Necrostatin-1 Ameliorates Peripheral Nerve Injury-Induced Neuropathic Pain by Inhibiting the RIP1/RIP3 Pathway

Necrostatin-1 Ameliorates Peripheral Nerve Injury-Induced Neuropathic Pain by Inhibiting the RIP1/RIP3 Pathway

Necrostatin-1 is an inhibitor of necroptosis, a form of programmed cell death that has been reported to be involved in various neurological diseases. Presently, the role of necroptosis in neuropathic pain induced by peripheral nerve injury is still unclear. This study was focused on investigating th...

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Bibliographic Details
Main Authors: Ying-Xia Liang, Nan-Nan Wang, Zhi-Yu Zhang, Zhao-Dong Juan, Can Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
necroptosis
necrostatin-1
neuropathic pain
inflammatory cytokines
hyperalgesia
peripheral nerve injury
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00211/full

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