Estimating the risk of incident SARS-CoV-2 infection among healthcare workers in quarantine hospitals: the Egyptian example
Abstract In response to the COVID-19 epidemic, Egypt established a unique care model based on quarantine hospitals where only externally-referred confirmed COVID-19 patients were admitted, and healthcare workers resided continuously over 1- to 2-week working shifts. Using a mathematical model accoun...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-23428-x |
| _version_ | 1797983898047610880 |
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| author | Sofía Jijón Ahmad Al Shafie Essam Hassan EMAE-MESuRS working group on nosocomial SARS-CoV-2 modeling Laura Temime Kévin Jean Mohamed El-Kassas |
| author_facet | Sofía Jijón Ahmad Al Shafie Essam Hassan EMAE-MESuRS working group on nosocomial SARS-CoV-2 modeling Laura Temime Kévin Jean Mohamed El-Kassas |
| author_sort | Sofía Jijón |
| collection | DOAJ |
| description | Abstract In response to the COVID-19 epidemic, Egypt established a unique care model based on quarantine hospitals where only externally-referred confirmed COVID-19 patients were admitted, and healthcare workers resided continuously over 1- to 2-week working shifts. Using a mathematical model accounting for the false-negative rates of RT-PCR tests, we computed the incidence rate of SARS-CoV-2 infection among HCWs, while unveiling the proportion of infections remaining undiagnosed despite routine testing. We relied on longitudinal data, including results of routine RT-PCR tests, collected within three Egyptian quarantine hospitals. We estimated an incidence rate (per 100 person-day, PD) of 1.05 (95% CrI 0.58–1.65) at Hospital 1, 1.92 (95% CrI 0.93–3.28) at Hospital 2 and 7.62 (95% CrI 3.47–13.70) at Hospital 3. We found that the risk for an HCW to be infected during a working shift lay within the range of risk levels previously documented in standard healthcare settings for Hospitals 1–2, whereas it was > threefold higher for Hospital 3. This large variation suggests that HCWs from quarantine hospitals may face a high occupational risk of infection, but that, with sufficient infection control measures, this risk can be brought down to levels similar to those observed in standard healthcare settings. |
| first_indexed | 2024-04-11T06:54:38Z |
| format | Article |
| id | doaj.art-77b68366e4264e25ae42baee6f33dc35 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T06:54:38Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-77b68366e4264e25ae42baee6f33dc352022-12-22T04:39:04ZengNature PortfolioScientific Reports2045-23222022-11-011211810.1038/s41598-022-23428-xEstimating the risk of incident SARS-CoV-2 infection among healthcare workers in quarantine hospitals: the Egyptian exampleSofía Jijón0Ahmad Al Shafie1Essam Hassan2EMAE-MESuRS working group on nosocomial SARS-CoV-2 modelingLaura Temime3Kévin Jean4Mohamed El-Kassas5Laboratoire Modélisation, Epidémiologie et Surveillance des Risques Sanitaires (MESuRS), Conservatoire National des Arts et MétiersEndemic Medicine Department, Faculty of Medicine, Helwan UniversityTropical Medicine Department, Faculty of Medicine, Fayoum UniversityLaboratoire Modélisation, Epidémiologie et Surveillance des Risques Sanitaires (MESuRS), Conservatoire National des Arts et MétiersLaboratoire Modélisation, Epidémiologie et Surveillance des Risques Sanitaires (MESuRS), Conservatoire National des Arts et MétiersEndemic Medicine Department, Faculty of Medicine, Helwan UniversityAbstract In response to the COVID-19 epidemic, Egypt established a unique care model based on quarantine hospitals where only externally-referred confirmed COVID-19 patients were admitted, and healthcare workers resided continuously over 1- to 2-week working shifts. Using a mathematical model accounting for the false-negative rates of RT-PCR tests, we computed the incidence rate of SARS-CoV-2 infection among HCWs, while unveiling the proportion of infections remaining undiagnosed despite routine testing. We relied on longitudinal data, including results of routine RT-PCR tests, collected within three Egyptian quarantine hospitals. We estimated an incidence rate (per 100 person-day, PD) of 1.05 (95% CrI 0.58–1.65) at Hospital 1, 1.92 (95% CrI 0.93–3.28) at Hospital 2 and 7.62 (95% CrI 3.47–13.70) at Hospital 3. We found that the risk for an HCW to be infected during a working shift lay within the range of risk levels previously documented in standard healthcare settings for Hospitals 1–2, whereas it was > threefold higher for Hospital 3. This large variation suggests that HCWs from quarantine hospitals may face a high occupational risk of infection, but that, with sufficient infection control measures, this risk can be brought down to levels similar to those observed in standard healthcare settings.https://doi.org/10.1038/s41598-022-23428-x |
| spellingShingle | Sofía Jijón Ahmad Al Shafie Essam Hassan EMAE-MESuRS working group on nosocomial SARS-CoV-2 modeling Laura Temime Kévin Jean Mohamed El-Kassas Estimating the risk of incident SARS-CoV-2 infection among healthcare workers in quarantine hospitals: the Egyptian example Scientific Reports |
| title | Estimating the risk of incident SARS-CoV-2 infection among healthcare workers in quarantine hospitals: the Egyptian example |
| title_full | Estimating the risk of incident SARS-CoV-2 infection among healthcare workers in quarantine hospitals: the Egyptian example |
| title_fullStr | Estimating the risk of incident SARS-CoV-2 infection among healthcare workers in quarantine hospitals: the Egyptian example |
| title_full_unstemmed | Estimating the risk of incident SARS-CoV-2 infection among healthcare workers in quarantine hospitals: the Egyptian example |
| title_short | Estimating the risk of incident SARS-CoV-2 infection among healthcare workers in quarantine hospitals: the Egyptian example |
| title_sort | estimating the risk of incident sars cov 2 infection among healthcare workers in quarantine hospitals the egyptian example |
| url | https://doi.org/10.1038/s41598-022-23428-x |
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