Identification of adipose tissue-related predictors of the reduction in cardiovascular risk induced by metabolic surgery
Objectives We aimed to determine whether parameters associated with adipose tissue (adipocyte density and the circulating concentrations of markers of adipose tissue pathology) predict cardiovascular risk (CVR) modification after metabolic surgery (MS). Methods We performed a case–control study of p...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-05-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605211012569 |
| _version_ | 1818405043625263104 |
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| author | Alberto Melchor-López Juan Antonio Suárez-Cuenca Diana Zaineff Banderas-Lares Gustavo De la Peña-Sosa Moisés Salamanca-García Eduardo Vera-Gómez Alejandro Hernández-Patricio Juan Ariel Gutiérrez-Buendía Carlos Ramiro Zamora-Alemán Sofía Lizeth Alcaráz-Estrada Moisés Ortiz-Fernández Jesús Montoya-Ramírez Omar Felipe Gaytán-Fuentes Rebeca Pérez-Cabeza de Vaca Mónica Escamilla-Tilch Juan Antonio Pineda-Juárez Mario Antonio Téllez-González Paul Mondragón-Terán Martha Eunice Rodríguez-Arellano Alejandra Contreras-Ramos Silvia García Rolando Efraín Hernández-Muñoz |
| author_facet | Alberto Melchor-López Juan Antonio Suárez-Cuenca Diana Zaineff Banderas-Lares Gustavo De la Peña-Sosa Moisés Salamanca-García Eduardo Vera-Gómez Alejandro Hernández-Patricio Juan Ariel Gutiérrez-Buendía Carlos Ramiro Zamora-Alemán Sofía Lizeth Alcaráz-Estrada Moisés Ortiz-Fernández Jesús Montoya-Ramírez Omar Felipe Gaytán-Fuentes Rebeca Pérez-Cabeza de Vaca Mónica Escamilla-Tilch Juan Antonio Pineda-Juárez Mario Antonio Téllez-González Paul Mondragón-Terán Martha Eunice Rodríguez-Arellano Alejandra Contreras-Ramos Silvia García Rolando Efraín Hernández-Muñoz |
| author_sort | Alberto Melchor-López |
| collection | DOAJ |
| description | Objectives We aimed to determine whether parameters associated with adipose tissue (adipocyte density and the circulating concentrations of markers of adipose tissue pathology) predict cardiovascular risk (CVR) modification after metabolic surgery (MS). Methods We performed a case–control study of patients with morbid obesity who were candidates for MS. CVR was defined using flow-mediated dilation (FMD) and carotid intima media thickness (CIMT), which were measured during the 9 months following MS. Subgroups of CVR reduction were defined using the following cut-offs: CIMT 10% and/or a two-fold increase in FMD. Results We studied 40 patients with morbid obesity (mean age 44.5 years, 75% women, mean body mass index 46.4 kg/m 2 ) and high prevalences of the metabolically unhealthy obesity phenotype, hypertension, and diabetes mellitus. A significant reduction in CVR was associated with lower vascular endothelial growth factor-A concentration (6.20 vs. 1.59 pg/mL, respectively), low adipocyte density in visceral adipose tissue (100 vs. 80 cells/field), low infiltration with CD68+ cells (18 vs. 8 cells/field) and higher concentrations of lipid peroxidation markers and malondialdehyde (313.7 vs. 405.7 ng/mL). Conclusion The characteristics of adipose tissue and the circulating concentrations of markers of adipose pathology might represent useful predictors of the reduction in CVR following MS. Clinical trial registration number : NCT0356198 ( https://clinicaltrials.gov ) |
| first_indexed | 2024-12-14T08:49:46Z |
| format | Article |
| id | doaj.art-77b6ca9b58af4b8781560a55f43a5f14 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-14T08:49:46Z |
