OLR1, PON1 and MTHFR Gene Polymorphisms, Conventional Risk Factors and the Severity of Coronary Atherosclerosis in a Chinese Han Population
Aims: To explore the association between six single-nucleotide polymorphisms in OLR1, PON1, MTHFR gene and the angiographical characteristics of coronary atherosclerosis to determine if any of the conventional factors correlate with genetic polymorphisms in the advent of the disease. Methods: We exa...
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Cell Physiol Biochem Press GmbH & Co KG
2013-01-01
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| Series: | Cellular Physiology and Biochemistry |
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| Online Access: | http://www.karger.com/Article/FullText/343356 |
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| author | Yan Gu Zhe Liu Li Li Chang-Yan Guo Chun-Jian Li Lian-Sheng Wang Zhi-Jian Yang Wen-Zhu Ma En-Zhi Jia |
| author_facet | Yan Gu Zhe Liu Li Li Chang-Yan Guo Chun-Jian Li Lian-Sheng Wang Zhi-Jian Yang Wen-Zhu Ma En-Zhi Jia |
| author_sort | Yan Gu |
| collection | DOAJ |
| description | Aims: To explore the association between six single-nucleotide polymorphisms in OLR1, PON1, MTHFR gene and the angiographical characteristics of coronary atherosclerosis to determine if any of the conventional factors correlate with genetic polymorphisms in the advent of the disease. Methods: We examined rs1801131, rs1801133, rs3736232, rs3736234, rs854563 and rs662 by TaqMan® SNP Genotyping Assays in 1075 subjects that underwent angiography. The angiographical characteristics of coronary atherosclerosis were defined by the Gensini Score system. Results: The T allele of rs1801133 was associated with coronary atherosclerosis severity with the OR = 1.49, 95% CI = 1.04-2.14. In MTHFR gene, haplotype T-A was a susceptibility haplotype to coronary atherosclerosis (OR = 1.27, 95% CI = 1.06-1.51) whereas haplotype C-A had a protective effect (OR = 0.83, 95% CI = 0.70-0.99). In addition, several synergistic effects between rs1801133 and conventional risk factors such as diabetes and smoking were found. Conclusions: Collectively, the results demonstrate that the T allele of rs1801133 conferred an increased risk for coronary atherosclerosis. The MTHFR C-A haplotype was a protective haplotype, while T-A haplotype was a susceptibility haplotype. The presence of the T allele of rs1801133 increases the odds of coronary atherosclerosis severity when associated with conventional risk factors. |
| first_indexed | 2024-04-13T18:52:51Z |
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| id | doaj.art-77b1efc9fa754fd1a3a18f8036c2ce28 |
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| issn | 1015-8987 1421-9778 |
| language | English |
| last_indexed | 2024-04-13T18:52:51Z |
| publishDate | 2013-01-01 |
| publisher | Cell Physiol Biochem Press GmbH & Co KG |
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| series | Cellular Physiology and Biochemistry |
| spelling | doaj.art-77b1efc9fa754fd1a3a18f8036c2ce282022-12-22T02:34:22ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782013-01-0131114315210.1159/000343356343356OLR1, PON1 and MTHFR Gene Polymorphisms, Conventional Risk Factors and the Severity of Coronary Atherosclerosis in a Chinese Han PopulationYan GuZhe LiuLi LiChang-Yan GuoChun-Jian LiLian-Sheng WangZhi-Jian YangWen-Zhu MaEn-Zhi JiaAims: To explore the association between six single-nucleotide polymorphisms in OLR1, PON1, MTHFR gene and the angiographical characteristics of coronary atherosclerosis to determine if any of the conventional factors correlate with genetic polymorphisms in the advent of the disease. Methods: We examined rs1801131, rs1801133, rs3736232, rs3736234, rs854563 and rs662 by TaqMan® SNP Genotyping Assays in 1075 subjects that underwent angiography. The angiographical characteristics of coronary atherosclerosis were defined by the Gensini Score system. Results: The T allele of rs1801133 was associated with coronary atherosclerosis severity with the OR = 1.49, 95% CI = 1.04-2.14. In MTHFR gene, haplotype T-A was a susceptibility haplotype to coronary atherosclerosis (OR = 1.27, 95% CI = 1.06-1.51) whereas haplotype C-A had a protective effect (OR = 0.83, 95% CI = 0.70-0.99). In addition, several synergistic effects between rs1801133 and conventional risk factors such as diabetes and smoking were found. Conclusions: Collectively, the results demonstrate that the T allele of rs1801133 conferred an increased risk for coronary atherosclerosis. The MTHFR C-A haplotype was a protective haplotype, while T-A haplotype was a susceptibility haplotype. The presence of the T allele of rs1801133 increases the odds of coronary atherosclerosis severity when associated with conventional risk factors.http://www.karger.com/Article/FullText/343356Coronary atherosclerosisGensini scorePolymorphismsInteraction |
| spellingShingle | Yan Gu Zhe Liu Li Li Chang-Yan Guo Chun-Jian Li Lian-Sheng Wang Zhi-Jian Yang Wen-Zhu Ma En-Zhi Jia OLR1, PON1 and MTHFR Gene Polymorphisms, Conventional Risk Factors and the Severity of Coronary Atherosclerosis in a Chinese Han Population Cellular Physiology and Biochemistry Coronary atherosclerosis Gensini score Polymorphisms Interaction |
| title | OLR1, PON1 and MTHFR Gene Polymorphisms, Conventional Risk Factors and the Severity of Coronary Atherosclerosis in a Chinese Han Population |
| title_full | OLR1, PON1 and MTHFR Gene Polymorphisms, Conventional Risk Factors and the Severity of Coronary Atherosclerosis in a Chinese Han Population |
| title_fullStr | OLR1, PON1 and MTHFR Gene Polymorphisms, Conventional Risk Factors and the Severity of Coronary Atherosclerosis in a Chinese Han Population |
| title_full_unstemmed | OLR1, PON1 and MTHFR Gene Polymorphisms, Conventional Risk Factors and the Severity of Coronary Atherosclerosis in a Chinese Han Population |
| title_short | OLR1, PON1 and MTHFR Gene Polymorphisms, Conventional Risk Factors and the Severity of Coronary Atherosclerosis in a Chinese Han Population |
| title_sort | olr1 pon1 and mthfr gene polymorphisms conventional risk factors and the severity of coronary atherosclerosis in a chinese han population |
| topic | Coronary atherosclerosis Gensini score Polymorphisms Interaction |
| url | http://www.karger.com/Article/FullText/343356 |
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