Non-hyalinizing trabecular thyroid adenoma: a novel thyroid tumor with diagnostic pitfalls of hyalinizing trabecular adenoma and medullary thyroid carcinoma
Abstract Background Only one thyroid follicular cell-derived tumor with a purely trabecular growth pattern has previously been described. This report aims to describe the histological, immunohistochemical, and molecular findings of our second case, propose a novel thyroid tumor, and discuss its diag...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Diagnostic Pathology |
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| Online Access: | https://doi.org/10.1186/s13000-023-01361-5 |
| _version_ | 1827917191045971968 |
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| author | Mitsuyoshi Hirokawa Michiko Matsuse Norisato Mitsutake Ayana Suzuki Miyoko Higuchi Toshitetsu Hayashi Hiroshi Kamma Akira Miyauchi Takashi Akamizu |
| author_facet | Mitsuyoshi Hirokawa Michiko Matsuse Norisato Mitsutake Ayana Suzuki Miyoko Higuchi Toshitetsu Hayashi Hiroshi Kamma Akira Miyauchi Takashi Akamizu |
| author_sort | Mitsuyoshi Hirokawa |
| collection | DOAJ |
| description | Abstract Background Only one thyroid follicular cell-derived tumor with a purely trabecular growth pattern has previously been described. This report aims to describe the histological, immunohistochemical, and molecular findings of our second case, propose a novel thyroid tumor, and discuss its diagnostic pitfalls. Case presentation A 68-year-old female presented with an encapsulated thyroid tumor composed of thin and long trabeculae. No papillary, follicular, solid, or insular patterns are observed. The tumor cells were elongated or fusiform and arranged perpendicular to the trabecular axis. No nuclear findings of papillary thyroid carcinoma and increased basement membrane material were found. Immunohistochemically, the tumor cells were positive for paired-box gene 8, thyroid transcription factor-1, and negative for thyroglobulin, calcitonin, and chromogranin A. Inter- and intra-trabecular accumulation of type IV collagen-positive materials was not demonstrated. None of PAX8/GLIS1 and PAX8/GLIS3 and mutations in BRAF, HRAS, KRAS, NRAS, TERT promoter, CTNNB1, PTEN, and RET were detected. Conclusions We report our case as a novel disease entity called non-hyalinizing trabecular thyroid adenoma, which has the diagnostic pitfalls of hyalinizing trabecular tumor and medullary thyroid carcinoma. |
| first_indexed | 2024-03-13T03:24:15Z |
| format | Article |
| id | doaj.art-77b593e326a24c91aec1f327f29ee211 |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-03-13T03:24:15Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-77b593e326a24c91aec1f327f29ee2112023-06-25T11:07:32ZengBMCDiagnostic Pathology1746-15962023-06-011811610.1186/s13000-023-01361-5Non-hyalinizing trabecular thyroid adenoma: a novel thyroid tumor with diagnostic pitfalls of hyalinizing trabecular adenoma and medullary thyroid carcinomaMitsuyoshi Hirokawa0Michiko Matsuse1Norisato Mitsutake2Ayana Suzuki3Miyoko Higuchi4Toshitetsu Hayashi5Hiroshi Kamma6Akira Miyauchi7Takashi Akamizu8Department of Diagnostic Pathology and Cytology, Kuma HospitalDepartment of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki UniversityDepartment of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki UniversityDepartment of Diagnostic Pathology and Cytology, Kuma HospitalDepartment of Diagnostic Pathology and Cytology, Kuma HospitalDepartment of Diagnostic Pathology and Cytology, Kuma HospitalNasu Insititute of Medical SciencesDepartment of Surgery, Kuma HospitalDepartment of Internal Medicine, Kuma HospitalAbstract Background Only one thyroid follicular cell-derived tumor with a purely trabecular growth pattern has previously been described. This report aims to describe the histological, immunohistochemical, and molecular findings of our second case, propose a novel thyroid tumor, and discuss its diagnostic pitfalls. Case presentation A 68-year-old female presented with an encapsulated thyroid tumor composed of thin and long trabeculae. No papillary, follicular, solid, or insular patterns are observed. The tumor cells were elongated or fusiform and arranged perpendicular to the trabecular axis. No nuclear findings of papillary thyroid carcinoma and increased basement membrane material were found. Immunohistochemically, the tumor cells were positive for paired-box gene 8, thyroid transcription factor-1, and negative for thyroglobulin, calcitonin, and chromogranin A. Inter- and intra-trabecular accumulation of type IV collagen-positive materials was not demonstrated. None of PAX8/GLIS1 and PAX8/GLIS3 and mutations in BRAF, HRAS, KRAS, NRAS, TERT promoter, CTNNB1, PTEN, and RET were detected. Conclusions We report our case as a novel disease entity called non-hyalinizing trabecular thyroid adenoma, which has the diagnostic pitfalls of hyalinizing trabecular tumor and medullary thyroid carcinoma.https://doi.org/10.1186/s13000-023-01361-5ThyroidHyalinizing trabecular tumorMedullary thyroid carcinomaPAX8/GLIS3 fusion gene |
| spellingShingle | Mitsuyoshi Hirokawa Michiko Matsuse Norisato Mitsutake Ayana Suzuki Miyoko Higuchi Toshitetsu Hayashi Hiroshi Kamma Akira Miyauchi Takashi Akamizu Non-hyalinizing trabecular thyroid adenoma: a novel thyroid tumor with diagnostic pitfalls of hyalinizing trabecular adenoma and medullary thyroid carcinoma Diagnostic Pathology Thyroid Hyalinizing trabecular tumor Medullary thyroid carcinoma PAX8/GLIS3 fusion gene |
| title | Non-hyalinizing trabecular thyroid adenoma: a novel thyroid tumor with diagnostic pitfalls of hyalinizing trabecular adenoma and medullary thyroid carcinoma |
| title_full | Non-hyalinizing trabecular thyroid adenoma: a novel thyroid tumor with diagnostic pitfalls of hyalinizing trabecular adenoma and medullary thyroid carcinoma |
| title_fullStr | Non-hyalinizing trabecular thyroid adenoma: a novel thyroid tumor with diagnostic pitfalls of hyalinizing trabecular adenoma and medullary thyroid carcinoma |
| title_full_unstemmed | Non-hyalinizing trabecular thyroid adenoma: a novel thyroid tumor with diagnostic pitfalls of hyalinizing trabecular adenoma and medullary thyroid carcinoma |
| title_short | Non-hyalinizing trabecular thyroid adenoma: a novel thyroid tumor with diagnostic pitfalls of hyalinizing trabecular adenoma and medullary thyroid carcinoma |
| title_sort | non hyalinizing trabecular thyroid adenoma a novel thyroid tumor with diagnostic pitfalls of hyalinizing trabecular adenoma and medullary thyroid carcinoma |
| topic | Thyroid Hyalinizing trabecular tumor Medullary thyroid carcinoma PAX8/GLIS3 fusion gene |
| url | https://doi.org/10.1186/s13000-023-01361-5 |
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