Distinct functions and prognostic values of RORs in gastric cancer
Retinoic acid receptor-related orphan receptors (RORs) are frequently abnormally expressed in several human malignancies, including gastric cancer (GC). RORs are involved in the development and progression of GC through Wnt signaling pathway receptors and other common receptors. However, the prognos...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2020-05-01
|
| Series: | Open Medicine |
| Subjects: | |
| Online Access: | http://www.degruyter.com/view/j/med.2020.15.issue-1/med-2020-0406/med-2020-0406.xml?format=INT |
| _version_ | 1819022153287204864 |
|---|---|
| author | Gu Feng Liu Yuming Liu Yuan Cheng Shujie Yang Jihong Kang Ming Duan Wendu Liu Yan |
| author_facet | Gu Feng Liu Yuming Liu Yuan Cheng Shujie Yang Jihong Kang Ming Duan Wendu Liu Yan |
| author_sort | Gu Feng |
| collection | DOAJ |
| description | Retinoic acid receptor-related orphan receptors (RORs) are frequently abnormally expressed in several human malignancies, including gastric cancer (GC). RORs are involved in the development and progression of GC through Wnt signaling pathway receptors and other common receptors. However, the prognostic roles of individual RORs in patients with GC remain elusive. We accessed the prognostic roles of three RORs (RORα, RORβ, and RORγ) through “The Kaplan–Meier plotter” (KM plotter) database in patients with GC. For all patients with GC who were followed for 20 years, the low mRNA expression of all three RORs showed a significant correlation with better outcomes. We further accessed the prognostic value of individual RORs in different clinical pathological features including Lauren classification, clinical stages, pathological grades, HER2 status, and different treatments methods. The RORs demonstrated critical prognostic roles in GC. Expressions of RORs were higher in GC tissues when compared with normal gastric tissues. Moreover, knockdown of RORs significantly inhibited cell proliferation and migration, suggesting an oncogenic role of RORs in human GC. These findings suggest potential roles of RORs as biomarkers for GC prognosis and as oncogenes in GC. |
| first_indexed | 2024-12-21T04:18:28Z |
| format | Article |
| id | doaj.art-77ac2210c0384e9e874852347fe89406 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-12-21T04:18:28Z |
| publishDate | 2020-05-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-77ac2210c0384e9e874852347fe894062022-12-21T19:16:15ZengDe GruyterOpen Medicine2391-54632020-05-0115142443410.1515/med-2020-0406med-2020-0406Distinct functions and prognostic values of RORs in gastric cancerGu Feng0Liu Yuming1Liu Yuan2Cheng Shujie3Yang Jihong4Kang Ming5Duan Wendu6Liu Yan7Department of Hepatobiliary, Hospital of HeBei University, Baoding, ChinaGeneral Hospital of Huabei Petroleum Administration Bureau, Renqiu, ChinaBeijing Youan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatobiliary, Hospital of HeBei University, Baoding, ChinaDepartment of Hepatobiliary, Hospital of HeBei University, Baoding, ChinaDepartment of Hepatobiliary, Hospital of HeBei University, Baoding, ChinaDepartment of Hepatobiliary, Hospital of HeBei University, Baoding, ChinaDepartment of Hepatobiliary, Hospital of HeBei University, Baoding, ChinaRetinoic acid receptor-related orphan receptors (RORs) are frequently abnormally expressed in several human malignancies, including gastric cancer (GC). RORs are involved in the development and progression of GC through Wnt signaling pathway receptors and other common receptors. However, the prognostic roles of individual RORs in patients with GC remain elusive. We accessed the prognostic roles of three RORs (RORα, RORβ, and RORγ) through “The Kaplan–Meier plotter” (KM plotter) database in patients with GC. For all patients with GC who were followed for 20 years, the low mRNA expression of all three RORs showed a significant correlation with better outcomes. We further accessed the prognostic value of individual RORs in different clinical pathological features including Lauren classification, clinical stages, pathological grades, HER2 status, and different treatments methods. The RORs demonstrated critical prognostic roles in GC. Expressions of RORs were higher in GC tissues when compared with normal gastric tissues. Moreover, knockdown of RORs significantly inhibited cell proliferation and migration, suggesting an oncogenic role of RORs in human GC. These findings suggest potential roles of RORs as biomarkers for GC prognosis and as oncogenes in GC.http://www.degruyter.com/view/j/med.2020.15.issue-1/med-2020-0406/med-2020-0406.xml?format=INTgastric cancerprognosisproliferationretinoic acid receptor-related orphan receptors |
| spellingShingle | Gu Feng Liu Yuming Liu Yuan Cheng Shujie Yang Jihong Kang Ming Duan Wendu Liu Yan Distinct functions and prognostic values of RORs in gastric cancer Open Medicine gastric cancer prognosis proliferation retinoic acid receptor-related orphan receptors |
| title | Distinct functions and prognostic values of RORs in gastric cancer |
| title_full | Distinct functions and prognostic values of RORs in gastric cancer |
| title_fullStr | Distinct functions and prognostic values of RORs in gastric cancer |
| title_full_unstemmed | Distinct functions and prognostic values of RORs in gastric cancer |
| title_short | Distinct functions and prognostic values of RORs in gastric cancer |
| title_sort | distinct functions and prognostic values of rors in gastric cancer |
| topic | gastric cancer prognosis proliferation retinoic acid receptor-related orphan receptors |
| url | http://www.degruyter.com/view/j/med.2020.15.issue-1/med-2020-0406/med-2020-0406.xml?format=INT |
| work_keys_str_mv | AT gufeng distinctfunctionsandprognosticvaluesofrorsingastriccancer AT liuyuming distinctfunctionsandprognosticvaluesofrorsingastriccancer AT liuyuan distinctfunctionsandprognosticvaluesofrorsingastriccancer AT chengshujie distinctfunctionsandprognosticvaluesofrorsingastriccancer AT yangjihong distinctfunctionsandprognosticvaluesofrorsingastriccancer AT kangming distinctfunctionsandprognosticvaluesofrorsingastriccancer AT duanwendu distinctfunctionsandprognosticvaluesofrorsingastriccancer AT liuyan distinctfunctionsandprognosticvaluesofrorsingastriccancer |