Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders.
Accumulating evidence suggests that dysregulation of the immune system is involved in the pathophysiology of autism spectrum disorders (ASD). The aim of the study was to explore immunological markers in peripheral plasma samples from non-medicated subjects with high-functioning ASD.A multiplex assay...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3103577?pdf=render |
| _version_ | 1811225196234801152 |
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| author | Katsuaki Suzuki Hideo Matsuzaki Keiko Iwata Yosuke Kameno Chie Shimmura Satomi Kawai Yujiro Yoshihara Tomoyasu Wakuda Kiyokazu Takebayashi Shu Takagai Kaori Matsumoto Kenji J Tsuchiya Yasuhide Iwata Kazuhiko Nakamura Masatsugu Tsujii Toshirou Sugiyama Norio Mori |
| author_facet | Katsuaki Suzuki Hideo Matsuzaki Keiko Iwata Yosuke Kameno Chie Shimmura Satomi Kawai Yujiro Yoshihara Tomoyasu Wakuda Kiyokazu Takebayashi Shu Takagai Kaori Matsumoto Kenji J Tsuchiya Yasuhide Iwata Kazuhiko Nakamura Masatsugu Tsujii Toshirou Sugiyama Norio Mori |
| author_sort | Katsuaki Suzuki |
| collection | DOAJ |
| description | Accumulating evidence suggests that dysregulation of the immune system is involved in the pathophysiology of autism spectrum disorders (ASD). The aim of the study was to explore immunological markers in peripheral plasma samples from non-medicated subjects with high-functioning ASD.A multiplex assay for cytokines and chemokines was applied to plasma samples from male subjects with high-functioning ASD (n = 28) and matched controls (n = 28). Among a total of 48 analytes examined, the plasma concentrations of IL-1β, IL-1RA, IL-5, IL-8, IL-12(p70), IL-13, IL-17 and GRO-α were significantly higher in subjects with ASD compared with the corresponding values of matched controls after correction for multiple comparisons.The results suggest that abnormal immune responses as assessed by multiplex analysis of cytokines may serve as one of the biological trait markers for ASD. |
| first_indexed | 2024-04-12T09:02:42Z |
| format | Article |
| id | doaj.art-77ad74ed5b514a84bbaa6fa68576e4ef |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T09:02:42Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-77ad74ed5b514a84bbaa6fa68576e4ef2022-12-22T03:39:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0165e2047010.1371/journal.pone.0020470Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders.Katsuaki SuzukiHideo MatsuzakiKeiko IwataYosuke KamenoChie ShimmuraSatomi KawaiYujiro YoshiharaTomoyasu WakudaKiyokazu TakebayashiShu TakagaiKaori MatsumotoKenji J TsuchiyaYasuhide IwataKazuhiko NakamuraMasatsugu TsujiiToshirou SugiyamaNorio MoriAccumulating evidence suggests that dysregulation of the immune system is involved in the pathophysiology of autism spectrum disorders (ASD). The aim of the study was to explore immunological markers in peripheral plasma samples from non-medicated subjects with high-functioning ASD.A multiplex assay for cytokines and chemokines was applied to plasma samples from male subjects with high-functioning ASD (n = 28) and matched controls (n = 28). Among a total of 48 analytes examined, the plasma concentrations of IL-1β, IL-1RA, IL-5, IL-8, IL-12(p70), IL-13, IL-17 and GRO-α were significantly higher in subjects with ASD compared with the corresponding values of matched controls after correction for multiple comparisons.The results suggest that abnormal immune responses as assessed by multiplex analysis of cytokines may serve as one of the biological trait markers for ASD.http://europepmc.org/articles/PMC3103577?pdf=render |
| spellingShingle | Katsuaki Suzuki Hideo Matsuzaki Keiko Iwata Yosuke Kameno Chie Shimmura Satomi Kawai Yujiro Yoshihara Tomoyasu Wakuda Kiyokazu Takebayashi Shu Takagai Kaori Matsumoto Kenji J Tsuchiya Yasuhide Iwata Kazuhiko Nakamura Masatsugu Tsujii Toshirou Sugiyama Norio Mori Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders. PLoS ONE |
| title | Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders. |
| title_full | Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders. |
| title_fullStr | Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders. |
| title_full_unstemmed | Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders. |
| title_short | Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders. |
| title_sort | plasma cytokine profiles in subjects with high functioning autism spectrum disorders |
| url | http://europepmc.org/articles/PMC3103577?pdf=render |
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