| publishDate | 2021-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-77b6ca9b58af4b8781560a55f43a5f142022-12-21T23:09:05ZengSAGE PublishingJournal of International Medical Research1473-23002021-05-014910.1177/03000605211012569Identification of adipose tissue-related predictors of the reduction in cardiovascular risk induced by metabolic surgeryAlberto Melchor-LópezJuan Antonio Suárez-CuencaDiana Zaineff Banderas-LaresGustavo De la Peña-SosaMoisés Salamanca-GarcíaEduardo Vera-GómezAlejandro Hernández-PatricioJuan Ariel Gutiérrez-BuendíaCarlos Ramiro Zamora-AlemánSofía Lizeth Alcaráz-EstradaMoisés Ortiz-FernándezJesús Montoya-RamírezOmar Felipe Gaytán-FuentesRebeca Pérez-Cabeza de VacaMónica Escamilla-TilchJuan Antonio Pineda-JuárezMario Antonio Téllez-GonzálezPaul Mondragón-TeránMartha Eunice Rodríguez-ArellanoAlejandra Contreras-RamosSilvia GarcíaRolando Efraín Hernández-MuñozObjectives We aimed to determine whether parameters associated with adipose tissue (adipocyte density and the circulating concentrations of markers of adipose tissue pathology) predict cardiovascular risk (CVR) modification after metabolic surgery (MS). Methods We performed a case–control study of patients with morbid obesity who were candidates for MS. CVR was defined using flow-mediated dilation (FMD) and carotid intima media thickness (CIMT), which were measured during the 9 months following MS. Subgroups of CVR reduction were defined using the following cut-offs: CIMT 10% and/or a two-fold increase in FMD. Results We studied 40 patients with morbid obesity (mean age 44.5 years, 75% women, mean body mass index 46.4 kg/m 2 ) and high prevalences of the metabolically unhealthy obesity phenotype, hypertension, and diabetes mellitus. A significant reduction in CVR was associated with lower vascular endothelial growth factor-A concentration (6.20 vs. 1.59 pg/mL, respectively), low adipocyte density in visceral adipose tissue (100 vs. 80 cells/field), low infiltration with CD68+ cells (18 vs. 8 cells/field) and higher concentrations of lipid peroxidation markers and malondialdehyde (313.7 vs. 405.7 ng/mL). Conclusion The characteristics of adipose tissue and the circulating concentrations of markers of adipose pathology might represent useful predictors of the reduction in CVR following MS. Clinical trial registration number : NCT0356198 ( https://clinicaltrials.gov )https://doi.org/10.1177/03000605211012569 |
| spellingShingle | Alberto Melchor-López Juan Antonio Suárez-Cuenca Diana Zaineff Banderas-Lares Gustavo De la Peña-Sosa Moisés Salamanca-García Eduardo Vera-Gómez Alejandro Hernández-Patricio Juan Ariel Gutiérrez-Buendía Carlos Ramiro Zamora-Alemán Sofía Lizeth Alcaráz-Estrada Moisés Ortiz-Fernández Jesús Montoya-Ramírez Omar Felipe Gaytán-Fuentes Rebeca Pérez-Cabeza de Vaca Mónica Escamilla-Tilch Juan Antonio Pineda-Juárez Mario Antonio Téllez-González Paul Mondragón-Terán Martha Eunice Rodríguez-Arellano Alejandra Contreras-Ramos Silvia García Rolando Efraín Hernández-Muñoz Identification of adipose tissue-related predictors of the reduction in cardiovascular risk induced by metabolic surgery Journal of International Medical Research |
| title | Identification of adipose tissue-related predictors of the reduction in cardiovascular risk induced by metabolic surgery |
| title_full | Identification of adipose tissue-related predictors of the reduction in cardiovascular risk induced by metabolic surgery |
| title_fullStr | Identification of adipose tissue-related predictors of the reduction in cardiovascular risk induced by metabolic surgery |
| title_full_unstemmed | Identification of adipose tissue-related predictors of the reduction in cardiovascular risk induced by metabolic surgery |
| title_short | Identification of adipose tissue-related predictors of the reduction in cardiovascular risk induced by metabolic surgery |
| title_sort | identification of adipose tissue related predictors of the reduction in cardiovascular risk induced by metabolic surgery |
| url | https://doi.org/10.1177/03000605211012569 |
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