Potent Bidirectional Cross-Talk Between Plasmacytoid Dendritic Cells and γδT Cells Through BTN3A, Type I/II IFNs and Immune Checkpoints

Potent Bidirectional Cross-Talk Between Plasmacytoid Dendritic Cells and γδT Cells Through BTN3A, Type I/II IFNs and Immune Checkpoints

Plasmacytoid DCs (pDCs) and γδT cells are both critical players in immunosurveillance against pathogens and cancer due to their ability to sense microbes and cell stress through recognition of pathogen-associated molecular patterns or altered metabolism [phosphoantigens (PAgs)]. Their unique feature...

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Bibliographic Details
Main Authors: Pauline Girard, Benedicte Ponsard, Julie Charles, Laurence Chaperot, Caroline Aspord
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
pDCs
γδ T cells
cross-talk
immune checkpoint
BTN3A
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00861/full

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