B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation

B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation

Germinal centers (GCs) are induced microanatomical structures wherein B cells undergo affinity maturation to improve the quality of the antibody response. Although GCs are crucial to appropriate humoral responses to infectious challenges and vaccines, many questions remain about the molecular signal...

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Bibliographic Details
Main Authors: Kenneth Green, Thomas R. Wittenborn, Cecilia Fahlquist-Hagert, Ewa Terczynska-Dyla, Nina van Campen, Lisbeth Jensen, Line Reinert, Rune Hartmann, Søren R. Paludan, Søren E. Degn
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Immunology
Subjects:
B cells
germinal centers
autoreactivity
autoimmunity
cGAS
STING
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.782558/full

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