induced Silencing Complex and its Contribution to Cellular DifferentiationAmirali DavoudpourMessenger RNAs may be targeted by short 19-27 nt RNAs generally called Small none-coding RNAs (snRNAs), the role of miRNAs among other snRNAs has been more studied and is well known. Many researches show that all compartments of RISC, Proteins and miRNAs take part in this wide range of regulatory impacts. Ago protein homologs plus miRNAs and target mRNAs form a silencing complex in P-bodies which lead to either cleavage, conservation or surprisingly amplification of target mRNA or gene product. This article reviews conceptions which contribute directly or implicate this important post transcriptional mechanism’s function to differentiation or fate of pluripotent cells.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/19544.pdf&manuscript_id=19544DevelopmentEmbryoRNAi |
| spellingShingle | Amirali Davoudpour RISC in Development; A Review on RNA Induced Silencing Complex and its Contribution to Cellular Differentiation International Journal of Hematology-Oncology and Stem Cell Research Development Embryo RNAi |
| title | RISC in Development; A Review on RNA Induced Silencing Complex and its Contribution to Cellular Differentiation |
| title_full | RISC in Development; A Review on RNA Induced Silencing Complex and its Contribution to Cellular Differentiation |
| title_fullStr | RISC in Development; A Review on RNA Induced Silencing Complex and its Contribution to Cellular Differentiation |
| title_full_unstemmed | RISC in Development; A Review on RNA Induced Silencing Complex and its Contribution to Cellular Differentiation |
| title_short | RISC in Development; A Review on RNA Induced Silencing Complex and its Contribution to Cellular Differentiation |
| title_sort | risc in development a review on rna induced silencing complex and its contribution to cellular differentiation |
| topic | Development Embryo RNAi |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/19544.pdf&manuscript_id=19544 |
| work_keys_str_mv | AT amiralidavoudpour riscindevelopmentareviewonrnainducedsilencingcomplexanditscontributiontocellulardifferentiation |